Half-Life of Blood Carboxyhemoglobin after Short-Term and Long-Term Exposure to Carbon Monoxide

Carbon monoxide in biological systems: an experimental and clinical study

“…We also found the elimination to follow first order kinetics, after correction for basal CO concentrations. This is not in agreement with other publications (Shimazu et al, 2000;Wagner et al, 1975;Wazawa et al, 1996), where observed differences in elimination kinetics may be explained in large part by different concentration levels. When high concentrations of CO are present, the distribution to tissues may be more significant, resulting in a biphasic concentration decrease.…”

“…Also, the goal of the studies in the literature is generally to find the best means of elimination and therefore they have administered high oxygen concentrations. Results from such studies show half-lives between 5-190 minutes (Kreck et al, 2001;Sasaki, 1975;Shimazu et al, 2000;Wagner et al, 1975). In our study, under normal conditions, we found the elimination time to be 60 minutes.…”

“…Previous studies have focused on patients exposed to CO in high concentrations, including fire victims (Weaver, Howe, Hopkins, & Chan, 2000) or after inhaling CO (Kreck, Shade, Lamm, McKinney, & Hlastala, 2001;Sasaki, 1975;Shimazu et al, 2000;Wagner, Horvath, & Dahms, 1975;Wazawa, Yamamoto, Yamamoto, Matsumoto, & Fukui, 1996). These studies often had a high start dose of CO and they examined best means of elimination of CO.…”

“…The elimination pattern for CO has not been fully elucidated either. Some have claimed that CO follows first orders kinetics with one compartmental elimination (Kreck et al, 2001;Sasaki, 1975;Weaver et al, 2000), while others speculate that it has second or multi-compartmental elimination (Shimazu et al, 2000;Wagner et al, 1975); (Wazawa et al, 1996). In a population pharmacokinetic study investigating the elimination time for CO in smokers, the results showed twocompartmental kinetics with a half-life of 1.6 h for the first phase and 30.9 h for the second phase (Cronenberger, Mould, Roethig, & Sarkar, 2007).…”

Circulatory effects and kinetics following acute administration of carbon monoxide in a porcine model

“…Previous studies have described patients in whom carbon monoxide exposure was high (5-82%), in fire victims (Weaver et al, 2000) or from inhalation of carbon monoxide (Kreck et al, 2001;Sasaki, 1975;Shimazu et al, 2000;Wazawa et al, 1996;Wagner et al, 1975). The aim of such studies was to investigate which factors influence the elimination of carbon monoxide and to find the best ventilation for the elimination.…”