Hand-foot syndrome due to capecitabine

Surjushe, Amar; Vasani, Resham; Medhekar, Sudhir; Thakre, Minal; Saple, D. G.

doi:10.4103/0019-5154.39747

Cited by 13 publications

(13 citation statements)

References 4 publications

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“…However, hyperpigmentation of hands and feet, rather than erythema are found to be the initial manifestation in most patients and are considered by many authors as Grade 1 HFS. [ 5 6 ]…”

Section: Discussionmentioning

confidence: 99%

An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?

Vasudevan

2010

Indian J Pharmacol

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A 59-year-old man with adenocarcinoma of stomach was prescribed capecitabine as adjuvant chemotherapy. After two cycles of therapy, patient developed hyperpigmentation on hands and feet. Examination revealed a peculiar distribution of hyperpigmentation on hands and feet and in addition, hyperpigmented spots on the dorsum of tongue. Although hand-foot syndrome (HFS) to capecitabine solely manifesting as palmoplantar hyperpigmentation has been described earlier, this is probably the first instance wherein oral pigmentation has also been found in association. In addition, this finding lends support to the growing argument of hyperpigmentation being a separate entity: different from HFS, both therefore being separate adverse effects of the same drug.

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“…However, hyperpigmentation of hands and feet, rather than erythema are found to be the initial manifestation in most patients and are considered by many authors as Grade 1 HFS. [ 5 6 ]…”

Section: Discussionmentioning

confidence: 99%

An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?

Vasudevan

2010

Indian J Pharmacol

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“…A SMP, também conhecida como eritrodisestesia palmo-plantar ou eritema acral, é uma reação adversa decorrente da terapia com agentes quimioterápicos e biológicos (3) que foi primeiramente descrita em associação com o mitotano por Zuehlke em 1974 (2) . Nos casos leves a moderados, podem ocorrer eritema doloroso e edema, vários graus de disestesia, que podem ser seguidos por descamação úmida ou seca das palmas das mãos e solas dos pés.…”

Section: Introductionunclassified

“…Nos casos leves a moderados, podem ocorrer eritema doloroso e edema, vários graus de disestesia, que podem ser seguidos por descamação úmida ou seca das palmas das mãos e solas dos pés. Já em casos mais graves ocorrem: rachaduras, descamações da pele, bolhas, úlceras e dores intensas que podem interferir nas atividades diárias (3) .…”

