Half-sandwich RuII[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: Preparation, structural characterization and in vitro cytotoxic activity

DNA binding properties, histidine interaction and cytotoxicity studies of water soluble ruthenium(ii) terpyridine complexes

“…45,60 Similar observations have been reported for the activity of the half-sandwich Ru(II)- [9]aneS3 complexes and for the half-sandwich organometallic compounds. 17,69,70 [Cl] (3) were synthesized as reported previously. 30 Microanalysis and UV-Vis and 1 H NMR spectroscopy were used to check the purity of the complexes and the spectra agreed well with the data already reported.…”

Studies on the interactions of a novel ruthenium(II) complex with G-quadruplex DNA

“…Ruthenium(II) complexes have long been investigated for their potential utility in chemotherapy and photodynamic therapy which is attributed to their structural similarity to cis-platinum [1][2][3][4][5][6][7][8]. In recent years a number of ruthenium complexes have been designed, and their antitumor activity, as well as their interaction with double strand DNA molecules has been studied extensively.…”

Mass spectrometry and UV‐VIS spectrophotometry of ruthenium(II) [RuClCp(mPTA)2](OSO2CF3)2 complex in solution

“…It was found that water-soluble species containing {RuClCp} interact more effectively with super-coiled DNA when mPTA acts as a ligand. [10][11][12] McNae et al 13 recently studied the physicochemical behavior of the cyclopentadienyl ligand in {Ru(PTA)} half-sandwich complexes and its pronounced effect on the biological activity was described. The chemical properties, stability and hydrolysis of such ruthenium complexes are insufficiently described in the literature, and the hydrolysis of species containing the {RuClCp(mPTA) 2 } 2þ entity has also not yet been completely …”