Hamman-Rich Syndrome Revisited

Olson, June; Colby, Thomas V.; Elliott, C. Gregory

doi:10.1016/s0025-6196(12)62187-9

Cited by 189 publications

(180 citation statements)

References 18 publications

Supporting

Mentioning

165

Contrasting

Unclassified

Order By: Relevance

“…(72) Patients with AIP present progressive respiratory symptoms and respiratory insufficiency occurring over the course of days to weeks. The disease is distinguished from other forms of DAD by the absence of an identifiable cause or predisposing disease.…”

Section: Clinical Managementmentioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

View full text Add to dashboard Cite

High-resolution computed tomography (HRCT) is the radiological imaging technique best suited to revealing changes in lung structure. Various HRCT findings, taken together, can represent typical patterns. These patterns, in conjunction with the anatomical distribution of findings and with clinical data, can narrow the differential diagnosis of diffuse interstitial lung disease and, in many cases, indicate the correct diagnosis with a high degree of accuracy. The most common HRCT patterns seen in cases of diffuse interstitial lung diseases are the nodular pattern, linear/reticular opacities, cystic lesions, ground-glass opacities and consolidations. This article reviews the correlations between HRCT patterns and pathologic findings, summarizing the most common causes, as well as detailing the methods of investigation employed in order to diagnose the most common types of chronic diffuse lung disease.Keywords: Lung diseases, interstitial/pathology; Tomography, X-Ray computed; Diagnostic techniques, respiratory system. ResumoA tomografia de alta resolução (TCAR) é a técnica de imagem radiológica que reflete mais de perto as alterações da estrutura pulmonar. Os vários achados tomográficos podem ser combinados para formar padrões típicos. Estes, conjuntamente com a distribuição anatômica dos achados, e com os dados clínicos, podem estreitar o diagnóstico das doenças intersticiais pulmonares difusas, e em vários casos sugerir o diagnóstico correto com alto grau de acurácia. Os padrões mais comuns das doenças intersticiais pulmonares difusas na TCAR são o nodular, linear e reticular, lesões císticas, opacidades em vidro fosco e consolidações. Este artigo revisa as correlações entre os padrões tomográficos na TCAR e os achados patológicos e resume as causas mais comuns e os métodos de investigação para se atingir um diagnóstico nas doenças pulmonares crônicas difusas mais comuns.Descritores: Doenças pulmonares intersticiais/patologia; Tomografia computadorizada por raios X; Técnicas de diagnóstico do sistema respiratório.* Study carried out in the

show abstract

Section: Clinical Managementmentioning

confidence: 99%

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Acute interstitial pneumonia (formerly Hamman-Rich syndrome) has been added to the classification of idiopathic interstitial pneumonia [10,II], making the current classification of three clinicopatho logically distinct entities: usual interstitial pneumonia, desquamative interstitial pneu monia, and acute interstitial pneumonia [12]. However, a group of idiopathic interstitial pneumonias that cannot be classified opti mally into oneof the threemain entitiescon stitutes another entity, termed â€oe¿ nonspecific interstitial pneumonia with fibrosis,â€• or â€oe¿ nonclassifiable interstitial pneumoniaâ€• [13].…”

mentioning

confidence: 99%

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Kim¹,

Lee²,

Chung³

et al. 1998

American Journal of Roentgenology

164

View full text Add to dashboard Cite

OBJECTIVE. The purposeof our studywas to describehigh-resolutionCT findingsof nonspecific interstitial pneumonia with fibrosis and to compare findings seen on CT with pathologic findings. MATERIALS AND METHODS. High-resolutionCT findingsof biopsy-provennonspecific interstitial pneumonia with fibrosis from 23 consecutive patients (one man and 22 women) were analyzed retrospectively by two chest radiologists. CT findings were compared with pathologic findings.RESULTS. The predominant high-resolution CT finding,seenin all patients,wasbilateral patchy areasof ground-glass opacity with (35%) or without (65%) areasof consolidation. Ir regular linear opacities (87%), thickening of bronchovascular bundles (65%), and bronchial dilatation (52%) were also frequently seen. Honeycombing was not seen in any patient. All parenchymal abnormalities showed subpleural predominance. Areas of ground-glass opacity with or without irregular linear opacity or bronchial dilatation on CT correspondedpathologi cally to areasof interstitial thickening causedby varying degreesof interstitial inflammation and fibrosisshowingtemporaluniformity.Areas of consolidation, seenat five biopsysites, represented the areas of bronchiolitis obliterans organizing pneumonia, foamy cell collections in alveolar spaces,or microscopic honeycombing with mucin stasis. CONCLUSION.On high-resolutionCT, nonspecificinterstitialpneumoniawith fibrosis is most commonly revealed as patchy subpleural areasof ground-glass opacity mixed with ir regular linear opacity or bronchial dilatation. These areas represent interstitial thickening caused by varying degrees of interstitial inflammation, fibrosis, or both.

