Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes

D’Abadia, Patrícia Lima; Bailão, Elisa Flávia Luiz Cardoso; Júnior, R.S. Lino; Oliveira, Matheus Gabriel de; Silva, Vinicius B.; Oliveira, Leandra A. R. de; Conceição, Edemilson Cardoso da; Reis, Paulo Roberto de Melo; Borges, Leonardo Luiz; Gonçalves, Pablo José; Almeida, Luciane Madureira

doi:10.1590/0001-3765202020190107

Cited by 17 publications

(19 citation statements)

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“…After latex centrifugation is possible to obtain two different fractions: 1) the top white zone with the rubber particles; and 2) the serum layer containing large variety of proteins and luteoids compounds. According to previous study, the serum layer fraction stimulates the angiogenesis and extracellular matrix remodeling processes (D'Abadia et al, 2020) and was chosen to perform this study. The same fractionation method was employed in Hevea brasilensis latex to obtain the sample control for the total protein quantification analysis.…”

Section: Hancornia Speciosa Latex Fractionationmentioning

confidence: 99%

Hancornia speciosa serum latex fraction: a non-allergenic biomaterial

et al. 2023

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Plant-derived products can assist in the healing process of dermal wounds. It has been demonstrated that Hancornia speciosa latex present angiogenic, osteogenic, anti-inflammatory, and antioxidant activities. Then, it could contribute to the wound healing process. However, natural products in contact with skin may cause dermatitis. The objective of this work was to evaluate the allergic and irritant potential of H. speciosa serum fraction latex using in vitro assays. The obtained results showed that the H. speciosa serum fraction latex has a slightly irritant potential and is not cytotoxic neither allergenic for human cells. Moreover, we identified a remarkable low amount of proteins in this material in comparison to Hevea brasiliensis latex. This result could explain the non-allergenic potential of H. speciosa serum fraction latex because proteins present in latex are the main responsible for allergy. This biomaterial could be used as a non-allergenic source for development of new medicines.

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Section: Hancornia Speciosa Latex Fractionationmentioning

confidence: 99%

Hancornia speciosa serum latex fraction: a non-allergenic biomaterial

et al. 2023

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“…Mangabeira bark extract possesses antioxidant activity and inhibits acetylcholinesterase production, which suggests that it can be used in the treatment of Alzheimer's, a disease linked with oxidative stress, acetylcholine deficiency in the brain, and inflammatory processes (Penido et al 2017). The trunk latex possesses angiogenic (Almeida et al 2014;D'Abadia et al 2020), osteogenic (Floriano et al 2016;Neves et al 2016), antiinflammatory (Marinho et al 2011), andantioxidant (D'Abadia et al 2020) activities, which may help in wound healing.…”

