Halo naevus or malignant melanoma: A case report

Langford, Matthew A.; Al-Ghazal, Sharif

doi:10.1016/j.jpra.2018.03.003

Cited by 2 publications

(1 citation statement)

References 7 publications

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“…[ 11 12 36 ] Studies also indicate the presence of halo nevus, hypopigmentation, or depigmentation that may occur in patients with melanoma. [ 37 ] KEGG pathway and Gene Ontology (GO) analysis revealed the top biological pathways targeted by the differentially expressed miRNAs, and the melanoma pathway with 11 targeted proteins is the most prominent one. This result indicates an indirect association of vitiligo with melanoma since many of the target proteins of differentially expressed miRNAs are functioning in the regulation of melanoma, cancer, and cancer-related pathways.…”

Section: Discussionmentioning

confidence: 99%

Differential Expression and in Silico Functional Analysis of Plasma MicroRNAs in the Pathogenesis of Non-segmental Vitiligo

Pektaş

Kara

Doğan

et al. 2022

Indian Journal of Dermatology

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Vitiligo is a disease characterized by acquired depigmentation, white macules, and patches on the skin due to the dysfunction of epidermal melanocytes. In this study, we attempt to profile the microRNA (miRNA) expression patterns and predict the potential targets, assessing the biological functions of differentially expressed miRNAs in the blood of generalized vitiligo patients. Peripheral blood samples were taken from all participants, and the expression levels of 89 identified miRNAs were analyzed with real-time quantitative polymerase chain reaction (PCR). The results indicated significant upregulation of six miRNAs and downregulation of 19 miRNAs in the plasma of vitiligo patients. The top three upregulated miRNAs were hsa-miR-451a, hsa-miR-25-3p, and hsa-miR-19a-3p, and the top three downregulated miRNAs were hsa-miR-146a-5p, hsa-miR-940, and hsa-miR-142-3p. Moreover, the miRNA expression profiles of patients with Type 3 and Type 4 phototypes were substantially different in such a way that the patients with Type 3 phototype would be more prone to the emergence of melanoma and cancer. While significant variations in the expression patterns of miRNAs in male and female vitiligo patients were demonstrated, miR-let-7i-5p, miR-19a-3p, miR-25-3p, and miR-451a were commonly upregulated, and miR-142-3p and miR-146a-5p were commonly repressed in both sexes. This study may shed light on the roles of differentially expressed miRNAs in vitiligo patients by examining the miRNA expression patterns and the combined effects of miRNA and their predicted targets.

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