Hand Dermatitis: A Focus on Allergic Contact Dermatitis to Biocides

Maier, Lisa E.; Lampel, Heather P.; Bhutani, Tina; Jacob, Sharon E.

doi:10.1016/j.det.2009.05.007

Cited by 36 publications

(24 citation statements)

References 102 publications

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“…Several human studies have demonstrated the presence of IgE antibodies specific for glutaraldehyde adducts in the serum of exposed workers with respiratory disease [1, 2]. Importantly, workplace exposure to glutaraldehyde is known to induce occupational asthma [2–4] and allergic contact dermatitis [5] suggesting the need for safer alternatives. OPA has shown superior antimycobactericidal activity as compared to glutaraldehyde [6], allowing for its use at lower concentrations.…”

Section: Introductionmentioning

confidence: 99%

Inhalation ofOrtho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice

et al. 2011

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Ortho-Phthalaldehyde (OPA) has been approved for high-level sterilization of heat-sensitive medical instruments and is increasingly being used as a replacement in the healthcare industry for glutaraldehyde, a known sensitizer. Numerous case reports have been published indicating workers and patients experiencing respiratory problems, anaphylaxis, skin reactivity, and systemic antibody production. Our laboratory previously demonstrated that OPA is a dermal sensitizer in mice. The goal of the present study was to determine if OPA is a respiratory sensitizer following inhalation exposure. Mice were exposed to OPA vapor and airway and lymph nodes were examined for cytokine gene expression and alterations in lymphocyte populations. Inhalation of OPA for 3 days resulted in a concentration-dependent increase in lymphocyte proliferation, mainly B lymphocytes, in the draining lymph nodes. A secondary challenge of mice with OPA resulted in a dramatic increase in the population of B lymphocytes expressing IgE. Expression of Th2 (IL-4, IL-5, and IL-13) and anti/proinflammatory (IL-10, TNFα, and IL-1β) cytokine genes was upregulated in the lymph nodes and the nasal mucosa. Mice exposed to the higher concentrations of OPA-produced OPA-specific IgG1 antibodies indicating systemic sensitization. These findings provide evidence that OPA has the potential to cause respiratory sensitization in mice.

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Section: Introductionmentioning

confidence: 99%

Inhalation ofOrtho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice

et al. 2011

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“…Sources ( including formaldehyde releasing preservatives ) [ 18,165,166,172,173 ] Allergen of the Year : N/A Degree of Relevance : High (in children as well) [ 18,166,182 ] Classic Presentation : Hand dermatitis [ 173 ] and eyelid dermatitis [ 182 ] , as well as other presentations related to the site of contact with the product containing the allergen. For example, in textile dermatitis, regions where clothing rubs against the skin, i.e.…”

Section: Formaldehydementioning

confidence: 99%

“…Approximately 20 % of cosmetics and personal care products in the United States contain a formaldehyde-releaser, with imidazolidinyl urea (7 %) being the most frequent [ 170 ] . Quaternium-15, however, is known to have the highest sensitization potential, possibly due to its large release of formaldehyde [ 173,181 ] . Importantly, other quaternium compounds have not been shown to cause contact allergy.…”

Section: -41 Formaldehyde Releasing Preservatives (Frps) [ 189 ]mentioning

confidence: 99%

“…Description : broad spectrum preservative with activity against bacteria, fungi, and mites [ 173 ] . Sources : often occupational exposures, but MSDS may not be reliable to list all ingredients [ 100,173 ] [ 216 ] ; The Information Network of Departments of Dermatology (IVDK) in Germany reported 16 positive patch tests in a group of 4,883 patients, with possible false negatives suggested [ 217 ] .…”

Section: Iodopropynyl Butylcarbamate (Ipbc) or Glycacilmentioning

confidence: 99%

“…Sources : often occupational exposures, but MSDS may not be reliable to list all ingredients [ 100,173 ] [ 216 ] ; The Information Network of Departments of Dermatology (IVDK) in Germany reported 16 positive patch tests in a group of 4,883 patients, with possible false negatives suggested [ 217 ] . The testing concentration of IPBC has now been increased by the NACDG from 0.1 to 0.2 % to reduce false negative results based on recommendations from the IVDK [ 173,218 ] Classic Presentation : related to site of exposure; it can be responsible for hand dermatitis [ 173 ] Potential Ectopic Dermatitis : unlikely Potential Generalized/Systemic Dermatitis : IPBC is not used in aerosolized products due to pulmonary toxicity observed in animal models [ 219 ] Co-reactivity/Cross-reactivity : Cross-reactivity with carbamates (see #79)…”

Section: Iodopropynyl Butylcarbamate (Ipbc) or Glycacilmentioning

confidence: 99%

See 2 more Smart Citations

Practical Patch Testing and Chemical Allergens in Contact Dermatitis

Jacob¹,

Herro²

2013

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The Hazards of Moist Toilet Paper

Gardner

Davis²,

Richardson³

et al. 2010

Arch Dermatol

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Background: Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), a common preservative in some brands of moist toilet paper (baby wipes and moist towelettes), has been reported to be a cause of allergic contact dermatitis. However, few cases have been reported in the United States. Observations: We report the cases of 4 adult patients with severe perianal and perineal allergic contact dermatitis seen at our institution during a 6-month period. With patch testing, we identified allergy to MCI/MI, and we determined that all 4 patients were using moist toilet paper. The dermatitis resolved after use of the moist toilet paper was discontinued. Conclusion: This study highlights that the MCI/MI in moist toilet paper can be a cause of perianal and perineal allergic contact dermatitis.

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Hand Dermatitis: A Focus on Allergic Contact Dermatitis to Biocides

Cited by 36 publications

References 102 publications

Inhalation ofOrtho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice

Inhalation ofOrtho-Phthalaldehyde Vapor Causes Respiratory Sensitization in Mice

Practical Patch Testing and Chemical Allergens in Contact Dermatitis

The Hazards of Moist Toilet Paper

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