Half life of gastrointestinal glucagon-like immunoreactive materials.

Tanaka, Ryoichi; Matsuyama, Tatsuo; Shima, Kenji; Sawazaki, N; Tarui, Seiichiro; Kumahara, Yuichi

doi:10.1507/endocrj1954.26.59

Cited by 11 publications

(4 citation statements)

References 6 publications

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“…On the other hand, our present experiment showed that gut GI regulated plasma glucose level after pancreatectomy as realready ported (Sakurai et al, 1975;Tanaka et al, 1979). In contrast, Felig et al (1976) reported that there was no relation between plasma glucose level and gut GI.…”

Section: Discussioncontrasting

confidence: 44%

The effect of hypophysectomy and hypophysis-trans-plantation on the secretion of gut glucagon immunoreactivity and gut glucagon-like immunoreactivity in depancreatized dogs.

Yoshida

Kondo

1980

Endocrinol Japon

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SynopsisThe role of hypophysis in the regulation mechanism of the secretion of gut glucagon immunoreactivity (gut GI) that was measured using C-terminal specific glucagon antiserum after pancreatectomy, and gut glucagon-like immunoreactivity (gut GLI) that was obtained by subtracting GI from total glucagon-like immunoreactivity (total GLI) which was measured using non-specific glucagon antiserum, was investigated in depancreatized dogs.Plasma glucose, gut GI and gut GLI levels were found to increase in totally depancreatized dogs. The former two showed a significant decrease after hypophysectomy, and were reversed by the hypophysis-transplantation, while gut GLI was not affected either by hypophysectomy or hypophysis-transplantation. Intramuscular injections of human growth hormone (HGH) or adrenocorticotropic hormone-Z (ACTH-Z) to depancreatized-hypophysectomized dogs had no effect on plasma glucose level or gut GI.It is concluded that hypophysis may promote the secretion of gut GI after pancreatectomy, but not of gut GLI. Gut GI seems to regulate plasma glucose level after pancreatectomy.However, the precise regulation mechanism of gut GI by the hypophysial hormone after pancreatectomy is not clarified yet.

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Section: Discussioncontrasting

confidence: 44%

The effect of hypophysectomy and hypophysis-trans-plantation on the secretion of gut glucagon immunoreactivity and gut glucagon-like immunoreactivity in depancreatized dogs.

Yoshida

Kondo

1980

Endocrinol Japon

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“…Plasma concentrations of enteroglucagon were higher than those of GLP-2 in both diabetic groups. This difference in concentration of the two peptides may be due to differences in plasma elimination rates50 which also may explain the differences between plasma concentrations of GLP-1 and enteroglucagon observed in rats after intestinal resection 51. However, the present data indicate that plasma concentrations of the biologically active form of GLP-2 parallel intestinal growth in diabetic rats more closely than enteroglucagon.…”

Section: Discussionmentioning

confidence: 99%

Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre

Thulesen

Hartmann

Nielsen

et al. 1999

Gut

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Background/Aims-Dietary fibre influence growth and function of the upper gastrointestinal tract. This study investigates the importance of dietary fibre in intestinal growth in experimental diabetes, and correlates intestinal growth with plasma levels of the intestinotrophic factor, glucagon-like peptide 2 (GLP-2). Methods-Male Wistar rats were randomised to the following groups: two streptozotocin-diabetic and two control groups fed either a fibre-containing or a fibre-free diet for three weeks. Intestinal weight, length, and morphometric data (villus height, villus area, crypt depth) were measured. Blood samples were obtained after two weeks for measurement of GLP-2 and enteroglucagon (glicentin, oxyntomodulin). Results-The mean daily consumption of food in the two diabetic groups was 40% higher than in controls. In diabetic rats fed fibre, the increase in intestinal weight from day 0 to 20 was sixfold greater than that of the controls and small intestine weight per cm length was increased by 50%. In the diabetic rats fed a fibre-free diet, intestinal growth was 30% less than in diabetic rats fed fibre, and intestinal weight increased only threefold compared with controls. Morphometric data showed that the intestinal increase in diabetic rats fed fibre was due primarily to growth of the mucosal layer. Villus height and crypt depth increased 60% and 40% respectively, but by only 20% in fibre-free diabetic rats. The plasma levels of GLP-2 parallelled diabetic intestinal growth, whereas plasma levels of enteroglucagon increased regardless of the extent of intestinal growth. Conclusions-Intestinal growth in experimental diabetes is strongly influenced by the presence of dietary fibre. The eVect may be mediated by GLP-2. (Gut 1999;45:672-678)

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“…The time constants for the fast components of glucagon disappearance determined for man (Assan 1972;Alford et al 1976), dogs (Tanaka et al 1979) and swine (van Hoorn et al 1978) ranged from 0·14 to 0·39 min-1 • MeR were calculated on the assumption that the basal secretion of glucagon was not depressed by glucagon infusion. This assumption may be incorrect.…”

Section: Discussionmentioning

confidence: 99%

Rates of Removal of Exogenous and Endogenous Glucagon From the Plasma of Sheep in Vivo

Brockman¹

1980

Aust. Jnl. Of Bio. Sci.

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The removal of exogenous and endogenous glucagon from plasma was determined in vivo in sheep weighing 53±1 (mean±s.e.) kg. Porcine glucagon was infused intravenously for 90 min. The metabolic clearance rates (MCR) were determined from plateau immunoreactive glucagon (IRG) concentrations in plasma and infusion rates of glucagon. The mean clearance rate (±s.e.) was 16·7±1·6 litres per hour (n = 20). Upon termination of the infusion, the decrease in IRG concentrations in plasma was determined. Least-squares regression analysis of non-linear functions indicated the data fit a two-component exponential function. The time constant for the rapid component of the plasma IRG disappearance function was -0·32±0·04 min-1 (mean±s.e.). The time constant for the slow component was -0·022±0·008 min-'. The rate of removal of endogenous glucagon was estimated during the infusion of somatostatin when glucagon secretion was inhibited. The time constants (mean±s.e., n = 8) for the decrease in IRG during somatostatin infusion were -0·42±0·08 and -0·003±0·002 min-' for fast and slow components, respectively. The time constants for the rapid components of exogenous and endogenous glucagon were not significantly different. This suggests that endogenous and exogenous glucagon are similarly removed from plasma.

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Half life of gastrointestinal glucagon-like immunoreactive materials.

Cited by 11 publications

References 6 publications

The effect of hypophysectomy and hypophysis-trans-plantation on the secretion of gut glucagon immunoreactivity and gut glucagon-like immunoreactivity in depancreatized dogs.

The effect of hypophysectomy and hypophysis-trans-plantation on the secretion of gut glucagon immunoreactivity and gut glucagon-like immunoreactivity in depancreatized dogs.

Diabetic intestinal growth adaptation and glucagon-like peptide 2 in the rat: effects of dietary fibre

Rates of Removal of Exogenous and Endogenous Glucagon From the Plasma of Sheep in Vivo

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