Hand grip strength as a predictor of postoperative complications in esophageal cancer patients undergoing esophagectomy

Sato, Shinsuke; Nagai, Eishi; Taki, Yusuke; Watanabe, Masaya; Watanabe, Yuki; Nakano, Kiyokaze; Yamada, Hiroyuki; Chiba, Takuya; Ishii, Yuichiro; Ogiso, Hiroshi; Takagi, Masakazu

doi:10.1007/s10388-017-0587-3

Cited by 45 publications

(19 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…36 In oesophageal cancer, low HGS had high predictive value for morbidity and surgical mortality. 37 Consistent with our study, Kilgour et al 38 reported a shorter survival for patients whose HGS values were within the lowest 10th percentile of HGS values in advanced non-small lung cancer and gastrointestinal cancer. However, they did not show concrete cut-off points and enough information such as nutritional indices or Figure 2 Handgrip strength in different cancer types stratified by sex.…”

Section: Discussionsupporting

confidence: 91%

See 1 more Smart Citation

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Zhuang

Zhang

et al. 2020

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background Handgrip strength (HGS) is associated with poor clinical outcomes, including all-cause, non-cardiovascular, and cardiovascular mortalities. The published cutoff points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex-specific cutoff points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality. Methods We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer-specific mortality was calculated using Cox proportional hazard regression models. Results Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cutoff points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [

show abstract

Section: Discussionsupporting

confidence: 91%

“…HGS was an excellent predictor of functional decline in patients with breast cancer 36 . In oesophageal cancer, low HGS had high predictive value for morbidity and surgical mortality 37 . Consistent with our study, Kilgour et al 38 .…”

Section: Discussionsupporting

confidence: 87%

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Zhuang

Zhang

et al. 2020

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

show abstract

“…Grip strength can reflect overall muscle strength in the human body. Low grip strength recovery related to a reduced physical activity, a decline in respiratory muscle strength [30], an increased risk of falls, an increased occurrence of complications and readmission [31, 32]. Moreover, the extension of the inflammatory reparation process after cardiac surgery may also result in decreasing grip strength and therefore decreasing postoperative physical function [14].…”

Section: Discussionmentioning

confidence: 99%

Perioperative poor grip strength recovery is associated with 30-day complication rate after cardiac surgery discharge in middle-aged and older adults - a prospective observational study

Zhang

Shao

et al. 2019

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundAlthough perioperative care during heart surgery has improved considerably, the rate of postoperative complications has remained stable. It has not been concluded how to better apply grip strength to clinical, postoperative complications. So our study aimed at researching the best way for using grip value for predicting early postoperative complications.MethodsA total of 212 patients with mean age 63.8 ± 6.3 who underwent cardiac surgery participated in our study. We analyzed the ROC curve of grip strength, grip/weight and grip recovery with complications, found the best cutoff point. Logistic regression confirmed the association between grip strength grouping and complications.ResultsWe found that 36 patients had 30-day complications. EuroSCORE were 2.15 ± 1.52 and 2.42 ± 1.58 between normal and complication groups, respectively. The area under the receiver-operating characteristic curve (AUC) of grip recovery take the most area (0.837, p < 0.001), and the cutoff point was 83.92%. In logistic regression, lower grip recovery has higher risk impact on 30-day complications for 25.68 times than normal group, after adjusted surgery-related factors. After regrouped characteristic information by grip recovery cutoff point, we found that percentage of the estimated 6 min walk distance (41.5 vs 48.3, p = 0.028) and hospitalization time (7.2 vs 6.1, p = 0.042) had worse trends in lower recovery group.ConclusionsPoor grip recovery may be related to higher risk of postoperative complications within 30 days after discharge in middle-aged and older people independent of surgical risk. The results of this study provide a reference for the development of rehabilitation programs in the early postoperative recovery, and may also be a prognostic indicator for postoperative high-risk groups.Trial registrationOur research was registered on Research Registry website, the registry number was ChiCTR1800018465. Date: 2018/9/20. Status: Successful.

show abstract

“…In people with cancer, reduced muscle mass and strength are also negatively associated with disease‐free survival and overall survival . Tumour growth is known to promote loss of muscle mass and function; however, the specific mechanisms mediating this effect are incompletely understood .…”

Section: Introductionmentioning

confidence: 99%

Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Narsale

Moya

et al. 2019

J cachexia sarcopenia muscle

View full text Add to dashboard Cite

Background Tumour growth can promote the loss of muscle mass and function. This is particularly disturbing because overall survival is significantly reduced in people with weaker and smaller skeletal muscle. The risk of cancer is also greater in people who are immune deficient. Muscle wasting in mice with cancer can be inhibited by infusion of CD4 + precursor T cells that restore balanced ratios of naïve, memory, and regulatory T cells. These data are consistent with the hypothesis that stronger anti‐cancer T cell immunity leads to improved muscle mass and function. As a first step to testing this hypothesis, we determined whether levels of circulating T cell subsets correlate with levels of muscle strength in people with cancer. Methods The frequency of circulating CD4 + and CD8 + naïve, memory, and regulatory T cell subsets was quantified in 11 men with gastrointestinal cancer (aged 59.3 ± 10.1 years) and nine men without cancer (aged 60 ± 13 years), using flow cytometry. T cell marker expression was determined using real‐time PCR and western blot analyses in whole blood and peripheral blood mononuclear cells. Handgrip strength, one‐repetition maximum chest press, and knee extension tests were used to determine muscle strength. Performance was determined using a stair climb test. Body composition was determined using dual‐energy X‐ray absorptiometry scan. The Karnofsky and ECOG scales were used to assess functional impairment. Correlations between frequencies of cell subsets with strength, performance, and body composition were determined using regression analyses. Results Our data show significant correlations between (i) higher frequencies of CD8 + naïve ( P = 0.02) and effector memory ( P = 0.003) T cells and lower frequencies of CD8 + central memory T cells ( P = 0.002) with stronger handgrip strength, (ii) lower frequency of regulatory cells with greater lean mass index ( P = 0.04), (iii) lower frequency of CD8 + T cells that express CD95 with greater stair climb power ( P = 0.003), (iv) higher frequency of T cells that co‐express CD197 and CD45RA and greater one‐repetition maximum knee extension strength ( P = 0.008), and (iv) higher expression of CD4 in whole blood with greater functional impairment ( P = 0.004) in people with cancer. Conclusions We have identified significant correlations between levels of T cell populations and muscle strength, performance, and body composition in people with cancer. These data justify a follow‐up study with a larger cohort to test the validity of the findings.

show abstract

Hand grip strength as a predictor of postoperative complications in esophageal cancer patients undergoing esophagectomy

Abstract: Preoperative HGS is an independent predictive factor of postoperative complications, especially postoperative pneumonia, for elderly male patients with esophageal cancer treated with radical esophagectomy.

Cited by 45 publications

References 32 publications

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Associations of low handgrip strength with cancer mortality: a multicentre observational study

Perioperative poor grip strength recovery is associated with 30-day complication rate after cardiac surgery discharge in middle-aged and older adults - a prospective observational study

Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study

Contact Info

Product

Resources

About