Handgrip strength as a means of monitoring progression of cognitive decline – A scoping review

Fritz, Nora; McCarthy, Caitlin J.; Adamo, Diane E.

doi:10.1016/j.arr.2017.01.004

Cited by 158 publications

(168 citation statements)

References 63 publications

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“…However, most of these observational studies considered only cross-sectional associations of muscular strength and specific cognitive function score, therefore limiting conclusions with regard to long-term decline in muscle strength (Chang et al 2016). Several studies have investigated the longitudinal association between muscle strength and cognitive function (Fritz et al 2017). One community-based 3.5-year follow-up study, reported that handgrip strength was linked to the greater variability of memory decline in a small sample of 426 elderly individuals (Christensen et al 1999), with an alternative study reporting that low handgrip strength was associated with an MMSE (score, mean ± SD) 27.4 ± 1.6 27.6 ± 1.5 26.9 ± 1.7 < 0.001 Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, longitudinal studies, based on 20-year follow up data for a population (Sternang et al 2016), identified that changes in handgrip strength are associated with changes in cognitive abilities. Moreover, a recent review of longitudinal studies investigated the association between sarcopenia (muscle mass and/or strength) and cognitive function, and indicated a decline of these conditions in elderly individuals (Fritz et al 2017). However, evidence on the contributing relation- Table 3.…”

Section: Discussionmentioning

confidence: 99%

“…Although the association between muscle mass or strength and cognitive function has been well documented cross-sectionally in elderly individuals, longitudinal studies are still required to understand the causality of these associations. Moreover, a recent review of longitudinal studies that have investigated the association between sarcopenia (decline in muscle mass or strength) and cognitive function indicated a decline in elderly individuals (Fritz et al 2017). However, the prospective association is still not certain in the general population, including in middle-aged adults (Alfaro-Acha et al 2006;Mori et al 2016).…”

Section: Introductionmentioning

confidence: 99%

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Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Jeong

Kim

2018

Tohoku J. Exp. Med.

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Dementia is one of the priority public health problems in the older population, and the number of people with dementia is steadily increasing. The longitudinal association of muscle strength with risk of new-onset cognitive dysfunction in a general population including middle and older adults remains unknown. The purpose of this study was to investigate the effects of low muscle strength on risk for new-onset cognitive dysfunction over 6 years using a large nationwide sample of cognitively healthy adults. Study participants included 6,435 middle and older adults (33,554 person-years of follow-up), using data from the Korean Longitudinal Study of Ageing 2006-2012. Muscular strength was measured using the maximum handgrip strength of each participant as an index of muscle quality. Low muscle strength was defined as one standard deviation below the mean using the handgrip strength index based on the study population. Cognitive function was evaluated using the Mini-Mental Status Evaluation. The hazard ratio (HR) for cognitive dysfunction significantly and linearly increased according to muscle strength status independent of potential confounding factors (HR: 1.36, 95% confidence interval [CI]: 1.18-1.56 for low vs. normal-high group). Using stratified analyses, a significant association between muscle strength status and risk of cognitive impairment was observed in those with low physical activity, but not those with high physical activity. We show that handgrip strength is associated with increased risk of new-onset cognitive dysfunction over 6 years of follow-up in cognitively healthy middle aged and older adults at baseline.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Jeong

Kim

2018

Tohoku J. Exp. Med.

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“…[6][7][8] Changes in the performance of motor tasks (eg, handgrip strength and gait) have been associated with changes in cognition and are a harbinger of impending cognitive decline. [6][7][8] Changes in the performance of motor tasks (eg, handgrip strength and gait) have been associated with changes in cognition and are a harbinger of impending cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

Associations between handgrip strength and mild cognitive impairment in middle‐aged and older adults in six low‐ and middle‐income countries

