Halogenated and organophosphorus flame retardants in European aquaculture samples

Aznar-Alemany, Òscar; Aminot, Yann; Vilà-Cano, Judit; Köck-Schulmeyer, Marianne; Readman, James W.; Marques, António; Godinho, Lia; Botteon, Elena; Ferrari, Federico; Boti, Vasiliki; Albanis, Triantafyllos A.; Eljarrat, Ethel; Barceló, Damià

doi:10.1016/j.scitotenv.2017.08.199

Cited by 91 publications

(20 citation statements)

References 52 publications

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“…TCEP (<1–3 μg/kg ww, not lipid) and TPP (2 μg/kg ww) were reported in Mytius galloprovincialis samples collected from Maizuru Bay, Japan, at tissue levels similar to those reported in this study . More recently, multiple organophosphorus flame retardants, including TCEP, were detected in marine mussels from Albania, Greece, Italy, Norway, Portugal, Spain, and the United Kingdom . Detected target analyte classes and concentrations in the present study were generally similar to these previous efforts.…”

Section: Resultssupporting

confidence: 89%

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Burket

Sapozhnikova

Zheng

et al. 2018

J. Agric. Food Chem.

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Aquaculture, which is growing 3-5 times faster than terrestrial agriculture, will play an important role to meet future global food production needs. However, over 80% of global sewage production is returned to the environment untreated or poorly treated. In developing nations, these nontraditional waters of diverse quality are being recycled for aquaculture, yet chemical residues are differentially studied. Here, we examined pharmaceuticals, pesticides, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), polycyclic aromatic hydrocarbons (PAHs), and flame retardants in marine bivalves using isotope dilution liquid chromatography-tandem mass spectrometry (LC-MS/MS) and low-pressure gas chromatography-tandem mass spectrometry (LP GC-MS/MS). Green-lipped mussels from the field and oysters from aquaculture net pens, which are harvested as food products, were collected adjacent to point source municipal wastewater and landfill leachate effluent discharges, respectively, in Hong Kong, the fourth most densely populated country in the world. Multiple classes of pharmaceutical, pesticides, PAHs, and phosphorus-based flame retardants were detected at low μg/kg levels. Acceptable servings per week indicated minimal risk for a number of chemicals; however, such calculations could not be performed for other contaminants of emerging concern. Future efforts are needed to better understand contaminant influences on marine bivalve populations and aquaculture product safety, particularly in rapidly urbanizing regions of developing countries with limited wastewater infrastructure.

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Section: Resultssupporting

confidence: 89%

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Burket

Sapozhnikova

Zheng

et al. 2018

J. Agric. Food Chem.

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“…Due to the prohibition and regulation of some brominated flame retardants (BFRs), the usage of organophosphate flame retardants (OPFRs) as alternatives and replacement flame retardants has increased significantly. − The worldwide consumption of OPFRs increased from 500 000 tons in 2011 to 680 000 tons in 2015, , which has resulted in the release of OPFRs into the environment and their detection in air, sediments, and water. ,− Chlorinated OPFRs are very persistent and more resistant to biodegradation than nonchlorinated OPFRs, which were not decomposed during wastewater treatment . Due to their high octanol–water partition coefficients, many OPFRs easily accumulate in sediments .…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)

Yan

Wang

Yang

et al. 2020

Environ. Sci. Technol.

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To compare the toxicities of a chlorinated and a nonchlorinated organophosphorus flame retardant (OPFR) in this study, adult calms (Corbicula fluminea) were exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tributyl phosphate (TNBP) at 20, 200, and 2000 μg/L for 30 days. Toxicity screening using transcriptomics indicated that the apoptosis pathway was significantly affected in the groups exposed to 2000 μg/L TDCIPP and TNBP (p ≤ 0.05), and this finding was further confirmed by the protein interaction network. The terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay suggested that TDCIPP and TNBP can cause apoptosis. The significant (p ≤ 0.05) increases in the activities of caspases 3 and 8 obtained with all treatments and in that of caspase 9 obtained with 2000 μg/L exposure treatments indicated the presence of mitochondria-dependent and mitochondria-independent apoptosis. Interestingly, a noticeable dose-dependent increase in DNA damage was observed in all treatments, resulting in apoptosis. Therefore, our results demonstrate that TDCIPP and TNBP induce DNA damage and apoptosis in C. fluminea, which indicates that these chemicals pose an ecological risk to benthic organisms. Moreover, through a similar mechanism of action in apoptosis, TDCIPP induced more serious toxicity than TNBP, which indicated that chlorination or differences in structure-specific metabolism could be key factors influencing toxicity.

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“…The occurrence of OPFRs in natural environments was first reported in the late 1970s (Saeger et al, 1979;Sheldon and Hites, 1978). Since then OPFRs have been detected in numerous environmental samples such as in air, wastewater effluent, household dust, sediment, and biota (Brandsma et al, 2015;Giulivo et al, 2017;Kademoglou et al, 2017;Kim et al, 2017;Aznar-Alemany et al, 2018;Herrero et al, 2018). However, their occurrence in the marine environment is not widely reported.…”

Section: Introductionmentioning

confidence: 99%

First determination of high levels of organophosphorus flame retardants and plasticizers in dolphins from Southern European waters

Sala

Giménez

Stephanis

et al. 2019

Environmental Research

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This study evaluates for the first time organophosphorus flame retardant (OPFR) occurrence in the Alboran Sea delphinids (Spain). OPFRs were detected in all the individuals with concentration levels up to 24.7 µg/g lw. Twelve out of sixteen tested analytes were detected, being TBOEP which presented the highest detection frequency, and IDPP which presented the highest levels of concentration. OPFR distribution in different tissues (blubber, brain, kidney, muscle and liver) was evaluated. The pattern distribution showed the highest contribution for blubber (mean value of 68%) and the lowest contribution for liver (mean value of 2%). Seven OPFRs were detected in brain samples showing their capacity to surpass the blood-brain barrier and reach the brain. Moreover, high affinity for the brain tissue was observed. This is extremely important due to the neurotoxic effects of several compounds such as TCEP and TNBP. OPFR levels were compared with previously published PBDE concentrations, and no significant differences were observed. Taking into account the lower use and lower bioaccumulation and biomagnification capacities of OPFRs, this could indicate an additional OPFR source of pollution in addition to their use as FRs.

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Halogenated and organophosphorus flame retardants in European aquaculture samples

Cited by 91 publications

References 52 publications

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

At the Intersection of Urbanization, Water, and Food Security: Determination of Select Contaminants of Emerging Concern in Mussels and Oysters from Hong Kong

Comparison of the Toxicity Effects of Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) with Tributyl Phosphate (TNBP) Reveals the Mechanism of the Apoptosis Pathway in Asian Freshwater Clams (Corbicula fluminea)

First determination of high levels of organophosphorus flame retardants and plasticizers in dolphins from Southern European waters

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