Halogenirani salicilanilidi - spojevi s protumetiljnim djelovanjem

Pavliček, Damir; Lugomer, Marija Denžić; Novosel, Tiana

doi:10.46419/vs.53.6.7

Cited by 1 publication

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“…The huge economic losses caused by the disease are mainly due to the reduction in milk yield and quality, the need for expensive treatments, and even cow mortality [2,3]. Even worse, Animals 2023, 13, 741 2 of 13 veterinary drug overuse to cure mastitis could soon pose a threat to humans, linked to antibiotic residues [4][5][6][7][8]. At the population level, the California mastitis test (CMT) is used to estimate milk somatic cell count (SCC), which is widely accepted as a convenient and rapid method in mastitis diagnosis [9].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Analysis of Multiple Biological Specimens (Feces, Serum, and Urine) by 1H-NMR Spectroscopy from Dairy Cows with Clinical Mastitis

Zhu

Zhang

Xin

et al. 2023

Animals

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Due to huge economic losses to the dairy industry worldwide, mastitis can be considered as one of the most common diseases in dairy cows. This work aimed to study this disease by comparing multiple biological specimens (feces, serum, and urine) from individuals with or without clinical mastitis. This was performed by a single analytical platform, namely 1H-NMR, through a multi-matrix strategy. Thanks to the high reproducibility of 1H-NMR, we could characterize 120 molecules across dairy cow feces, serum, and urine. Among them, 23 molecules were in common across the three biofluids. By integrating the results of multi-matrix metabolomics, several pathways pertaining to energy metabolism and amino acid metabolism appeared to be affected by clinical mastitis. The present work wished to deepen the understanding of dairy cow mastitis in its clinical form. Simultaneous analysis of metabolome changes across several key biofluids could facilitate knowledge discovery and the reliable identification of potential biomarkers, which could be, in turn, used to shed light on the early diagnosis of dairy cow mastitis in its subclinical form.

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