Halogen-bond-assisted radical remote difunctionalization of bicyclo[1.1.1]butane skeletons

Abstract

Transition-metal-free radical remote difunctionalization of bicyclo[1.1.1]butane skeleton in both two- and three-component fashions is presented. The reactions proceed via halogen-bond-assisted polyfluoroalkyl radical addition to the newly designed 1-vinylbicyclo[1.1.1]pentanes, followed by...