Section: Hancornia Speciosa Gomes (Apocynaceae)mentioning

confidence: 99%

Food Composition Data: Edible Plants in Cerrado

et al. 2021

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181negative correlation between the in vitro potential of many molecules and their ADME/T (absorption, distribution, metabolism, excretion/toxicity) profile is generally noted (Gleeson et al. 2011). Synthetic compounds present a significantly lower number of chiral centers and are both smaller and present greater flexibility, which results in weaker, less specific activity (Feher and Schmidt 2003). In contrast, plantderived natural products present a diversity of bioactive compounds with differing chemical scaffolds (Atanasov et al. 2015). Plant-derived products possess properties, such as binding affinities for specific proteins, that are evolutionary optimized (Appendino et al. 2010;Hunter 2008). Such characteristics make plant-derived products more advantageous for conducting ADME/T tests (Atanasov et al. 2015). Another advantage in drug discovery using medicinal plants is the known good correlation between ethnopharmacological information (well documented) and the medical use of the plant. Around 80% of identified compounds present some ethnomedicinal use, whether identical or related to current usage of the active plant elements (Fabricant and Farnsworth 2001). Further, technological advances in systems biology, bioinformatics, plant specialized metabolism, and synthetic biology present opportunities through which the medicinal properties of plants are discovered, utilized, and expanded toward developing new herb-inspired medicines (Li and Weng 2017). Accordingly, plant-derived natural products still represent a valuable source for drug discovery, this, motivated by global public health challenges, such as COVID-19, HIV/AIDS, malaria, hypertension, diabetes, and cancer (Thomford et al. 2018). About a quarter of all Food and Drug Administration (FDA)-and/or European Medical Agency (EMA)-approved drugs are plant-derived (Patridge et al. 2016;Thomford et al. 2018).In this context, Brazil possesses various biomes with a great portion of the world's biodiversity and approximately 20% of the plants and microorganisms on the planet (Calixto 2000). Among these biomes, the Cerrado is a neotropical savanna with rich flora (Klink and Machado 2005). Over 13,127 highly endemic plant species have been recorded within this biome (Myers et al. 2000;Overbeck et al. 2015;Silva and Bates 2002;Silveira et al. 2016). Yet, in regard to environmental conservation, only 41% of the original Cerrado still remains as native vegetation (Soares-Filho et al. 2014). This reduction is due to anthropogenic activities, such as monoculture, pasture expansions, mineral extraction, and the growth of urban areas (Faleiro et al. 2013). Considering only agricultural activity between 2002 and 2009, an estimated loss of 92,712 km 2 of natural Cerrado area has occurred (Overbeck et al. 2015). Preservation policies in Brazil need improvement, yet only 7% of the Cerrado is under legal protection (Soares-Filho et al. 2014).Both the bio-prospecting potential of the Cerrado for medicinal species and knowledge concerning traditional medicines are disappear...

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“…Quando avaliado a atividade angiogênica do látex de H. speciosa usando membrana corioalantóide de pintinhos (CAM) notou-se que o látex estimulou os processos de angiogênese e remodelação da matriz extracelular, a análise química indicou a presença de ácidos clorogênicos como os principais compostos encontrados na amostra de látex (D'Abadia et al, 2020). Um ensaio in vitro com Alluim cepa L., cebola, a respeito de uma investigação do nível de citotoxicidade e genotoxicidade, o látex de H. speciosa não exerceu efeitos inibitórios e citotóxicos nas células meristemáticas de A. cepa (Ribeiro et al, 2016).…”

Section: Harconia Speciosa Gomesunclassified

Látex de plantas da família Apocynaceae: Uma revisão

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O látex vegetal é excretado pelo sistema de defesa da planta, em resposta a estresses. Em certos casos, o látex pode apresentar toxicidade, mas sua utilização é viável, pois seus componentes podem possuir atividades biológicas variadas, como: antibacteriana; antitumoral; antioxidante; antifúngica, anti-inflamatório; larvicida, dentre outras. Diferentes famílias botânicas produzem látex, uma das principais e mais abrangente é a Apocynaceae. Diante dessa abrangência, torna-se necessário a realização de estudos sobre a aplicabilidade do látex. Deste modo, o presente estudo teve como objetivo promover a busca por trabalhos científicos que descrevessem sobre o uso do látex das espécies: Calotropis procera (Aiton) W.T. Aiton; Cryptostegia grandiflora R. Br; Cryptostegia madagascariensis Bojer; Hancornia speciosa Gomes; Himatanthus drasticus Mart.; Allamanda blanchetti A. DC. por meio de uma revisão bibliográfica. Os trabalhos científicos foram selecionados sob critérios de exclusão e inclusão, nas bases de dados: “Periódicos CAPES”, “Science Direct”, “Scielo”, “PubMed”,”Google Scholar” e “SciFinder” sob um intervalo de tempo de 37 anos (1984-2021), sendo utilizados trabalhos nos idiomas: inglês e português. Os resultados apontam que o látex das espécies, podem atuar como: antimicrobiano, anti-helmíntico, antitumoral, anticâncer, anti-inflamatório, quimioterapêutico, larvicida, inseticida, dentre outras atividades. Conclui-se que, o látex vegetal é uma fonte promissora para a síntese de fármacos, repelentes, cosméticos, e pode estimular pesquisas que visem a extração consciente de recursos naturais.

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Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes

Cited by 17 publications

References 48 publications

Hancornia speciosa serum latex fraction: a non-allergenic biomaterial

Hancornia speciosa serum latex fraction: a non-allergenic biomaterial

Food Composition Data: Edible Plants in Cerrado

Látex de plantas da família Apocynaceae: Uma revisão

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