Halothane, surgery, immunosuppression and artificial pulmonary metastases

Lundy, Joel; Lovett, Edmund J.; Hamilton, Susan; Conran, Philip B.

doi:10.1002/1097-0142(197803)41:3<827::aid-cncr2820410307>3.0.co;2-#

Cited by 66 publications

(21 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Numerous studies (Kurosawa S, 2008) have shown that recently, alongside with immune suppression caused by surgical stress, anaesthetics and analgesic agents commonly used in surgery and in intensive care may directly affect the functions of immune-competent cells. Since the reactivation of HHV-6 and HHV-7 viral infection is more pronounced in patients of general anaesthesia group, our data are consistent with the previous studies that general anaesthesia does not suppress the surgical stress response, thus exacerbating postoperative immunosupression (Stevenson, 1990), (Lundy, 1978). Immunosupression is the main cause of the reactivation of HHV-6 and HHV-7 viral infection.…”

Section: Discussionsupporting

confidence: 92%

The Detection of Beta-Herpesvirus Infection in Patients undergoing Reconstructive Flap Surgeries and Its Association with the nearest Postoperative Period Course

Vilks¹,

Rasa²,

Krustins³

et al. 2011

Acta Chirurgica Latviensis

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 92%

The Detection of Beta-Herpesvirus Infection in Patients undergoing Reconstructive Flap Surgeries and Its Association with the nearest Postoperative Period Course

Vilks¹,

Rasa²,

Krustins³

et al. 2011

Acta Chirurgica Latviensis

View full text Add to dashboard Cite

“…It has been reported in the literature that surgery may cause immunosuppression, 24,25 consistent with an increase in the rate of metastases. However, following surgery in this model, the rates of metastases in the lung and groin were lower and higher, respectively, compared with untreated control but these differences were not statistically significant.…”

Section: The Response Of Distant Metastasis To Local Pd-bpheid-pdt Ofmentioning

confidence: 71%

Local photodynamic therapy (PDT) of rat C6 glioma xenografts with Pd‐bacteriopheophorbide leads to decreased metastases and increase of animal cure compared with surgery

Schreiber

Gross

Brandis

et al. 2002

Intl Journal of Cancer

106

View full text Add to dashboard Cite

Photodynamic therapy (PDT), locally applied to solid C6 rat glioma tumors in the foot of CD1 nude mice, eradicated the primary tumor and also decreased the rate of groin and lung metastases. Pd-Bacteriopheophorbide (Pd-Bpheid), a novel photosensitizer synthesized in our laboratory, was used in our study. The primary lesion in the hind leg was treated by an i.v. injection of 5 mg/kg of Pd-Bpheid and immediate illumination (650 -800 nm, 360 J/cm 2 ). This protocol and the surgical amputation of the leg were compared for local and metastasis responses. Following PDT, hemorrhage, inflammation with tumor necrosis and flattening were observed and histologically verified in the photodynamically treated tumor. Whereas local tumor control rates were up to 64% following PDT, in surgically treated animals, local tumor control was absolute. The rates of metastases in the groin and the lungs were at least 12-fold lower in the photodynamically treated animals compared with untreated or surgerytreated groups. The overall cure rates after PDT or surgery were 36% and 6%, respectively, at 8 weeks. These findings suggest that local PDT with Pd-Bpheid, which acts primarily on the tumor vasculature, efficiently eradicates the solid C6 tumors. In addition, the local PDT of the primary lesion has beneficial therapeutic effects on remote C6 metastasis, which is not obtained with surgery. It is therefore suggested, that although surgery is highly efficient for the immediate removal of the primary tumor, it lacks such systemic, therapeutic effects on distant metastases. Pd-Bpheid-PDT may thus offer a potentially superior curative therapy for C6 glioma tumors in the limb by eradicating the target tumor and by reducing the rate of metastasis in the groin and lung, possibly due to innate immunity. © 2002 Wiley-Liss, Inc. Key words: photodynamic therapy; surgery; Pd-bacteriopheophorbide; C6 glioma tumor; metastasisPhotodynamic therapy (PDT) is based on the destruction of tumors by cytotoxic reactive oxygen species (ROS) produced upon local tumor illumination in patients administered with a photosensitizer. 1-3 Following health agency approval for photofrin-based PDT in many countries, this anti-cancer treatment modality entered clinical use for the local treatment of an increasing number of indications including skin, esophageal, lung, gastric, cervical and bladder cancers. 4 PDT is usually considered a local anti-tumor treatment modality. However, reports from several laboratories suggest that PDT also induces beneficial systemic effects. Following in vitro hematoporphyrin-based PDT, adhesiveness and metastatic potential decline in DHD-K12-cultured colon carcinoma cells. Moreover, intravenous or s.c. injection of these PDT-treated cells to rats resulted in a reduced number of lung metastases compared with untreated cell injection. 5,6 Although this observation may be due to local photodynamic damage, the potential beneficial effect may be viewed as systemic. Other in vivo studies showed that local PDT with various photosensitizers mediates ...

show abstract

“…However, his observations are well aligned with studies from more than four decades ago, when the association between volatile anesthetics and neoplasm progression was first observed. Lundy et al proposed that the combination of halothane, surgery and immunosuppression increased pulmonary metastases in mice inoculated with tumor cells [4]. Shapiro et al found that lung tumor progression was accelerated in mouse models when exposed to halothane and nitrous oxide [5].…”

Section: The Effect Of General Anesthesia On Cancer Recurrencementioning

confidence: 99%

Anesthetic Considerations for Management of Cancer Patients to Decrease Cancer Recurrence

Laudański¹,

Wei²,

Korley³

2016

J Anesth Clin Res

View full text Add to dashboard Cite

Alongside the known direct, short-term effects of anesthesia in general, there is emerging evidence of an immunomodulatory effect with specific anesthetics that may decrease patient's defences against malignant neoplastic growths. This effect is especially important in the setting of surgical management of neoplasms, which is often the best option for long-term survival in patients with solid neoplasm. Many studies have speculated on the best anesthetic technique to reduce the neoplasm recurrence and promote patient survival, however, we often neglect the sympathetic stress response to neoplasia and how anesthetics modulate this effect. In this review, we study the evidence as it pertains to anesthetic techniques and pain control, particularly general vs. regional anesthesia, and opioid analgesia. At this time there is not enough evidence to support that regional anesthesia has a more favorable outcome than general anesthesia, or that opioids should not be used in neoplasm-related pain management because of their potential pro-metastatic properties secondary to opioid-induced immunosuppression. Instead, the debate over anesthetic use should be centered on adequate pain control since overwhelming evidence have shown that pain-related stress reaction mediated via β-adrenergic activation, promotes neoplastic propagation and metastasis, hence decreasing survival rates.

show abstract

Halothane, surgery, immunosuppression and artificial pulmonary metastases

Cited by 66 publications

References 9 publications

The Detection of Beta-Herpesvirus Infection in Patients undergoing Reconstructive Flap Surgeries and Its Association with the nearest Postoperative Period Course

The Detection of Beta-Herpesvirus Infection in Patients undergoing Reconstructive Flap Surgeries and Its Association with the nearest Postoperative Period Course

Local photodynamic therapy (PDT) of rat C6 glioma xenografts with Pd‐bacteriopheophorbide leads to decreased metastases and increase of animal cure compared with surgery

Anesthetic Considerations for Management of Cancer Patients to Decrease Cancer Recurrence

Contact Info

Product

Resources

About