Handgrip strength and respiratory disease mortality: Longitudinal analyses from SHARE

Mey, Rochelle; Calatayud, Joaquín; Casaña, José; Torres‐Castro, Rodrigo; Cuenca‐Martínez, Ferrán; Suso‐Martí, Luis; Andersen, Lars L.; López‐Bueno, Rubén

doi:10.1016/j.pulmoe.2022.09.007

Cited by 6 publications

(1 citation statement)

References 32 publications

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“…No difference was found between HGS of the 7th day and the clinical status on the 28th day, nor between HGS of the 1st day and LOS. According to previous studies, lower HGS was associated with higher mortality from a respiratory disease [ 42 ]. Cheval et al indicated that muscle strength is an independent risk factor for COVID-19 severity in adults aged 50 and older [ 27 ].…”

Section: Discussionmentioning

confidence: 98%

Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients

et al. 2023

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Phase angle (PhA) and muscle strength are predictors of clinical outcomes in critically ill patients. Malnutrition may affect body composition measurements. The aim of this prospective study was to investigate the association between PhA and handgrip strength (HGS), and clinical outcomes in hospitalized COVID-19 patients. The study included a total of 102 patients. Both PhA and HGS were measured twice, within 48 h of hospital admission and on the 7th day of hospitalization. The primary outcome was the clinical status on the 28th day of hospitalization. Secondary outcomes included the hospital length of stay (LOS), the concentrations of ferritin, C-reactive protein and albumin, oxygen requirements and the severity of pneumonia. A one-way analysis of variance (ANOVA) test and Spearman rS correlation coefficient were used for statistical analysis. No differences were found for PhA [on day 1 (p = 0.769) and day 7 (p = 0.807)] and the primary outcome. A difference was found between HGS on day 1 and the primary outcome (p = 0.008), while no difference was found for HGS on day 7 (p = 0.476). Body mass index was found to be associated with the oxygen requirement on day 7 (p = 0.005). LOS was correlated neither with PhA (rs = −0.081, p = 0.422) nor with HGS (rs = 0.137, p = 0.177) on the first day. HGS could be a useful indicator of clinical outcomes in COVID-19 patients, while PhA does not seem to have a clinical impact. However, further research is needed to validate the results of our study.

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Section: Discussionmentioning

confidence: 98%

Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients

et al. 2023

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Association of Muscle Strength With All‐Cause Mortality in the Oldest Old: Prospective Cohort Study From 28 Countries

Andersen,

López‐Bueno,

Núñez‐Cortés

et al. 2024

J cachexia sarcopenia muscle

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BackgroundAgeing is associated with a gradual loss of muscle strength, which in the end may have consequences for survival. Whether muscle strength and mortality risk associate in a gradual or threshold‐specific manner remains unclear. This study investigates the prospective association of muscle strength with all‐cause mortality in the oldest old.MethodsWe included 1890 adults aged ≥ 90 years (61.6% women, mean age 91.0 ± 1.5 years) from 27 European countries and Israel participating in the Survey of Health, Ageing and Retirement in Europe (SHARE) study. Muscle strength was assessed using handgrip dynamometry (unit: kilogram). Using time‐varying Cox regression with restricted cubic splines, we determined the prospective association of muscle strength with mortality, controlling for age, sex, smoking, BMI, marital status, education, geographical region and self‐perceived health.ResultsOver a mean follow‐up of 4.2 ± 2.4 years, more than half of the participants died (n = 971, 51.4%). The mean handgrip strength was 20.4 ± 8.0 kg for all participants, with men (26.7 ± 7.5 kg) showing significantly higher strength than women (16.4 ± 5.4 kg) (p < 0.001). Using the median level of muscle strength as reference (18 kg), lower and higher levels were associated in a gradual and curvilinear fashion with higher and lower mortality risk, respectively. The 10th percentile of muscle strength (10 kg) showed a hazard ratio (HR) of 1.27 (95% CI 1.13–1.43, p < 0.001). The 90th percentile (31 kg) showed an HR of 0.69 (95% CI 0.58–0.82, p < 0.001). Stratified for sex, the median levels of muscle strength were 26 kg for men and 16 kg for women. The 10th percentile of muscle strength showed HRs of 1.33 (95% CI 1.10–1.61, p < 0.001) at 15 kg for men and 1.19 (95% CI 1.05–1.35, p < 0.01) at 10 kg for women. The 90th percentile of muscle strength showed HRs of 0.75 (95% CI 0.59–0.95, p < 0.01) at 35 kg for men and 0.75 (95% CI 0.62–0.90, p < 0.001) at 23 kg for women. Sensitivity analyses, which excluded individuals who died within the first 2 years of follow‐up, confirmed the main findings.ConclusionRather than a specific threshold, muscle strength is gradually and inversely associated with mortality risk in the oldest old. As muscle strength at all ages is highly adaptive to resistance training, these findings highlight the importance of improving muscle strength in both men and women among the oldest old.

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Consideration and Assessment of Patient Factors When Selecting an Inhaled Delivery System in COPD

Mahler,

Halpin

2024

CHEST

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Handgrip strength and respiratory disease mortality: Longitudinal analyses from SHARE

Cited by 6 publications

References 32 publications

Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients

Phase Angle and Handgrip Strength as Predictors of Clinical Outcomes in Hospitalized COVID-19 Patients

Association of Muscle Strength With All‐Cause Mortality in the Oldest Old: Prospective Cohort Study From 28 Countries

Consideration and Assessment of Patient Factors When Selecting an Inhaled Delivery System in COPD

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