Hand Function after High Dose Rate Brachytherapy for Squamous Cell Carcinoma of the Skin of the Hand

Somanchi, Brinda Vihari; Stanton, A.W.B.; Webb, Mark; Loncaster, Juliette A; Allan, Ernest; Muir, Lindsay

doi:10.1016/j.clon.2008.06.008

Cited by 39 publications

(46 citation statements)

References 23 publications

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“…Late reactions were noted in two thirds of patients but were of mild intensity. No deformations, restriction of hand movements or loss of sensitivity were observed during followup [13].…”

Section: Discussionmentioning

confidence: 83%

“…Plesiotherapy involves the use of surface applicators in direct contact with the tumour or surgical tumour bed. This radiation technique achieves tumoral control rates similar to external radiotherapy but shortens the overall treatment time [9][10][11][12][13]. Therefore, plesiotherapy appears to be an ideal alternative for elderly patients with small and superfi cial tumours not candidates for aggressive surgical management.…”

Section: Introductionmentioning

confidence: 95%

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High-dose-rate (HDR) plesiotherapy with custom-made moulds for the treatment of non-melanoma skin cancer

et al. 2009

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“…Late reactions were noted in two thirds of patients but were of mild intensity. No deformations, restriction of hand movements or loss of sensitivity were observed during followup [13].…”

Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 95%

High-dose-rate (HDR) plesiotherapy with custom-made moulds for the treatment of non-melanoma skin cancer

et al. 2009

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“…The differences across the two groups were not statistically significant. 6 As with previously discussed studies, these studies suggest that HDR brachytherapy can induce prolonged remission with few peripheral tissue effects in relatively small, well-demarcated NMSC; long-term cure was not shown, and objective or unbiased measures of postoperative cosmesis remain lacking. Surface-mold brachytherapy has also been used for multiple, recurrent tumors with vast and irregular surface areas.…”

Section: Surface-mold Brachytherapymentioning

confidence: 83%

“…In addition, ionizing radiation can penetrate deeply, potentially injuring adjacent tissue and organs causing brain and bone necrosis. 6,7 Skin changes associated with radiation, such as atrophy, telangiectasia, and pigmentation, may worsen with time.…”

Section: Treatment Of Nmsc With Radiotherapymentioning

confidence: 99%

“…Objective measures included the presence of late radiation effects such as alopecia, telangiectasia, skin atrophy, pigmentation disorders, and scarring. 1,6,30 Functional measures such as pain, 30 or range of motion of joints, 6 were also evaluated. Overall, cosmetic and functional results were good, with better results observed for smaller tumors.…”

Section: Surface-mold Brachytherapymentioning

confidence: 99%

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The use of brachytherapy in the treatment of nonmelanoma skin cancer: A review

Alam

Nanda

Mittal

et al. 2011

Journal of the American Academy of Dermatology

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Surgical excision, Mohs micrographic surgery, external‐beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta‐analysis of 58 studies with 21,000 patients

Lee

Lehrer

Aphale

et al. 2019

Cancer

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BACKGROUND:The objective of this study was to compare the cosmesis and recurrence rates of conventional excision (CE), Mohs micrographic surgery (MMS), external-beam radiation therapy (EBRT), or brachytherapy (BT), for basal cell carcinoma and squamous cell carcinoma of the skin. METHODS: Population, Intervention, Control, Outcome, Study Design (PICOS), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and Meta-Analyses of Observational Studies in Epidemiology (MOOSE) methods were used to identify studies on PubMed (from 1985 to 2018), including patients with American Joint Committee on Cancer (AJCC) T1-T2N0 basal cell carcinomas and squamous cell carcinomas and ≥10 months follow-up who received CE, MMS, EBRT, or BT. The primary endpoint was cosmesis, classified as "good," "fair," or "poor." The secondary endpoint was 1-year recurrence. Fixed-effects and random-effects meta-analyses were performed to evaluate primary and secondary outcomes with respect to treatment modality. RESULTS: In total, 18,095 studies met initial search criteria. There were 24 CE, 13 MMS, 19 EBRT, and 7 BT studies included with a total of 21,371 patients. The summary effect size for "good" cosmesis was 81% (95% CI, 70.6%-89.6%), 74.6% (95% CI, 63%-84.6%), and 97.6% (95% CI, 91.3%-100%) for CE, EBRT, and BT, respectively. Good cosmesis was 96.0% in the only MMS study that reported cosmesis. BT had improved "good" cosmesis over EBRT (P = .0025) and was similar to CE and MMS. No significant differences were seen for "fair" or "poor" cosmesis. One-year recurrence rates were low throughout at 0.8% (95% CI, 0.3%-1.6%), 0.2% (95% CI, 0%-0.6%), 2% (95% CI, 1.3%-2.7%), and 0% (95% CI, 0%-0.5%) for CE, MMS, EBRT, and BT, respectively. CONCLUSIONS: For T1-T2N0 skin cancers, BT and MMS have improved cosmesis over EBRT and CE. It is unclear whether this is because of treatment superiority or selection and reporting bias. Local control is similar among all modalities at 1 year. Cancer 2019;125:3582-3594.

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Hand Function after High Dose Rate Brachytherapy for Squamous Cell Carcinoma of the Skin of the Hand

Cited by 39 publications

References 23 publications

High-dose-rate (HDR) plesiotherapy with custom-made moulds for the treatment of non-melanoma skin cancer

High-dose-rate (HDR) plesiotherapy with custom-made moulds for the treatment of non-melanoma skin cancer

The use of brachytherapy in the treatment of nonmelanoma skin cancer: A review

Surgical excision, Mohs micrographic surgery, external‐beam radiotherapy, or brachytherapy for indolent skin cancer: An international meta‐analysis of 58 studies with 21,000 patients

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