Halogenated Natural Products in Dolphins: Brain–Blubber Distribution and Comparison with Halogenated Flame Retardants

Barón, Enrique; Hauler, Carolin; Gallistl, Christoph; Giménez, Joan; Gauffier, Pauline; Castillo, Juan José; Fernández-Maldonado, Carolina; Stephanis, Renaud de; Vetter, Walter; Eljarrat, Ethel; Barceló, Damià

doi:10.1021/acs.est.5b02736

Cited by 37 publications

(43 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The lipid content of the brain of mice was 7.00%, much higher than that of liver (1.91%) and muscle tissues (0.59%), in the present study, the lowest concentrations of PBDEs were found in the brains of mice, ducks and chickens. Previous studies suggested that the BBB could be partly responsible for reduced PBDE accumulation in the brain relative to in other tissues (Baron et al, 2015;Voorspoels et al, 2006;Yang et al, 2011). Our results on several vertebrates support this proposal.…”

Section: Pbde Levels In the Brain Compared With Those In Other Tissuessupporting

confidence: 88%

“…The production of deca-BDEs has ceased in some European countries and in the USA, but they are still used in some developing countries, including China and South Africa (Abafe and Martincigh, 2015;Wan et al, 2013). Despite a declining trend in the levels of PBDEs observed in certain regions, this group of persistent pollutants is still detectable in various environmental media and biotic samples (Baron et al, 2015;Hassan et al, 2013;Yu et al, 2016;Zheng et al, 2015). It has been demonstrated that PBDEs adversely affect the developing brain, resulting in neurodevelopmental disorders (Costa et al, 2014(Costa et al, , 2016Kodavanti et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…However, there is evidence that the BBB dose not completely restrict the entry of lipophilic pollutants, which may enter the brain via lipidmediated free diffusion or carrier/receptor-mediated transport (Baron et al, 2015;Pardridge, 2012). PBDEs have been detected in brain tissues from several wildlife species, including fish (Barni et al, 2014;Nilsen et al, 2014), frogs (Li et al, 2014;Liu et al, 2011), river otters (Basu et al, 2007), birds (Voorspoels et al, 2006), polar bears (Gebbink et al, 2008), and dolphins (Baron et al, 2015). Generally, PBDE concentrations in the brain were lower than in other tissues, consistent with protection by the BBB against PBDE accumulation in the brain.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Zhao

Qin

et al. 2016

Environmental Pollution

View full text Add to dashboard Cite

a b s t r a c tThis study aimed to investigate the accumulation of polybrominated diphenyl ethers (PBDEs) in the brain compared with that in other tissues among different vertebrates. We collected mice, chickens, ducks, frogs, and fish from an e-waste recycling region in Taizhou, China, and measured PBDE concentrations in brain, liver and muscle tissues. The levels of PBDE in the tissues of mice, chickens, ducks, frogs and fish ranged 0.45e206, 0.06e18.8, 1.83e112, 2.75e108, and 0.02e32.0 ng/g wet weight, respectively. Preferential distribution in the liver and muscle relative to the brain was observed for PBDEs in mice, chickens, ducks and frogs. However, a high retention in the brain compared to the liver and muscle was observed in fish. Comparison of the brain/liver concentration (B/L) ratios revealed differences in PBDEs accumulation in the brain among these vertebrates. PBDEs accumulation in the brain was greatest in fish, followed by frogs, while the lowest accumulation occurred in the brains of mammals and birds. The findings apparently coincided with the evolution of the blood-brain barrier (BBB) across vertebrates, i.e. the BBB of fish might be less efficient than those of mammals, birds and amphibian. Low brominated congeners (such as BDE-28, BDE-47 and BDE-99) were predominant in the brains of investigated vertebrates, whereas BDE-209 was most abundant in liver and muscle tissues of mice, chickens and ducks. Significant differences in B/L ratios among PBDE congeners were found in both mice and chickens (p < 0.05). Particularly in mice, the B/L ratios of PBDE congeners presented a declining trend with increased bromine number. Our findings suggested that low brominated congeners might have a higher capacity to penetrate the BBB and accumulate in the brain, whereas high brominated congeners such as BDE-209 might have less potency to pass through the barrier. Further experimental studies are needed to confirm our findings.

