Cancer patients have special communication needs. Therapeutic communication can help patients, families, and care teams make decisions and improve patients' well-being and quality of life. This study aimed to understand the therapeutic communication experience of nurses with patients undergoing chemotherapy. This study employed a descriptive phenomenology design using in-depth interviews involving eight key participants and one associate participant. The key participants were nurse practitioners, and the associate participant was the vice head of the chemotherapy ward. The results of interviews and field notes were analyzed using Colaizzi's method of data analysis. Nine themes emerged from this study that is therapeutic communication is perceived as beneficial for patients, therapeutic communication is perceived as useful for nurses, patient conditions that hinder therapeutic communication, nurse conditions that interfere with therapeutic communication, personal therapeutic communication strategies, interpersonal therapeutic communication strategies, regular chemotherapy training, training for ongoing therapeutic communication, and chemotherapy-related information media to facilitate therapeutic communication. The study results suggest the need for chemotherapy training and continuous therapeutic communication for nurses in the chemotherapy ward of a general hospital.