Hamster Sexually Mature at Twenty-Eight Days of Age

Selle, Raymond M.

doi:10.1126/science.102.2654.485

Cited by 12 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the relative use of hamsters in research has declined over the years, they are uniquely suited for reproductive studies. Female hamsters are polyestrous, and their sexual maturity begins around 4 weeks of age [94]. In mice, both uterine horns open in a common vagina [95], but a dual vagina is present in rats, rabbits, guinea pigs and hamsters [96].…”

Section: Hamsters As Preferred Models For Implantation Studiesmentioning

confidence: 99%

The hamster as a model for embryo implantation: Insights into a multifaceted process

Reese

Wang

Ding

et al. 2008

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

Defects in preimplantation embryonic development, uterine receptivity, and implantation are the leading cause of infertility, pregnancy problems and birth defects. Significant progress has been made in our basic understanding of these processes using the mouse model, where implantation is ovarian estrogen-dependent in the presence of progesterone. However, an animal model where implantation is progesterone-dependent must also be studied to gain a full understanding of the embryo and uterine events that are required for implantation. In this regard, the hamster is a useful model and this review summarizes the information currently available regarding mechanisms involved in synchronous preimplantation embryo and uterine development for implantation in this species.

show abstract

Section: Hamsters As Preferred Models For Implantation Studiesmentioning

confidence: 99%

The hamster as a model for embryo implantation: Insights into a multifaceted process

Reese

Wang

Ding

et al. 2008

Seminars in Cell & Developmental Biology

View full text Add to dashboard Cite

show abstract

“…Spontaneous ovulation is reported to occur as early as 28 days of age in the golden hamster (Selle, 1945). Copulatory behavior and a postovulatory discharge were checked every day beginning at 27 days of age.…”

Section: Detection Of the First Ovulationmentioning

confidence: 99%

Postnatal development of the ovarian bursa of the golden hamster (Mesocricetus auratus): Its complete closure and morphogenesis of lymphatic stomata

1987

View full text Add to dashboard Cite

The golden hamster ovarian bursa was studied by light and electron microscopy to clarify the process of its complete closure and the development of lymphatics that leads to morphogenesis of stomata. The results were as follows. 1) The bursa completely closed at 9 days of age primarily due to development of the mesotubarium superius. 2) With the closure, the ovary and bursa became closely apposed, and most of the original bursal cavity disappeared. 3) Between 9 and 12 days of age U-shaped folds of the bursal mesothelium began to invade the connective tissue of the bursa. 4) Widening of the internal angle of the U-shaped folds contributed to reappearance of the bursal cavity, and thus separation of the bursa from the ovary. It also contributed to future geometrical proximity of lymphatics to the cavity of the bursa. 5) The separation of the bursa from the ovary began as early as 12 days of age in the cephalic half of the bursa. It occurred remarkably late in the caudal half. Juxtaposition of the window portion of the bursa to the ovary remained in some adult animals. 6) Development of lymphatics in the cephalic half of the bursa was divided into two stages, before and after days 21-24 of life. In the first stage, lymphatics grew in the submesothelial connective tissue, and the framework of lymphatics was formed. In the second stage, lymphatics extended small branches to form the submesothelial plexus or lymphatic lacuna. 7) Intercellular junctions between contiguous lymphatic endothelial cells were mostly tight and desmosomelike. Open junctions were, if they occurred at all, rare. (8) A smooth-surfaced area lined with the lymphatic endothelium was found in the bursa on day 27 of life, before the initiation of ovulation. Valvelike stomal orifices were absent before the initiation of ovulation and extremely rare even after the first ovulation. They were commonly present in the bursae after the fourth ovulation, however. The process of complete closure of the ovarian bursa is very complex and may be related to the later development of the bursal mesothelium and lymphatics. Some liplike stomal orifices are of purely developmental origin. However, all valvelike stomal orifices are assumed to be formed as a result of damage to the bursal mesothelium, as well as to the submesothelial connective tissue and lymphatics, by repetition of ovulation. It is possible that liplike stomal orifices may be formed in the process of repairing the damage.

show abstract

“…Selle [6] bred one female at 28 days of age, which bore 5 young; another, bred at 31 days, had 9 young. Most investigators agree that the female begins to cycle and show corpora lutea at 28-36 days [7][8][9][10].…”

Section: Discussionmentioning

confidence: 99%

Ontogenetic Aspects of Sexual Dimorphism and the Primary Immune Response to Sheep Erythrocytes in Hamsters from Prepuberty through Senescence

Blazkovec¹,

Orsini²

1976

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Ontogeny of the primary response to sheep erythrocytes of age-matched groups of male and female hamsters was studied at various chronological ages ranging from prepuberty to senescence. Selected organs were likewise weighed upon sacrifice to obtain developmental patterns. Adrenal weights were higher in the male, and pituitary weights were higher in the female; for both organs typical dimorphism was demonstrable by 36 days. Spleen weight and index favored the female by 46 days. Immunological sex dimorphism first appeared in groups injected at 53 days and autopsied at 58 days and persisted through senescence. Sexual dimorphism of antibody-mediated immunity, previously shown to favor the female in both the primary and secondary immune responses, thus follows the dimorphism of total amount of splenic lymphoid tissue and occurs shortly after realization of sexual maturity in the male. These findings support our previous suggestion of the suppressive effect of androgens on the antibody-mediated immune responsiveness of the male hamster.

show abstract

Hamster Sexually Mature at Twenty-Eight Days of Age

Cited by 12 publications

References 0 publications

The hamster as a model for embryo implantation: Insights into a multifaceted process

The hamster as a model for embryo implantation: Insights into a multifaceted process

Postnatal development of the ovarian bursa of the golden hamster (Mesocricetus auratus): Its complete closure and morphogenesis of lymphatic stomata

Ontogenetic Aspects of Sexual Dimorphism and the Primary Immune Response to Sheep Erythrocytes in Hamsters from Prepuberty through Senescence

Contact Info

Product

Resources

About