Handgrip Strength and Risk of Atrial Fibrillation

Kunutsor, Setor K; Mäkikallio, Timo H.; Jae, Sae Young; Khan, Hassan; Voutilainen, Ari; Laukkanen, Jari A

doi:10.1016/j.amjcard.2020.10.006

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…Our findings were consistent with a previous observational study showing that handgrip strength was negatively association with AF ( 34 ). The results of this study indicated that the HRs were 0.73 (95%CI, 0.61–0.86) for AF per one standard deviation increase in handgrip strength.…”

Section: Discussionsupporting

confidence: 94%

Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study

Zhuo

Zhao²,

Wang³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSeveral observational studies have identified that handgrip strength was inversely associated with cardiovascular diseases (CVDs). Nevertheless, causality remains controversial. We conducted Mendelian randomization (MR) analysis to examine whether handgrip strength and risk of CVDs are causally associated.MethodsWe identified 160 independent single nucleotide polymorphisms (SNPs) for right-hand grip strength and 136 independent SNPs for left-hand grip strength at the genome-wide significant threshold (P < 5 × 10−8) from UK Biobank participants and evaluated these in relation to risk of CVDs. MR estimates was calculated using the inverse-variance weighted (IVW) method and multiple sensitivity analysis was further conducted.ResultsGenetical liability to handgrip strength was significantly associated with coronary artery disease (CAD) and myocardial infarction (MI), but not stroke, hypertension, or heart failure. Additionally, there was significant association between right-hand grip strength and atrial fibrillation (OR, 0.967; 95% CI, 0.950–0.984; p = 0.000222), however, suggestive significance was found between left-hand grip strength and atrial fibrillation (OR, 0.977; 95% CI, 0.957–0.998; p = 0.033). Results were similar in several sensitivity analysis.ConclusionOur study provides support at the genetic level that handgrip strength is negatively associated with the risk of CAD, MI, and atrial fibrillation. Specific handgrip strength interventions on CVDs warrant exploration as potential CVDs prevention measures.

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Section: Discussionsupporting

confidence: 94%

Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study

Zhuo

Zhao²,

Wang³

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…However, it should be noted that this particular study utilized raw HGS values rather than taking into account body weight. In a similar study of 827 older men and women with no history of atrial fibrillation at baseline, 36 HGS was assessed, and values were scaled to account for the effect of body weight. During a median follow-up of 15.7 years, 265 cases of atrial fibrillation were diagnosed.…”

Section: Discussionmentioning

confidence: 99%

Association between baseline levels of muscular strength and risk of stroke in later life: The Cooper Center Longitudinal Study

Farrell,

Leonard,

et al. 2024

Journal of Sport and Health Science

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Handgrip Strength and Risk of Atrial Fibrillation

Cited by 2 publications

References 11 publications

Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study

Assessment of causal associations between handgrip strength and cardiovascular diseases: A two sample mendelian randomization study

Association between baseline levels of muscular strength and risk of stroke in later life: The Cooper Center Longitudinal Study

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