Handbook of Psoriasis and Psoriatic Arthritis

Warren, Richard B.; Menter, Alan

doi:10.1007/978-3-319-18227-8

Cited by 5 publications

References 57 publications

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Impact of moderate-to-severe psoriasis on quality of life in China: a qualitative study

Zhong

Yang

Mao

et al. 2021

Health Qual Life Outcomes

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Purpose Psoriasis is a serious health problem. Since limited research has investigated the impact of psoriasis on the quality of life of patients with moderate-to-severe psoriasis, this study aimed to explore this issue. Methods A qualitative study was conducted with 22 psoriasis patients from two cities in Shandong province of eastern China participating in one-to-one semi-structured in-depth interviews. Results Thematic analysis generated five major themes: (1) Symptoms, symptoms management and pain; (2) Functioning and activities of daily living (ADLs); (3) Psychological impact; (4) Social impact; (5) Employment and finances. Conclusion Our study detailed the effects of psoriasis on patients’ symptoms, symptoms management and pain, functioning and activities of daily living (ADLs), psychological impact, social impact, employment and finances. These data can provide a reference for studying the quality of life in patients with psoriasis.

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Impact of moderate-to-severe psoriasis on quality of life in China: a qualitative study

Zhong

Yang

Mao

et al. 2021

Health Qual Life Outcomes

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Evaluation of Serum Level of Sclerostin in Patients with Psoriatic Arthritis

Sorour

Hafeez

Akl

et al. 2021

Benha Journal of Applied Sciences

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Background: Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovascular disease. The aim of the work is to evaluate serum level of sclerostin in patients with psoriatic arthritis and to correlats its level with the severity and activity of psoriatic arthritis. Methods: This case control study included ( 50) subjects classified into two groups: Group I: 30 patients with psoriatic arthritis. Group II: 20 healthy age and sex matched individuals as a control group. Results: there were no statistically significant differences between case group and control group, with a mean value of 42.45±12.90 vs 41.05±9.84 respectively. Regarding sclerostin , it found that there were no statistically significant differences between case group and control group with a mean value of 2787.92±1838.06 vs 2235.53±1830.67 respectively, And it found that there were highly statistically significant differences between groups with high mean value in patients with psoriasis group of 4276.72±1239.7 when it compared with other groups. Conclusion: The significantly higher serum sclerostin levels in PsA patients, compared with controls; there was positive significant correlation between sclerostin and each of age and PASI score. Sclerostin plays an important role in the pathogenesis of PsA and its associated bone damage, either systemic or localized.

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Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis

et al. 2022

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Evidence has shown that gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders such as psoriasis. The gut–skin axis refers to the bidirectional relationship between the gut microbiome and skin health. This is regulated through several mechanisms such as inflammatory mediators and the immune system. Dysregulation of microbiota has been seen in numerous inflammatory skin conditions such as atopic dermatitis, rosacea, and psoriasis. Understanding how gut microbiome are involved in regulating skin health may lead to development of novel therapies for these skin disorders through microbiome modulation, in particularly psoriasis. In this review, we will compare the microbiota between psoriasis patients and healthy control, explain the concept of gut–skin axis and the effects of gut dysbiosis on skin physiology. We will also review the current evidence on modulating gut microbiome using probiotics in psoriasis.

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Handbook of Psoriasis and Psoriatic Arthritis

Cited by 5 publications

References 57 publications

Impact of moderate-to-severe psoriasis on quality of life in China: a qualitative study

Impact of moderate-to-severe psoriasis on quality of life in China: a qualitative study

Evaluation of Serum Level of Sclerostin in Patients with Psoriatic Arthritis

Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis

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