Halothane and carbohydrate metabolism

Keating, V. J.; Patrick, S. J.; Annamunthodo, H

doi:10.1111/j.1365-2044.1959.tb13783.x

Cited by 9 publications

(1 citation statement)

References 3 publications

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“…This fact is, of course, manifested more obviously in clinical anaesthesia by hypotension and peripheral vasodilatation, but it would seem that the basic mechanism in both hypotension and relative absence of blood sugar change is the same. Since this work was completed Keating (1959) has published evidence that the blood sugar content rises in Jamaicans under the influence of halothane. It is, however, to be noted that the rise in his cases, though undoubtedly significant, was not commensurate with that occurring with diethyl ether anaesthesia, nor are die final blood sugar levels greatly different from those reported in the present series.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Irregularities in Cats Under Halothane Anaesthesia

Muir

Hall

Littlewort

1959

British Journal of Anaesthesia

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Section: Discussionmentioning

confidence: 99%

Cardiac Irregularities in Cats Under Halothane Anaesthesia

Muir

Hall

Littlewort

1959

British Journal of Anaesthesia

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Circulating Glucose and Insulin in Surgery for Insulomas

Schnelle¹

1971

JAMA

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Blood glucose levels during methoxyflurane anaesthesia

Gottlieb¹,

Sweet²

1964

Can Anaes Soc J

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HYPERGLYCAEMIA has long been recogmzed as one of. the chmf responses to the metabohc stress of anae~thesaa Dlethyl ether especmlly will produce increases 1 n the blood sugar of ut to 100 per cent during the fllrst half-hour to 45 minutes o[~anaeskhesaa and for th~s reason ats effect on carbohy[drat{, metabohsm has been s~Ldled extensively 1 Experiments done on dogs m th~l' 192,0 s seemed to mdmate that thus hyperglycaemm was related to, or caused by, a profound metabohe aeLdosls which appeared qmte early during the adm~l~astratmn of ether 2 a 4 This e:cplanaaon was w,~dely accepted as applying to man until Beecher and his co-workers demonstrated that ~her~ is no slgmficant metabohe acidosis during the admmastrahon of efher to adults, although some degree of acidosis does occur m children 5 e Prior to Beecher's reports, at hgd been shown m rabbats that both adrenalectom)i and spinal anaesthesaa prelducmg a T4 sensory level woutd protect against hyperglycaemaa during ether anaesthesm 7 This observation has been confirmed repeatedly by the use of beth local anaesthetms and a,drenergm blocking agents s 0 Today, therefore, it ~as generally concluded that ihe hyperglycaemm produced by ether anaesthesm as mostly the result of the hberatton of catecholammes ~oOther general anaestheaes are also capable of p~loduemg a hyperglycaemm l esponse Cyclopropane anaesthesm m man cheats an increase m the Mood sugar %ompa~able to that reduced by ether" according to Greene al Reports concernmg "the effect of halothane are somewhat davergent Some studms have shown no effect on blood sugar during halothane anaesthe,,m, while other evaluatmns have shown that there as some hype~:glycaemm response to halothane m This, however, as not as great as that seen wath ether and cyelopropane ~ ~4 It is of anterest to note that the hyperglycaem~a produced by these agents seems to para~el thear effect on sympathetic actrvlty, for~ at has been shown that both ether and cyclowopane produce a marked increase m the level of circulating cateeholammes, wh~le halothane does not ~5 Methox),flurane combines some of the structural and anaesthetm charactenstacs of both dlethyl ether and halothane, smee at as a halogenated methyl ethyl e~mr Its effect on carbohydrate metabohsm, however, has not yet been studmd care}ully In one early report of a chmeal trml of methoxyflu~ane in 20~ patmnts the b]ood sugar was measured an ~ In 8 of these a moderate rise of about 85 mg ~g occurred 1~ Another study with dogs indicated that Mood sugar was unchanged during spontaneous respiration but decreased wath a~s~sted resp~ratmn ~7 ~From the Department of Anesthesiology, 'The Umverslty of Mmhlgan MedmaI School, Veterans Administration Hospital, Ann Arbor, Michigan 7 Can Anaes S~c J, vo] 11, no 1, Jam~ary, !964

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Halothane and carbohydrate metabolism

Cited by 9 publications

References 3 publications

Cardiac Irregularities in Cats Under Halothane Anaesthesia

Cardiac Irregularities in Cats Under Halothane Anaesthesia

Circulating Glucose and Insulin in Surgery for Insulomas

Blood glucose levels during methoxyflurane anaesthesia

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