Hairy Roots of Salvia Species for Bioactive Substances Production

Plant cell culture as emerging technology for production of active cosmetic ingredients

“…Because plant cells are considered totipotent, they have the potential to express the full genetic machinery coded in the nucleus, and thus, they are able to produce the full spectrum of characteristic secondary metabolites, found in mother plants. This is very important advantage especially for the production of rare bioactive compounds, as resveratrol, paclitaxel or terpenoids, which are usually found in low concentrations in plants and their isolation and purification requires the processing of large amounts plant biomass [21][22][23][24][25]. Moreover, in vitro cultured plant cells are characterized with fast growth, and the ability to accumulate large amount of uniform biomass for a short period of time [19,20].…”

“…It should be noted, that active cosmetic ingredients, obtained by the plant cell culture technology are popularized among the customers under the name "plant stem cells". It is [23,34]. The most of the existed plant cell culture production platforms are in fact developed on the basis of the use of dedifferentiated plant cells rather than on the culturing of the true plant stem cells.…”

“…Moreover, in vitro cultured plant cells are characterized with fast growth, and the ability to accumulate large amount of uniform biomass for a short period of time [19,20]. This is very important advantage especially for the production of rare bioactive compounds, as resveratrol, paclitaxel or terpenoids, which are usually found in low concentrations in plants and their isolation and purification requires the processing of large amounts plant biomass [21][22][23][24][25]. Additionally, plant cell culture technology offers a reliable and powerful production platform for continuous supply of contamination-free, phytochemically uniform biomass from herbal, aromatic, medicinal, and even from rare and threatened plant species [26].…”

“…Both callus cultures and cell suspensions could consist of dedifferentiated or true stem cells. On the opposite, the hairy roots are organ cultures, obtained by genetic transformation of plant cells[23,34]. Some of the plant cell culture technology -derived active cosmetic ingredients, currently available on the market are reviewed inTable 1.…”

Abietane Diterpenoids from the Hairy Roots of Salvia corrugata

“…Abietane diterpenoids, also with rearranged skeletal types, have been described for the aerial parts and the roots of many Salvia species [ 2 ], mainly European and Asian species [ 2 , 3 ], while their presence is commonly described as limited to the roots of the New World species [ 4 , 5 ]. These compounds are also referred to be produced from hairy root cultures of some of these plants [ 4 , 6 , 7 , 8 ]. Abietane diterpenoids exhibit several interesting biological activities including antimicrobial, antifungal, anti-leishmanial, antiplasmodial, antiviral, antioxidant, antitumour, cytotoxic and anti-inflammatory activities [ 2 , 3 , 9 , 10 , 11 , 12 ].…”