Hand eczema in children. Clinical and epidemiological study of the population referred to a tertiary hospital

Salvador, José María Ortiz; Ferrer, Daniela Subiabre; Rabasco, Ana García; Esteve‐Martínez, Altea; Ninet, Violeta Zaragozá; Miquel, Víctor Alegre de

doi:10.1016/j.anpede.2017.07.007

Cited by 9 publications

(12 citation statements)

References 23 publications

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“…23 Methylisothiazolinone/ methylchloroisothiazolinone was positive in only two children, relevant in both and should also be avoided in patients who have a positive reaction to methylisothiazolinone. 23 Cobalt sensitization in children with or without HE was higher than in adults from the NACDG cohort 14 and in European cohorts of adults and children. 20,24 Differences in patch testing results may reflect regional differences of personal care product use and other exposures.…”

Section: Discussionmentioning

confidence: 88%

“…One study of 389 Spanish children, aged 0–16 years, who were patch tested between 1996 and 2016 found that the most frequent allergens were thimerosal, nickel and cobalt, although they were of fairly low relevance (0–44·5%) 23 . Methylisothiazolinone/methylchloroisothiazolinone was positive in only two children, relevant in both and should also be avoided in patients who have a positive reaction to methylisothiazolinone 23 . Cobalt sensitization in children with or without HE was higher than in adults from the NACDG cohort 14 and in European cohorts of adults and children 20,24 .…”

Section: Discussionmentioning

confidence: 99%

“…Few studies specifically examined patch test results in paediatric patients with HE. One study of 389 Spanish children, aged 0–16 years, who were patch tested between 1996 and 2016 found that the most frequent allergens were thimerosal, nickel and cobalt, although they were of fairly low relevance (0–44·5%) 23 . Methylisothiazolinone/methylchloroisothiazolinone was positive in only two children, relevant in both and should also be avoided in patients who have a positive reaction to methylisothiazolinone 23 .…”

Section: Discussionmentioning

confidence: 99%

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Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

et al. 2021

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Learning & Change and has consulted for Henkel. J.S.T. owns noncontrolling shares of stock in AstraZeneca, Cigna, Merck, Johnson & Johnson and Opko Health. He has consulted for Kao Brands and Monsanto (Bayer), is a member of the Cosmetic Ingredient Review Steering Committee, and has a nondependent child employed by Pfizer. E.M.W. has received an investigator-initiated grant from and served as a consultant for Wen by Chaz Dean. She has also served as a consultant for Noven Pharmaceuticals. D.S. receives royalties SummaryBackground Little is known about the aetiologies and relevant allergens in paediatric patients with hand eczema (HE). Objectives To characterize the aetiologies and determine the proportion of positive and currently relevant allergens in children/adolescents (age < 18 years) with HE referred for patch testing. Methods A retrospective analysis (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016) of North American Contact Dermatitis Group data was performed. Results Of 1634 paediatric patients, 237 (14Á5%) had involvement of the hands. Final physician diagnoses included allergic contact dermatitis (49Á4%), atopic dermatitis (37Á1%) and irritant contact dermatitis (16Á9%). In multivariable logistic regression models, employment was the only association with increased odds of any HE or primary HE. Children with HE vs. those without HE had similar proportions of positive patch tests (56Á1% vs. 61Á7%; v 2 -test, P = 0Á11). The five most common currently relevant allergens were nickel, methylisothiazolinone, propylene glycol, decyl glucoside and lanolin. In multivariable logistic regression models of the top 20 relevant allergens, HE was associated with significantly higher odds of currently relevant reactions to lanolin, quaternium-15, Compositae mix, thiuram mix, 2-mercaptobenzathiazole and colophony. The allergens with the highest mean significance-prevalence index number were methylisothiazolinone, carba mix, thiuram mix, nickel and methylchloroisothiazolinone/methylisothiazolinone.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

et al. 2021

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“…• Dermatitis atópica 1,10,11,[14][15][16][17][18][19][20] . Una historia de dermatitis atópica es el predictor más fuerte de ECM en niños y adultos.…”

Section: Factores De Riesgounclassified

“…Una historia de dermatitis atópica es el predictor más fuerte de ECM en niños y adultos. La dermatitis atópica es la causa más frecuente de EM en niños 20 . Un estudio de EM en la población general danesa mostró que las mutaciones de filagrina están asociadas con ECM en pacientes con dermatitis atópica 16 .…”

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Guía para el diagnóstico, el tratamiento y la prevención del eccema de manos

Salvador

Mendaza

Garcés

et al. 2020

Actas Dermo-Sifiliográficas

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Recibido el 7 de marzo de 2019; aceptado el 21 de abril de 2019 laboral en el momento adecuado resultan cruciales para un buen manejo de estos pacientes.En esta guía sobre el eccema crónico de manos analizamos el proceso diagnóstico, las medidas preventivas y los tratamientos, con especial énfasis en el papel del médico de atención primaria y de medicina del trabajo en los estados iniciales de su manejo.

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Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey

et al. 2023

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Background Chronic hand eczema (CHE) significantly impacts quality of life. Published literature on pediatric CHE (P-CHE) in North America including knowledge on epidemiology and standard evaluation and management is limited. Objective Our objective was to assess diagnostic practices when evaluating patients with P-CHE in the US and Canada, produce data on therapeutic agent prescribing practices for the disorder, and lay the foundation for future studies. Methods We surveyed pediatric dermatologists to collect data on clinician and patient population demographics, diagnostic methods, therapeutic agent selection, among other statistics. From June 2021 to January 2022, a survey was distributed to members of the Pediatric Dermatology Research Alliance (PeDRA). Results Fifty PeDRA members responded stating that they would be interested in participating, and 21 surveys were completed. For patients with P-CHE, providers most often utilize the diagnoses of irritant contact dermatitis, allergic contact dermatitis, dyshidrotic hand eczema, and atopic dermatitis. Contact allergy patch testing and bacterial hand culture are the most used tests for workup. Nearly all utilize topical corticosteroids as first line therapy. Most responders report that they have treated fewer than six patients with systemic agents and prefer dupilumab as first-line systemic therapy. Conclusions This is the first characterization of P-CHE among pediatric dermatologists in the United States and Canada. This assessment may prove useful in designing further investigations including prospective studies of P-CHE epidemiology, morphology, nomenclature, and management. Supplementary Information The online version contains supplementary material available at 10.1007/s40272-023-00574-x.

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Hand eczema in children. Clinical and epidemiological study of the population referred to a tertiary hospital

Cited by 9 publications

References 23 publications

Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

Hand eczema in children referred for patch testing: North American Contact Dermatitis Group Data, 2000–2016*

Guía para el diagnóstico, el tratamiento y la prevención del eccema de manos

Diagnosis and Management of Pediatric Chronic Hand Eczema: The PeDRA CACHES Survey

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