Smart wearable sensors in human–machine interfaces (HMI) facilitate communication and interface between humans and robots, as well as among humans. Conventional wearables face significant limitations, including performance degradation under various deformations (e.g., strain and pressure), limited stretchability and flexibility, poor comfort, and breathability, complicating their integration into HMI applications. In response to these limitations, a smart, sewable, high‐precision HMI device based on a soft, textile‐based sensor with machine learning (ML)‐assisted data processing is proposed. The (Ag)‐based fabric electrode integrated into polymeric composite dielectric layer, exhibiting hysteresis error of (≤4%), a tensile strain sensitivity of gauge factor (GF) ≃ 1.03 at 100% elongation, a pressure sensitivity of ≈1.583 × 10−2 kPa−1 at pressures (<50 kPa) and excellent stability (>1000 cycles). To demonstrate its versatility in HMI, the textile‐based sensor is integrated into a glove for real‐time control of a commercially available prosthetic hand and a drone, as well as for sign language recognition, achieving 95.4% classification accuracy using the random forest (RF) classifier across 10 gestures. Beyond gesture recognition, the sensor measures a range of subtle physiological activities (>0.35 kPa), functioning as a force myograph, esophageal manometry, and in gait analysis, among other strain and pressure‐related applications, highlighting exceptional capabilities for advanced wearable systems.