Hand–foot syndrome caused by docetaxel with no recurrence after switch to paclitaxel, a different taxane

Abstract

A case of Hand-foot syndrome caused by docetaxel with no recurrence after switch to paclitaxel, a different taxane is described

Dermatological adverse events with taxane chemotherapy

“…The development of a HFS is relatively more common with docetaxel [11, 75–80], as opposed to paclitaxel [6, 13, 81, 82]. While less frequent than with other chemotherapeutic agents, such as fluorouracil, capecitabine, and doxorubicin [83], it occurs in 5–10% of patients treated with taxanes [6, 41, 78].…”

“…Scaly erythematous lesions are seen predominantly on the dorsal aspects of hands (overlying the joints) and thenar eminences (figures 6 A–B) [11, 13, 75–77, 81, 85], and more rarely on the dorsum of the feet (figure 6C) or the peri-malleolar and Achilles regions [75, 82]. The dorsal hand eruption typically does not cross the Wallace’s line, a transitional zone that runs along the medial and lateral borders of the hands.…”

“…The dorsal hand eruption typically does not cross the Wallace’s line, a transitional zone that runs along the medial and lateral borders of the hands. Occasionally, palmoplantar involvement may be noted [75, 77, 82]. The constellation of PeriArticular Thenar Erythema and Onycholysis characterize the “PATEO syndrome” seen in patients on docetaxel (figure 6D) [41]; not all nails are universally affected, although their involvement is common [75].…”

“…Occasionally, palmoplantar involvement may be noted [75, 77, 82]. The constellation of PeriArticular Thenar Erythema and Onycholysis characterize the “PATEO syndrome” seen in patients on docetaxel (figure 6D) [41]; not all nails are universally affected, although their involvement is common [75]. The lesions may start from the first treatment cycle or develop progressively during subsequent cycles [75], and may sometimes be heralded by prodromal symptoms such as tingling, burning pain, or numbness.…”

“…The constellation of PeriArticular Thenar Erythema and Onycholysis characterize the “PATEO syndrome” seen in patients on docetaxel (figure 6D) [41]; not all nails are universally affected, although their involvement is common [75]. The lesions may start from the first treatment cycle or develop progressively during subsequent cycles [75], and may sometimes be heralded by prodromal symptoms such as tingling, burning pain, or numbness. The dorsal HFS is bilateral, but not necessarily strictly symmetric, and pruritus, pain, or a burning sensation are generally the most prominent symptoms.…”