Hämolytische Krise mit akutem Nierenversagen unter Rifampicin-Behandlung

Acute Renal Failure After Rifampicin: a Case Report and Survey of the Literature

“…Clinical histories very similar to each other have been described by a number of authors [3,[8][9][10]16,[22][23][24][25]29,32,36,39,44]; the most striking feature was that, some time after the end of a rather long and uneventful course of daily treatment, a single low dose of the drug was sufficient to elicit a severe reaction followed by renal failure. In four cases [3,10,22,29,44], the challenge dose of rifampicin was taken by the patient on his own initiative; one patient of this group [3] died with digestive hemorrhage 19 days after the onset of renal symptoms.…”

“…The direct Coomb's test was found to be positive by H asse et al [20], whose patient experienced also a severe hemolytic crisis and by K rônig et al [23,24] ; Talin d 'Eyzac et al [44] and Beruard et al [3] obtained positive results with the indirect Coomb's test while Campese et al [7] found negative results for both the direct and in direct Coomb's tests. Serum antirifampicin antibodies, investigated by means of antiglobulin techniques, have been found in the patients of Poole et al [35] and Stradling [41], K leinknecht et al [22], Decroix et al [10], Lakshminarayan et al [25], Môhring et al [32], Germann et al [16].…”