Section: Introductionunclassified

Síndrome Mão-Pé Induzida Por Capecitabina: Relato De Caso

et al. 2017

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RESUMO: A capecitabina é um agente quimioterápico indicado, dentre outros casos, como monoterapia no câncer de mama metastático. A síndrome mão-pé consiste numa das reações adversas associadas ao seu uso e caracteriza-se por eritema doloroso, edema, disestesia, descamação, bolhas e úlceras nas regiões palmar e plantar. Objetivou-se descrever o caso de uma paciente portadora de carcinoma de mama esquerda com metástase hepática que apresentou síndrome mão-pé decorrente do tratamento com capecitabina. Trata-se de um relato de caso ocorrido num hospital universitário de um estado do nordeste do Brasil em 2016. Foi necessária a suspensão do protocolo antineoplásico utilizado. Observou-se remissão parcial dos sintomas após o uso do gel de Aloe vera para o tratamento das áreas afetadas. Ressalta-se a importância do relato para conhecimento dessa reação adversa, facilitando sua identificação e manejo, para promover melhora da qualidade de vida do paciente oncológico. DESCRITORES: Síndrome mão-pé; Antineoplásicos; Neoplasias da mama. CAPECITABINE-INDUCED HAND-FOOT SYNDROME: A CASE REPORTABSTRACT: Capecitabine is a chemotherapeutic agent indicated, among other things, as monotherapy for metastatic breast cancer. Hand-foot syndrome is one of the adverse effects associated with its use and is characterized by painful erythema, edema, dysesthesia, desquamation, blistering and ulcers in the palms and soles. This study presents a case report on a patient with left-sided breast cancer metastasized to the liver, who suffered from capecitabine-induced hand-foot syndrome. The patient was being treated at a university hospital in a state in the Northeast of Brazil in 2016. Her antineoplastic protocol had to be suspended. After the use of Aloe vera gel to treat the affected areas, there was a partial remission of symptoms.It is important to expand knowledge about this adverse reaction, facilitating its identification and management, in order to improve quality of life in cancer patients. DESCRIPTORS: Hand-foot Syndrome; Antineoplastic Agents; Breast Neoplasms. Cogitare Enferm. 2017 Jan/mar; 22(1): 01-04 SÍNDROME MANO-PIE INDUCIDO POR CAPECITABINA: RELATO DE CASO RESUMEN: La capecitabina es un agente quimioterápico indicado, entre otros casos, como monoterapia en cáncer de mama metastático. El síndrome mano-pie consiste en una de las reacciones adversas asociadas a su uso, caracterizada por eritema doloroso, edema, parestesia, descamación, ampollas y úlceras en regiones palmar y plantar. Se objetivó describir el caso de una paciente con carcinoma en mama izquierda, con metástasis hepática presentando síndrome de mano-pie derivado del tratamiento con capecitabina. Relato de caso ocurrido en hospital universitario de estado del Noreste brasileño en 2016. Fue necesaria la suspensión del protocolo antineoplásico utilizado. Se observó remisión parcial de los síntomas luego de uso de gel de Aloe Vera para tratamiento de las áreas afectadas. Se destaca la importancia del relato para conocimiento de esta reacción adversa, permitiendo su ide...

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“…A common, dose-limiting, adverse effect of capecitabine is hand and foot syndrome (HFS), a condition that can be classified into three grades according to the intensity of the symptoms: Grade 1: Dysesthesia or paresthesia, erythema and swelling; Grade 2: Pain and discomfort affect the daily activities; Grade 3: Blistering, moist ulceration and desquamation, and severe pain. However, palmoplantar hyperpigmentation has been suggested by many authors to be included in Grade 1 HFS, since it has been found as the initial manifestation in most patients rather than erythema, besides camouflaging classical signs and symptoms of HFS [2][3][4] .…”

Section: Introductionmentioning

confidence: 99%

Oral hyperpigmentation as adverse effect to capecitabine

Silva¹,

Chicrala²,

Soares-Junior³

et al. 2017

J Oral Diag

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Capecitabine (Xeloda ®) is an antineoplastic drug normally used as adjuvant chemotherapy for metastatic colorectal and breast cancer. A common adverse effect of capecitabine is hand and foot syndrome (HFS), a condition that, although not life threatening, can reduce drastically quality of life and result in patient withdrawal from treatment. Palmoplantar hyperpigmentation is a condition that has been found as the initial manifestation of HFS in most patients. The association of palmoplantar and oral hyperpigmentation as an adverse effect to capecitabine has rarely been described in the literature. We report a case of oral and palmoplantar hyperpigmentation in a 61-year-old woman receiving capecitabine for metastatic colon cancer. At the chemotherapy 2 nd cycle, the patient referred burning mouth, and clinical inspection revealed brownish spots measuring between 2 and 10 mm, in addition to similar hyperpigmentated macules in palms and soles of feet, both asymptomatic. A 7-month-follow-up, still under chemotherapy with oral Xeloda ® , showed regression of mouth manifestations while the palmoplantar spots intensified, with progression of dryness and tingling. This report highlights the importance of early diagnosis of HFS through the oral hyperpigmentation, which is a manifestation easily detectable by the dentist.

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Hand-foot syndrome due to capecitabine

Cited by 13 publications

References 4 publications

An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?

An unusual case of capecitabine hyperpigmentation: Is hyperpigmentation a part of hand-foot syndrome or a separate entity?

Síndrome Mão-Pé Induzida Por Capecitabina: Relato De Caso

Oral hyperpigmentation as adverse effect to capecitabine

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