show abstract

“…As seen in Table 2, these patients had typical pulmonary features of ARDS, including severe dyspnea, interstitial and alveolar radiographic changes, marked hypoxemia necessitating a high FiO, and PEEP for adequate oxygenation, hemodynamic parameters of noncardiogenic pulmonary edema, and poor lung compliance (10). Evaluation for infectious or noninfectious etiologies of ARDS was unrevealing.…”

Section: Discussionmentioning

confidence: 95%

Adult respiratory distress syndrome in polymyositis patients with the anti–jo‐1 antibody

Clawson

Oddis

1995

Arthritis & Rheumatism

View full text Add to dashboard Cite

We report 3 patients with polymyositis and the anti-Jo-1 antibody who developed fatal adult respiratory distress syndrome (ARDS). Other than the presence of the anti-Jo-1 antibody, there were no other consistent clinical features at the onset of disease that were predictive of ARDS development.The inflammatory myopathies are a heterogeneous group of idiopathic, chronic inflammatory disorders of skeletal muscle. Pulmonary involvement in myositis may be primary (interstitial lung disease; ILD) or secondary to respiratory muscle weakness or other organ involvement (e.g., pulmonary edema due to heart failure or aspiration due to the proximal dysphagia of pharyngeal involvement). Drug-induced pneumonitis or pulmonary fibrosis as well as bacterial or opportunistic infections also lead to pulmonary complications (1).ILD is commonly associated with the inflammatory myopathies (2,3). The clinical characteristics of ILD in myositis are similar to those observed in primary forms of ILD or other connective tissue diseases. A severe, rapidly progressive, and fatal diffuse alveolitis may occur, but most patients have a mild, slowly progressive form of ILD. Occasionally, patients have only asymptomatic radiographic changes, such as bibasilar fibrosis or minor abnormalities in pulmonary function testing.A unique feature of ILD in myositis is its strong association with the anti-aminoacyl-transfer RNA (tRNA) synthetase autoantibodies (4). The anti-Jo-1 antibody is the most frequently identified myositisSupported by a grant from the Commonwealth of Pennsylvania, Department of Health.Kevin Clawson, DO, Chester V. Oddis, MD: University of Pittsburgh, Pittsburgh, Pennsylvania.Address reprint requests to Chester V. Oddis, MD, Medicine/Rheumatology, University of Pittsburgh, 3471 Fifth Avenue, Suite 502, Pittsburgh, PA 15213-3221.Submitted for publication December 16, 1994; accepted in revised form April 8, 1995. specific antibody, and is the most common of the group of anti-aminoacyl-tRNA synthetases. It is found in approximately 20% of patients with myositis (9, and is itself directed against histidyl-tRNA synthetase. The onset of illness in anti-Jo-1 antibody-positive patients is often rapid, with any combination of symptoms, including fever, Raynaud's phenomenon, "mechanic's hands," polyarthritis, myositis, and ILD. The response to therapy in this subset of myositis patients has been poor; relapses are frequent and the 5-year cumulative survival is less than 70% (6).In the present report, we describe 3 patients with the anti-Jo-1 antibody who developed rapidly progressive respiratory failure and fatal adult respiratory distress syndrome (ARDS). CASE REPORTSPatient 1. Patient 1, a 64-year-old white woman, developed fatigue, muscle weakness, myalgias, and arthritis in October 1993. One month later, she was admitted to a local hospital with fever and proximal dysphagia. The initial examination revealed a body temperature of 38.8"C, orthostatic hypotension, inspiratory rales, and moderate proximal muscle weakness. The hemogram, ery...

show abstract

Hamman-Rich Syndrome Revisited

Cited by 189 publications

References 18 publications

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Padrões tomográficos das doenças intersticiais pulmonares difusas com correlação clínica e patológica

Nonspecific interstitial pneumonia with fibrosis: high-resolution CT and pathologic findings.

Adult respiratory distress syndrome in polymyositis patients with the anti–jo‐1 antibody

Contact Info

Product

Resources

About