Hairy root extract of Phyllanthus amarus induces apoptotic cell death in human breast cancer cells

Abhyankar, Gauri; Suprasanna, Penna; Pandey, Badri N.; Mishra, Kaushala Prasad; Rao, K. V.; Reddy, V. D.

doi:10.1016/j.ifset.2010.02.005

Cited by 39 publications

(25 citation statements)

References 37 publications

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“…The ability of P. amarus to exert antimetastatic activities is mostly associated to the presence of polyphenol compounds in its extracts (Lee et al, 2011). The methanolic extract of P. amarus hairy roots revealed potent antiproliferative activity in the MCF-7 cells through induction of apoptosis mediated by increased intracellular reactive oxygen species (ROS) in conjunction with decreased mitochondrial membrane potential (Abhyankar et al, 2010). The effects of aqueous extract of whole plant of P. amarus against Cr(VI)-induced oxidative toxicity in vitro in MDA-MB-435S human breast carcinoma cells revealed a distinct decline in Cr(VI)-induced cytotoxicity was noticed in MDA-MB-435S cells with an increase in extract dosage.…”

Section: Anticancer Activitymentioning

confidence: 99%

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

Patel

Tripathi²,

Sharma

et al. 2011

Journal of Ethnopharmacology

288

183

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Section: Anticancer Activitymentioning

confidence: 99%

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

Patel

Tripathi²,

Sharma

et al. 2011

Journal of Ethnopharmacology

288

183

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“…This suggests an appreciable anti‐proliferative effect of hairy root extract on MCF‐7 cells, by induction of apoptosis, thereby establishing potential anti‐cancer activity of the extract . Curcumin, as already mentioned has been demonstrated as an effective drug against various types of cancer .…”

Section: Natural Compounds and Breast Cancermentioning

confidence: 61%

Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

Luo²,

et al. 2014

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Natural products are chemical compounds or substances produced naturally by living organisms. With the development of modern technology, more and more plant extracts have been found to be useful to medical practice. Both micromolecules and macromolecules have been reported to have the ability to inhibit tumour progression, a novel weapon to fight cancer by targeting its 10 characteristic hallmarks. In this review, we focus on summarizing plant natural compounds and their derivatives with anti-tumour properties, into categories, according to their potential therapeutic strategies against different types of human cancer. Taken together, we present a well-grounded review of these properties, hoping to shed new light on discovery of novel anti-tumour therapeutic drugs from known plant natural sources.

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“…Mumbai (India) 69 Aqueous extract of Phyllanthus amarus inhibits chromium (VI)-induced toxicity in MDA-MB-435S cells Vellore (India) 70 Anti-metastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PLoS ONE 6, e20994.…”

Section: Fertility Effect: Fertility In Malementioning

confidence: 99%

“…Anti-cancer Activity: The methanolic extract of P. amarus hairy roots revealed potent antiproliferative activity in the MCF-7 cells through induction of apoptosis mediated by increased intracellular reactive oxygen species (ROS) in conjunction with decreased mitochondrial membrane potential 69 . The effects of aqueous extract of the whole plant of P. amarus against Cr (VI)-induced oxidative toxicity in-vitro in MDA-MB-435S human breast carcinoma cells revealed a distinct decline in Cr(VI)-induced cytotoxicity was noticed in MDA-MB-435S cells with an increase in extract dosage.…”

mentioning

confidence: 99%

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2018

IJPSR

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ABSTRACT:Phyllanthus amarus Schum and Thonn herb is in traditional medicine for more than 3000 years. It belongs to a family of Euphorbiaceae and commonly known by the name of carry me seed, stone breaker, gala of wind, etc. It is a branching annual herb of 30 -60 cm height widely spread throughout tropics and sub-tropics as a weed. Phyllanthus amarus is gaining momentum for its hepatoprotective, anti-carcinogenic, anti-bacterial, anti-viral, antiinflammatory and more activities as it contains different combinations of secondary metabolites, which render them medicinal properties. The major class of bioactive compounds like alkaloids, flavonoids, lignans, sterols, tannins, triterpenes and volatile oils has been isolated. Lignans like phyllanthin and hypophyllanthin, flavonoids like quercetin were isolated from the leaves of P. amarus. This review is an effort to represent the phytochemicals and their pharmacological properties which constantly addresses a challenge because of a large number of compounds present as a mixture in the extract with trace amounts.

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Hairy root extract of Phyllanthus amarus induces apoptotic cell death in human breast cancer cells

Cited by 39 publications

References 37 publications

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

Phyllanthus amarus: Ethnomedicinal uses, phytochemistry and pharmacology: A review

Plant natural products: from traditional compounds to new emerging drugs in cancer therapy

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