Haloperidol-induced disruption of retrieval behavior and reversal with apomorphine in lactating rats

Giordano, Anthony L.; Johnson, Allan E.; Rosenblatt, Jay S.

doi:10.1016/0031-9384(90)90288-f

Cited by 106 publications

(68 citation statements)

References 15 publications

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“…Dopamine-depleting 6-OHDA lesions of the n. Acc or the DA cell bodies in the VTA significantly disrupt maternal behavior (Hansen et al, 1991;Hansen, 1994). Infusions of D 1 and D 2 receptor antagonists into the n. Acc reduces pup retrieval and LG (Giordano et al, 1990;Hansen et al, 1991;Stern and Taylor, 1991;Keer and Stern, 1999). Interestingly, the n. Acc is broadly implicated in the processes of incentive motivation and mediates appetitive behaviors toward a wide range of "natural" reinforcers (Mitchell and Gratton, 1992;Robbins and Everitt, 1996;Ikemoto and Panksepp, 1999).…”

Section: Introductionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

332

257

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Section: Introductionmentioning

confidence: 99%

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Champagne

Chretien²,

Stevenson³

et al. 2004

J. Neurosci.

332

257

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“…DA plays a major role in the maternal behavior of lactating rats (Giordano et al, 1990) and its actions in reward-related circuitry of the basal forebrain (e.g., within the ventral pallidum) are necessary for pair bond formation in monogamous prairie voles, Microtus orchrogaster (Aragona et al, 2003). DA agonists also facilitate defensive aggression in cats (Maeda et al, 1985).…”

Section: Introductionmentioning

confidence: 99%

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

2006

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Dopamine (DA) is produced in numerous brain areas and influences a wide variety of social behaviors, but very few data are available to establish the socially-relevant response properties of most DA populations, which comprise eight cell groups numbered A8-A15. Anatomically, these DA populations are evolutionarily conserved, and all have been identified in both birds and mammals. We now report the Fos responses of tyrosine hydroxylase-immunoreactive (TH-ir; putatively dopaminergic) neurons in the A8-A15 cell groups of male zebra finches following exposure to a control condition or one of six different social stimuli: A heterospecific male, conspecific male, fighting in a mate competition paradigm (which includes both male and female stimuli), a courtship interaction without physical contact, a courtship interaction with physical contact but no mounting, and a courtship interaction with mounting. We found that the DA cell groups exhibit distinctive profiles of responsiveness to social stimuli. Fos induction in A8, A9, A10 and midbrain A11 neurons increased significantly in response to a variety of conspecific stimuli, but not heterospecific stimuli. In contrast, Fos induction in the preoptic A14 neurons was observed specifically in response to sexual interactions, and Fos induction in hypothalamic A11 neurons appears to primarily reflect the performance of courtship singing. Infundibular A12 neurons, which may be involved in stress-related processes, showed the highest level of TH+Fos colocalization in control subjects. This colocalization decreased in response to all conspecific stimuli except fighting, and did not decrease following exposure to a heterospecific male. Keywords dopamine; forebrain; aggression; sexual behavior; tyrosine hydroxylase; Fos Dopamine (DA) is known to influence a variety of social behaviors, particularly male sexual behavior, in multiple vertebrate groups (Warner et al., 1991;Pomerantz, 1992;Absil et al., 1994;Hull et al., 1995;Dominguez et al., 2001;Woolley et al., 2001;Melis et al., 2003;Charlier et al., 2005), and DA cells are distributed in homologous groups across the vertebrate classes (Bailhache and Balthazart, 1993;Bottjer, 1993;Gonzalez and Smeets, 1994;Reiner et al., 1994;Tillet, 1994;Appeltants et al., 2001;Adrio et al., 2002). This similarity across vertebrates is particularly clear when comparing mammals and birds, which each have dopaminergic neurons (immunopositive for tyrosine hydroxylase, TH, and immunonegative for dopamine β-hydroxylase) localized to eight populations of the basal forebrain and brainstem numbered A8 through A15 (Reiner et al., 1994;Tillet, 1994). However, it is largely unknown how these various DA populations respond to a broad range of social stimuli, so we have here examined DA neuronal responses to a variety of interactions with heterospecific and conspecific animals. Extensive data suggest that the release of DA into the preoptic area (POA) controls male sexual behavior. Administrations of the DA agonist apomorphine into the medial POA faci...

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“…O comportamento de trazer os filhotes para o ninho é o parâmetro mais frequentemente quantificado do CM em ratos, e consiste em uma sequência motora repetitiva que depende de DA (STERN, 1989;STERN, 1996). Injeções sistêmicas de antagonistas competitivos de DA (0,2 mg/Kg) como o haloperidol ou raclopride dose dependentemente aumentam o tempo para trazer os filhotes para o ninho (GIORDANO et al, 1990;KEER, 1999;SILVA et al, 2001;LONSTEIN, 2002). Nos dois casos esse efeito foi revertido pela administração de 0,1 mg/Kg de apomorfina um agonista dopaminérgico (GIORDANO et al, 1990).…”

Section: Dopamina E Comportamento Maternalunclassified

“…Injeções sistêmicas de antagonistas competitivos de DA (0,2 mg/Kg) como o haloperidol ou raclopride dose dependentemente aumentam o tempo para trazer os filhotes para o ninho (GIORDANO et al, 1990;KEER, 1999;SILVA et al, 2001;LONSTEIN, 2002). Nos dois casos esse efeito foi revertido pela administração de 0,1 mg/Kg de apomorfina um agonista dopaminérgico (GIORDANO et al, 1990). Outros componentes motores do CM como construção de ninho e comportamento de limpeza dos filhotes são inibidos pela administração sistêmica de haloperidol (GIORDANO et al, 1990; …”

Haloperidol-induced disruption of retrieval behavior and reversal with apomorphine in lactating rats

Cited by 106 publications

References 15 publications

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Variations in Nucleus Accumbens Dopamine Associated with Individual Differences in Maternal Behavior in the Rat

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

<b>Influência do LPS e do zinco na interação mãe e filhote</b>

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