2006
DOI: 10.1016/j.tox.2006.07.013
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Halothane induces oxidative stress and NF-κB activation in rat liver: Protective effect of propofol

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Cited by 43 publications
(38 citation statements)
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“…This experiment showed that propofol 50 mg·kg -1 ip), a dose which inhibits rat hippocampal acetylcholine release to a lesser extent than does propofol 100 mg·kg -1 ip, 19 produced a sedative response in rats, as determined by loss of reflex responses to a painful stimulus (needle skin prick), while remaining sensitive to skin incision. As propofol 60 mg·kg -1 ip, provides satisfactory anesthesia in rats, 20 we selected a slightly lower dose based on our preliminary study. Also, during the preliminary experiment, we found that neither intralipid nor physiological saline influenced the extent of intestinal mucosal damage in the injury group.…”
Section: Experimental Protocolmentioning
confidence: 99%
“…This experiment showed that propofol 50 mg·kg -1 ip), a dose which inhibits rat hippocampal acetylcholine release to a lesser extent than does propofol 100 mg·kg -1 ip, 19 produced a sedative response in rats, as determined by loss of reflex responses to a painful stimulus (needle skin prick), while remaining sensitive to skin incision. As propofol 60 mg·kg -1 ip, provides satisfactory anesthesia in rats, 20 we selected a slightly lower dose based on our preliminary study. Also, during the preliminary experiment, we found that neither intralipid nor physiological saline influenced the extent of intestinal mucosal damage in the injury group.…”
Section: Experimental Protocolmentioning
confidence: 99%
“…The reactive oxygen species were hydrogen peroxide, superoxide anion, peroxide radicals, alkoxy radical and peroxy radical. Reactive nitrogen species were nitric oxide and peroxynitrite (Brasil et al, 2006). The production of these free radicals was favoured directly by reduced perfusion and tissue anoxia and indirectly by anaesthetic and ancillary drugs (Basu et al, 2001 andOzer andKaman, 2007).…”
Section: Antioxidantsmentioning
confidence: 99%
“…The free radicals were released from cytochrome P450, endothelium, granulocytes, macrophages and red blood corpuscles. Free radicals caused stress, inflammation, delay in wound healing, prolonged recovery from anaesthesia and post anaesthetic complications due to the insult on the functional ability of heart, lung, spleen, liver, kidney, red blood corpuscles and muscles (Brasil et al, 2006). The half-life of free radicals is 10 -6 to 10 -9 seconds at 37 0 C except hydrogen peroxide; hence the level of free radicals was indirectly assessed by the directly proportional activity of enzymatic antioxidants namely SOD, GPx and CAT and non enzymatic antioxidants -GSH (Delogu et al, 2004).…”
Section: Antioxidantsmentioning
confidence: 99%
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