Hamartoma of the lung

Koutras, Phoebus; Urschel, Harold C.; Paulson, Donald L.

doi:10.1016/s0022-5223(19)42183-1

Cited by 41 publications

(10 citation statements)

References 47 publications

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“…It was firstly used in 1904 by Albrecht [ 17 ] to define tumor resulting from an error in development of tissues normally present in the involved organ. In 1934, Goldsworthy defined PH as a benign tumor composed of a combination of fat and cartilage [ 1 , 2 ]. The clinical significance of PH is still debate with concerns on malignant degeneration or association with lung cancer.…”

Section: Discussionmentioning

confidence: 99%

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Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Fiorelli

D’Andrilli

Carlucci

et al. 2021

Lung

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Purpose Pulmonary hamartoma is the most common benign tumor of the lung. We analyzed a 20-year historical series of patients with pulmonary hamartoma undergoing surgical resection, aiming to evaluate the characteristics, the outcomes, and the association between hamartoma and lung cancer. Methods It was a retrospective multicenter study including the data of all consecutive patients with pulmonary hamartoma undergoing surgical resection. The end-points were to evaluate: (i) the characteristics of hamartoma, (ii) outcomes, and (iii) whether hamartoma was a predictive factor for lung cancer development Results Our study population included 540 patients. Upfront surgical or endoscopic resection was performed in 385 (71%) cases while in the remaining 155 (29%) cases, the lesions were resected 20 ± 3.5 months later due to increase in size. In most cases, lung sparing resection was carried out including enucleation (n = 259; 48%) and wedge resection (n = 230; 43%) while 5 (1%) patients underwent endoscopic resection. Only two patients (0, 2%) had major complications. One patient (0.23%) had recurrence after endoscopic resection, while no cases of malignant degeneration were seen (mean follow-up:103.3 ± 93 months). Seventy-six patients (14%) had associated lung cancer, synchronous in 9 (12%) and metachronous in 67 (88%). Only age > 70-year-old (p = 0.0059) and smokers > 20 cigarettes/day (p < 0.0001) were the significant risk factors for lung cancer. Conclusion PH was a benign tumor, with no evidence of recurrence and/or of malignant degeneration after resection. The association between hamartoma and lung cancer was a spurious phenomenon due to common risk factors.

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Section: Discussionmentioning

confidence: 99%

“…Pulmonary hamartoma (PH) is the most common benign tumor of the lung, accounting for 3% of all lung tumors and having an incidence of 0.25% in the general population [1][2][3][4][5]. PH has been initially considered a developmental malformation, but at present it is classified as a true benign mesenchymal tumor [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Fiorelli

D’Andrilli

Carlucci

et al. 2021

Lung

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“…PH occurs most frequently in the patients aged from 40 to 70 years, with a variation in male preponderance from 2: 1 to 4: 1 [ 4 , 15 ], this maybe due to the higher morbility of pulmonary disease in male. In our series, the ratio was 2.25: 1, and 21 patients (53.8%) had heavy smoking history.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment and outcome of pulmonary hamartoma: a retrospective study of 20-year experience

Guo

Zhao

Jiang

et al. 2008

J Exp Clin Cancer Res

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Background: Controversy still exists in the indication and timing of surgical treatment of pulmonary hamartoma (PH). The objective of this study is to summarize the experience and the outcome of the surgical treatment for pulmonary hamartomas, and to assess the effectiveness and necessity of surgical therapy administered in patients with pulmonary hamatoma as well as clinical and pathological features and long-term follow-up results.

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“…The majority 01' hamartomas 01' the Jung are found in the peripheral parenchyrna, although a few are loeated in the bronehi. Most cornmonly, intrapulmonary hamartomas prescnt as asymptomatie pulmonary lesion s noted on x-ray examination 01' the ehest (6,9). On thc other hand, endebronchial hamartomas produce symptoms such as fcvcr, dyspnoea, wheezing, and haernoptysis (8).…”

Section: Discussionmentioning

confidence: 99%

“…Stipp led or popcornlike calcifications are scen in about 10 ('i ' il ofpulmonary hamartomas (3). The roent genographie appea ranee 01' endobronehial hamartoma is usually that 01' an ohstruetive lesion eausing distal ateleetasis or pneumonia (3,6).…”

Section: Discussionmentioning

confidence: 99%

The Adult Type Pulmonary Hamartoma in an 11-Year-Old Boy

Yamazaki¹,

Yasukawa²,

Mizuno³

et al. 1986

Eur J Pediatr Surg

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Hamartoma of the lung occurs most often in persons after the age of 40, but quite rarely among children. This paper reports on an 11-year-old boy with a pulmonary hamartoma in the right upper lobe. The patient was asymptomatic, but a well demarcated, solitary, lobulated nodule with a "popcorn"-shaped calcification was visualised on chest x-ray film. An upper lobectomy was carried out to remove the lesion. The post-operative course was uneventful. Two years post-operatively, the child was symptom-free and has been developing normally.

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Hamartoma of the lung

Cited by 41 publications

References 47 publications

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Pulmonary Hamartoma Associated With Lung Cancer (PHALC Study): Results of a Multicenter Study

Surgical treatment and outcome of pulmonary hamartoma: a retrospective study of 20-year experience

The Adult Type Pulmonary Hamartoma in an 11-Year-Old Boy

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