show abstract

Section: Pbde Levels In the Brain Compared With Those In Other Tissuessupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Zhao

Qin

et al. 2016

Environmental Pollution

View full text Add to dashboard Cite

show abstract

“…As we can see, for all the seven OPFRs, concentrations in brain were always higher than in blubber, showing more affinity for the brain tissue. The same behaviour was found for BDE-153 and hexabromobenzene (Barón et al, 2015). In contrast, levels of other halogenated contaminants were higher in blubber than in brain samples (Corsolini et al, 2014).…”

Section: Tissue Distributionsupporting

confidence: 71%

“…Samples of blubber and brain included in our study were previously also analysed for determining their content on PBDEs and emerging HFRs (Barón et al, 2015). PBDEs levels in blubber ranged from 93.3 to 2045 ng/g lw, with a mean value of 1001 ng/g lw, whereas brain levels ranged from 6.87 to 791 ng/g lw, with a mean value of 205 ng/g lw.…”

Section: Opfrs Vs Pbdesmentioning

confidence: 99%

First determination of high levels of organophosphorus flame retardants and plasticizers in dolphins from Southern European waters

Sala

Giménez

Stephanis

et al. 2019

Environmental Research

Self Cite

View full text Add to dashboard Cite

This study evaluates for the first time organophosphorus flame retardant (OPFR) occurrence in the Alboran Sea delphinids (Spain). OPFRs were detected in all the individuals with concentration levels up to 24.7 µg/g lw. Twelve out of sixteen tested analytes were detected, being TBOEP which presented the highest detection frequency, and IDPP which presented the highest levels of concentration. OPFR distribution in different tissues (blubber, brain, kidney, muscle and liver) was evaluated. The pattern distribution showed the highest contribution for blubber (mean value of 68%) and the lowest contribution for liver (mean value of 2%). Seven OPFRs were detected in brain samples showing their capacity to surpass the blood-brain barrier and reach the brain. Moreover, high affinity for the brain tissue was observed. This is extremely important due to the neurotoxic effects of several compounds such as TCEP and TNBP. OPFR levels were compared with previously published PBDE concentrations, and no significant differences were observed. Taking into account the lower use and lower bioaccumulation and biomagnification capacities of OPFRs, this could indicate an additional OPFR source of pollution in addition to their use as FRs.

show abstract

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

Vella

Murphy

Giménez

et al. 2021

Aquatic Conservation

View full text Add to dashboard Cite

1. Preservation of endangered species is now recognized as a relevant component of regional and global conservation actions achieved through the maintenance of the remaining populations in a favourable conservation status. The Mediterranean common dolphin (Delphinus delphis) is listed as an Endangered subpopulation in the International Union for Conservation of Nature Red List, with declining numbers in some of the areas where it has been studied for numerous years. Prey depletion, fisheries bycatch, pollution, health risks, and climate change are among the recognized threats that the species is facing in the region.2. The existing national, regional, and international legislation pertinent to Mediterranean countries should aid greater science-policy-management integration and support innovative research and monitoring towards effective conservation. The challenges inherent in studying the pelagic D. delphis should not preclude the use of long-term, year-round, multiplatform surveys, side by side with the latest molecular tools, which aid our understanding of its populations' genetic diversity, resistance to diseases, and resilience in a semi-enclosed fast-changing sea.3. Addressing the multiplicity of problems confronting the species requires collaborative effort at all levels to share and merge resources, data, and expertise more efficiently. In this review, we provide an overview of the current knowledge on the Mediterranean common dolphin, the main threats, and knowledge gaps that are priorities for addressing its conservation, while providing clear recommendations for effectively safeguarding the species and its habitat at both local and regional levels.

show abstract

Halogenated Natural Products in Dolphins: Brain–Blubber Distribution and Comparison with Halogenated Flame Retardants

Cited by 37 publications

References 78 publications

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

Accumulation of polybrominated diphenyl ethers in the brain compared with the levels in other tissues among different vertebrates from an e-waste recycling site

First determination of high levels of organophosphorus flame retardants and plasticizers in dolphins from Southern European waters

The conservation of the endangered Mediterranean common dolphin (Delphinus delphis): Current knowledge and research priorities

Contact Info

Product

Resources

About