Hand and Foot Syndrome Associated with Capecitabine

Abstract

Having cancer impacts the patient both psychologically and physically. However, if cancer is accompanied with HFS, the patient’s condition gets even worse. Capecitabine is a prodrug approved to treat several types of cancer such as breast and colorectal cancer. It is associated with several adverse effects such as hand and foot syndrome (HFS) which mostly affects the palms and legs. The provoked mechanisms of HFS are not clear yet. They require further validation of HFS pathogenesis. Up to now, prevention and treatment of HFS are not clearly solidified. Evidence supports the use of celecoxib, urea-based creams, and vitamin E to reduce the severity and the incidence of HFS. This review aims to provide the gaps and ways to further clinical evaluations.

Topical interventions for preventing hand-foot syndrome resulting from antineoplastic therapy: A scoping review

“…The CTCAE ( 2 ) (version 5.0 of 2017) classifies HFS into three degrees of severity, in which Grade 1 represents minimal changes in the skin or dermatitis, without pain; Grade 2 indicates changes in the skin, with pain, limiting instrumental Activity of Daily Living (ADL); and Grade 3 indicates severe skin changes, with pain, limiting self-care and ADL. Two other scales were used by some studies, namely: World Health Organization scale (WHO HFS), which has four grades of HFS classification ( 74 ) and the Canadian National Cancer Institute Clinical Trials Group (CTG-NCIC) scale, which classifies HFS into three grades ( 75 ) .…”

Intervenções tópicas para prevenção de síndrome mão-pé decorrente de terapia antineoplásica: revisão de escopo

“…O CTCAE (2) (versão 5.0 de 2017) classifica a SMP em três graus de severidade, no qual o Grau 1 representa alterações mínimas na pele ou dermatite, sem dor; o Grau 2 aponta alterações na pele, com dor, limitando Atividade de Vida Diária (AVD) instrumental; e o Grau 3 indica alterações cutâneas graves, com dor, limitando o autocuidado e AVD. Outras duas escalas foram utilizadas por alguns estudos, a saber: escala da Organização Mundial da Saúde (WHO HFS), que possui quatro graus de classificação da SMP (74) e a escala do Grupo de Ensaios Clínicos do Instituto Nacional do Câncer do Canadá (CTG-NCIC), que classifica a SMP em três graus (75) .…”