As one of the most perilous industries, agriculture presents both fatal and non-fatal risks to farmers. Pakistan, a notable Asian nation, heavily depends on agriculture, which constitutes 23% of its GDP and employs 37.4% of its workforce. The study investigates the challenges within Pakistan’s agriculture sector and enriches the existing literature by gathering data on agricultural machine-related injuries in Pakistan during 2022–2023. The survey, conducted from November 2022 to April 2023, involved 55 respondents, predominantly from Sindh and Punjab. The findings indicate a total of 507 injuries, with approximately a quarter being fatal (121 incidents). Sindh emerges as a significant hotspot, with the majority of injuries documented there. With respect to the key sources of injuries, the fodder cutter is a primary source of injuries with 201 injuries documented, accounting for approximately 40% of all injuries. Threshers contributed to 197 injuries, approximately 39% of the total, and about 52 are tractor-related injuries, making up about 10% of machine injuries. Regarding the severity and demographics of injuries, about 38% of cases involve amputation, with a higher incidence among males (77%) and individuals aged 15–34 years (65%). It is important to acknowledge the study’s limitations, including a small participant pool and a brief data collection period. This research advocates for safety regulations, accident reduction measures, and increased safety awareness among farmers, aiming to foster a safer and more sustainable agricultural environment in Pakistan.