Hand Muscle Atrophy in Multiple Sclerosis

Fisher, Marc; Long, Randall R.; Drachman, David A.

doi:10.1001/archneur.1983.04050120061009

Cited by 22 publications

(6 citation statements)

References 13 publications

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“…We do not observe such a striking size-related susceptibility to neuronal injury, with similar proportions of interneurons and motoneurons being lost. Focal muscular atrophy is a relatively uncommon but well recognized feature of MS, estimated to occur in 6%-7% of patients (13,22). Given the magnitude of the anterior horn cell loss that we observed, it is perhaps surprising that we do not observe the classical signs of lower motoneuron pathology in the clinical setting more frequently.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Neuronal Pathology in Multiple Sclerosis

Gilmore¹,

DeLuca²,

Liu³

et al. 2009

Brain Pathology

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The objective of this study was to assess neuronal pathology in the spinal cord in multiple sclerosis (MS), both within myelinated and demyelinated tissue. Autopsy material was obtained from 38 MS cases and 21 controls. Transverse sections were taken from three spinal cord levels and stained using Luxol Fast Blue/Cresyl Violet and myelin protein immunohistochemistry. Measurements of neuronal number and size were made for all neurons within the anterior horns of the gray matter. Neurons were classified as motoneurons or interneurons according to size criteria. In comparison with controls, both motoneuron and interneuron number were reduced in MS cases at the upper cervical (interneuron P = 0.0549; motoneuron P = 0.0073) and upper thoracic (interneuron P = 0.0507; motoneuron P = 0.0144), but not the lumbar level. Interneuron cross-sectional area was reduced in MS cases at all levels (upper cervical, P = 0.0000; upper thoracic, P = 0.0002; lumbar, P = 0.0337). Neuronal loss appears to be predominantly related to local gray matter plaques, whereas interneuron atrophy occurs in both myelinated and demyelinated areas.

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Section: Discussionmentioning

confidence: 99%

Spinal Cord Neuronal Pathology in Multiple Sclerosis

Gilmore¹,

DeLuca²,

Liu³

et al. 2009

Brain Pathology

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“…[2][3][4][5] The concurrence of these two disorders is, thus, clearly rare, of the order of 3 per 10 billion individuals. Although the development of lower motor neuron signs is well documented in MS, 6,7 complete descriptions of these concurrences of two disorders are quite rare. Indeed, only two autopsy cases are well described in the modern literature.…”

Section: Introductionmentioning

confidence: 99%

Amyotrophic lateral sclerosis with multiple sclerosis: A clinical and pathological report

Dynes

Schwimer

Staugaitis

et al. 2000

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

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We report a 62-year-old woman with a past history of painful central visual loss who developed progressive quadriparesis and bulbar palsy. Neurological examination revealed widespread upper and lower motor neuron signs in the bulbar region and extremities. Electromyography demonstrated widespread active and chronic motor axon loss. Magnetic resonance neuroimaging studies revealed enhancing callosal and periventricular white matter lesions and cervical and thoracic cord hyperintensities. Cerebrospinal fluid analysis was consistent with multiple sclerosis. The patient died of respiratory failure two years after presentation, and autopsy revealed multifocal demyelination involving the corpus callosum, cerebellum and spinal cord as well as pathologic findings typical of amyotrophic lateral sclerosis. A review of the literature confirms the exceedingly unusual combination of amyotrophic lateral sclerosis with multiple sclerosis.

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“…However, in 6–7% of MS patients, focal muscular atrophy is reported 23 24. As electrophysiological diagnostic revealed no signs of peripheral nerve system involvement, atrophies were ascribed to inactivity resulting from diminished use of the affected hand.…”

Section: Discussionmentioning

confidence: 99%

Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: coincidence or causal relationship?

Borisow¹,

Meyer

Paul

2013

BMJ Case Reports

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We report a 55-year-old patient, presenting with paresis, muscle atrophy and dysarthria, all symptoms accordable to definite amyotrophic lateral sclerosis (ALS). However, MRI and cerebrospinal fluid show abnormalities typical of multiple sclerosis (MS). On the basis of this case report, we discuss possible overlaps between both diseases by comparing clinical and paraclinical features including laboratory, radiological and electrophysiological diagnostics. As genetic, as well as environmental, factors are assumed to be involved in the development of both the diseases, literature is reviewed according to similar cases, results of autopsies and possible parallels in pathogenesis. In summary, based on the data currently available, the hypothesis of ALS being a neurodegenerative multisystem disorder, a common pathophysiological pathway or, alternatively, a random comorbidity of ALS and MS in this patient has to be discussed.

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Hand Muscle Atrophy in Multiple Sclerosis

Cited by 22 publications

References 13 publications

Spinal Cord Neuronal Pathology in Multiple Sclerosis

Spinal Cord Neuronal Pathology in Multiple Sclerosis

Amyotrophic lateral sclerosis with multiple sclerosis: A clinical and pathological report

Concomitant amyotrophic lateral sclerosis and paraclinical laboratory features of multiple sclerosis: coincidence or causal relationship?

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