Halloysite nanotubes in biomedical applications: Recent approaches and future trends

Boraei, Seyyed Behnam Abdollahi; Eshghabadi, Fatemeh; Hosseinpour, Roghayeh; Zare, Yasser; Munir, Muhammad Tajammal; Rhee, Kyong Yop

doi:10.1016/j.clay.2024.107346

Cited by 12 publications

(1 citation statement)

References 158 publications

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“…HNTs are clay minerals with a chemical formula of Al 2 Si 2 O 5 (OH) 4 × nH 2 O, which keeps attracting notable attention for their use in several fields [18][19][20][21][22]. In particular, HNTs have been more often used for biomedical applications [23,24] since they show the intrinsic capability to cross cellular membranes, localizing themselves in the perinuclear region [25,26]. The different chemical composition of the tube surface (Si-O-Si groups on the external surface and Al-OH groups on the inner one) and the presence of an empty lumen are important features of achieving selective HNTs' chemical modification [27] for the delivery of active species, such as antioxidants [28], PNA [20,29], chemotherapeutic drugs [30,31] and so on [32].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Synthetic Pathways for Obtaining Fluorescent Nanomaterials Based on Halloysite and Carbon Dots for Potential Biological Sensing

Massaro,

Cinà,

Cavallaro

et al. 2024

IJMS

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Recently, fluorescent sensors have gained considerable attention due to their high sensitivity, low cost and noninvasiveness. Among the different materials that can be used for this purpose, carbon dots (CDs) represent valuable candidates for applications in sensing. These, indeed, are easily synthesized, show high quantum yield and are highly biocompatible. However, it was pointed out that the photoluminescence properties of these nanomaterials are strictly dependent on the synthetic and purification methods adopted. The presence of halloysite nanotubes (HNTs), a natural, low cost and biocompatible clay mineral, has been found to be efficient in obtaining small and highly monodispersed CDs without long and tedious purification techniques. Herein, we report the comparison of synthetic pathways for obtaining halloysite-N-doped CDs (HNTs-NCDs) that could be used in biological sensing. One was based on the synthesis of N-doped CDs by a bottom-up approach on HNTs’ surface by a MW pyrolysis process; the other one was based on the post-modification of pristine N-doped CDs with halloysite derivatives. The evaluation of the best synthetic route was performed by different physico-chemical techniques. It was found that the bottom-up approach led to the formation of N-doped CDs with different functional groups onto the HNTs’ surface. This evidence was also translated in the different fluorescence quantum yields and the existence of several functional groups in the obtained materials was investigated by potentiometric titrations. Furthermore, the ability of the synthesized nanomaterials as sensors for Fe3+ ions detection was assessed by spectroscopic measurements, and the cellular uptake was verified by confocal/fluorescence microscopies as well.

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Section: Introductionmentioning

confidence: 99%

Comparison of Synthetic Pathways for Obtaining Fluorescent Nanomaterials Based on Halloysite and Carbon Dots for Potential Biological Sensing

Massaro,

Cinà,

Cavallaro

et al. 2024

IJMS

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Curcumin and doxorubicin encapsulated in biocompatible clay‐based nanomaterial: A strategy to overcome multidrug resistance

Poma,

Massaro,

Rigogliuso

et al. 2024

Archiv der Pharmazie

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Multidrug resistance (MDR) due to the overexpression of the P‐glycoprotein (P‐gp) efflux pump remains a significant challenge in cancer therapy, also in breast cancer. Traditional pharmacological approaches have focused on using inhibitors to modulate P‐gp expression and function. Curcumin, a polyphenol derived from Curcuma longa L., is one of the most extensively studied natural compounds with the potential as an effective P‐gp inhibitor. Despite its promising attributes, the clinical application of P‐gp inhibitors is complicated by P‐gp's presence in healthy cells, such as those in the intestinal barrier and blood–brain barrier, which can lead to increased toxicity. To address these challenges, we developed a novel multifunctional nanomaterial by covalently bonding halloysite nanotubes (HNTs) with hectorite (Ht) and loading it with curcumin and doxorubicin. The efficacy of the co‐delivery of curcumin and doxorubicin by HNTs‐Ht nanomaterial was evaluated by cytotoxicity assays on MCF‐7R cells, both in two‐dimensional (2D) and in three‐dimensional (3D) models. The obtained data show that curcumin causes increased doxorubicin accumulation by acting as a substrate for P‐gp transport and as a stimulator of the adenosine triphosphate (ATP)‐dependent drug efflux transporter on a doxorubicin‐resistant breast cancer cell line. The results suggest that the HNTs‐Ht nanomaterial could provide a promising approach to improve chemotherapy effectiveness by overcoming MDR and enhancing treatment outcomes.

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Cataluminescence Sensor Based on Halloysite Nanotubes/MgO Nanocomposite for Rapid Detection of Ether

Liu,

Shi,

Zhang

et al. 2024

Luminescence

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MgO surface makes it easy to introduce a certain amount of oxygen vacancy and can enhance catalytic reaction activity. Besides, as a silicoaluminate mineral material, halloysite nanotube (HNT) has a unique tubular structure. In this paper, the HNTs@MgO composite was successfully synthesized based on natural clay material HNTs as a carrier, and the CTL sensor based on HNTs@MgO was successfully developed for the rapid determination of ether in air. The HNTs@MgO material was characterized by a series of means such as SEM, XPS, and XRD, which clearly confirmed that MgO successfully combined with HNTs. And the sensor showed good sensitivity and selectivity, with a good linear relationship between CTL intensity and ether concentration in the range of 0.5–190.0 mg/L (R2 = 0.9942), and the limit of detection (LOD) was 0.18 mg/L (S/N = 3). The RSD values of the results of 11 consecutive measurements by the same sensor and 7 days of consecutive measurements were 1.96% (n = 11) and 3.42% (n = 7), showing good repeatability and reproducibility. At last, the CTL sensor was used to detect air samples, the recoveries ranged from 91.6% to 109.6%. Thus, it was concluded that HNTs@MgO composite is a cost‐effective and promising material with potential application in atmospheric detection.

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Halloysite nanotubes in biomedical applications: Recent approaches and future trends

Cited by 12 publications

References 158 publications

Comparison of Synthetic Pathways for Obtaining Fluorescent Nanomaterials Based on Halloysite and Carbon Dots for Potential Biological Sensing

Comparison of Synthetic Pathways for Obtaining Fluorescent Nanomaterials Based on Halloysite and Carbon Dots for Potential Biological Sensing

Curcumin and doxorubicin encapsulated in biocompatible clay‐based nanomaterial: A strategy to overcome multidrug resistance

Cataluminescence Sensor Based on Halloysite Nanotubes/MgO Nanocomposite for Rapid Detection of Ether

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