In the face of escalating pressures from climate change, environmental degradation, and escalating pest and disease burdens, traditional agricultural practices are proving insufficient to ensure food security and sustainable crop production. Nanoomics, a pioneering interdisciplinary field, offers a promising avenue for addressing these challenges by harnessing the unique properties of nanomaterials and integrating economic principles to devise innovative solutions. By addressing both abiotic and biotic stresses, this chapter delves into the diverse strategies and mechanisms employed to enhance crop resilience and productivity. Through a multidisciplinary approach encompassing nanoscience, plant biology, and agricultural economics, this chapter examines the synthesis, characterization, and deployment of nanomaterials for stress detection, monitoring, and mitigation.