Halo nevus, rather than vitiligo, is a typical dermatologic finding of Turner's syndrome: Clinical, genetic, and immunogenetic study in 72 patients

Autoimmune stigmata in Turner syndrome: When lacks an X chromosome

“…The actual frequency of vitiligo in TS is not significantly increased; Brazzelli et al described the presence of vitiligo only in 2.7% of TS patients [27].…”

“…More recently another dermatological abnormality, halo nevus, whose pathogenesis is supposed to be autoimmune, has been reported to be significantly more frequent in TS than in general population [27].…”

“…This is in keeping with the observation that Turner patients show a proneness to develop a wide array of immune-mediated disorders which are absolutely greater than the expected in general population. Indeed, the associations with the disease-specific susceptible HLA alleles are fully respected also in Turner's people: those HLA-B14 positive frequently carry the 21-OH mutation [25], those HLA-DRB1 * 0301 positive, when infected by Helicobacter pylori, evolve towards autoimmune thyroiditis [26], those carrying HLA-Cw6 allele are likely to develop halo nevi and, rarely, vitiligo [27], those who inherited the HLA-DR7,DQ2 and HLA-DR7,DQ9 haplotypes are frequently positive for organ-specific autoantibodies with paternal imprinting [14].…”

Lymphatic, tooth and skin manifestations in Turner syndrome

“…There are an increased number of melanocytic nevi in many individuals with Turner syndrome, mostly acquired in late childhood. Large or dysplastic nevi are uncommon [9], but a propensity for halo nevi has been reported [10]. Growth hormone treatment has been reported to increase the growth of nevi in children with Turner syndrome Fig.…”

Autoimmune diseases in Turner syndrome

“…It has been known that females with TS have an increased prevalence of autoantibodies and are at increased risk of developing autoimmune diseases such as: Hashimoto thyroiditis, pernicious anemia, Addison disease, celiac disease, inflammatory bowel disease, diabetes, autoimmune hepatitis, autoimmune colitis, thrombocytopenia, and juvenile rheumatoid arthritis [1][2][3][4][5][6][7][8][9].…”