Vancampfort

Stubbs

Firth

et al. 2019

Int J Geriat Psychiatry

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Objectives A number of small‐scale, single‐country studies have suggested that muscular weakness may be a biomarker for cognitive health, mild cognitive impairment (MCI), and dementia. However, multinational, representative studies are lacking, particularly from low‐ and middle‐income countries (LMICs). Thus, we assessed the association between muscular strength (measured by maximal handgrip) and MCI in six LMICs (China, Ghana, India, Mexico, Russia, and South Africa), using nationally representative data. Methods Cross‐sectional, community‐based data on individuals aged 50 years or older from the World Health Organization's Study on Global Ageing and Adult Health were analyzed. MCI was defined according to the National Institute on Aging‐Alzheimer's Association criteria. Weak handgrip strength was defined as less than 30 kg for men and less than 20 kg for women using the average value of two handgrip measurements of the dominant hand. Multivariable logistic regression analysis was conducted to assess the association between muscular strength and MCI. Results A total of 32 715 participants were included (mean age 62 ± SD 15.6 y and 51.7% female). The prevalence of MCI and weak handgrip strength was 15.3% (95% CI, 14.4%‐16.3%) and 46.5% (95% CI, 43.6%‐49.5%), respectively. After adjustment for potential confounders, weak handgrip strength was associated with 1.41 (95% CI, 1.23‐1.61) times higher odds for MCI. The corresponding figures for those aged 50 to 64 years and 65 years or older were 1.35 (95% CI, 1.14‐1.60) and 1.54 (95% CI, 1.27‐1.86), respectively. Conclusions Muscular weakness may provide a clinically useful indicator of MCI risk. Increasing our understanding of the connection between muscular and cognitive function could ultimately lead to the development and broader implementation of resistance training interventions targeting both physical and cognitive health.

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“…Cognitive loss is associated with low and declining muscle strength in the general population [23, 24]. A widely used way of assessing muscle strength is by the strength of handgrip.…”

Section: Introductionmentioning

confidence: 99%

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

Kovářová¹,

Valeriánová²,

Kmentova³

et al. 2018

Nephron

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Background/Aims: High rates of cognitive impairment (CI) are an alarming problem in patients undergoing chronic hemodialysis (HD). Its pathophysiology remains unclear and there are indications that brain ischemia might be one of the key causes. Cerebral tissue oxygenation, as measured by near-infrared spectroscopy, is known to be decreased in HD patients. However, it is unknown whether CI is associated or not associated with lower cerebral oxygenation in these patients. The primary aim of our study was to probe this possible association. Our secondary aim was to assess other factors possibly related to cerebral ischemia and CI. Methods: Thirty-nine patients treated by chronic HD were included in this cross-sectional study. All measurements were performed before the initiation of an HD session. The Montreal Cognitive Assessment (MoCA) was administered according to published recommendations. Regional saturation of oxygen (rSO2) of the left frontal lobe was measured using the INVOS 5100C device. Basic medical history and laboratory data were recorded, and handgrip strength was analyzed. We used the unpaired t test to compare the rSO2 and other variables between cognitively normal patients (MoCA score ≥26) and those who displayed CI (MoCA score <26). Multiple linear regression analysis was used to adjust for principal confounders. Results: Cognitively impaired patients had lower brain rSO2 values compared to cognitively normal patients (48 ± 9 vs. 57 ± 10%, p = 0.01). Among other variables, higher red cell distribution width (15.8 ± 1.9 vs. 13.8 ± 1.6%, p = 0.01) and lower hand grip strength (49.2 ± 23.3 vs. 99.3 ± 31.4 lbs, p < 0.001) also displayed a significant association with CI. The relation between rSO2 and MoCA score was significant after adjustment for age and gender (p = 0.007). Conclusion: Decreased brain oxygenation is associated with weaker cognitive performance in patients undergoing chronic HD. Further understanding the causes of cerebral ischemia in HD patients could lead to the prevention of cognitive decline in this population.

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Handgrip strength as a means of monitoring progression of cognitive decline – A scoping review

Cited by 158 publications

References 63 publications

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Associations between handgrip strength and mild cognitive impairment in middle‐aged and older adults in six low‐ and middle‐income countries

Low Cerebral Oxygenation Is Associated with Cognitive Impairment in Chronic Hemodialysis Patients

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