Handgrip strength is inversely associated with augmentation index in patients with type 2 diabetes

Hamasaki, Hidetaka; Yanai, Hidekatsu

doi:10.1038/s41598-023-28392-8

Cited by 5 publications

(11 citation statements)

References 66 publications

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“…Age-related decreases in muscle strength, mass, and function are referred to as sarcopenia, which can result in reduced physical performance and an increased risk of adverse health outcomes. Among these, HGS, which indicates skeletal muscle strength [ 2 ], is a key factor of sarcopenia and is used as a biomarker, which is consistent in explaining bone mineral density, fractures, quality of life, diabetes, arterial stiffness, cardiovascular disease, and all-cause mortality [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Dixon et al showed that weak grip strength is associated with an increased risk of vertebral fracture and poor bone mineral density in the hips and spine in women [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…A study revealed that grip strength was lower in adults (aged ≥ 20 years) with diabetes with no history of cardiovascular disease [ 30 ]. Several studies have shown that HGS is negatively associated with arterial stiffness in non-hypertensive participants, patients with diabetes, and patients with chronic coronary syndrome [ 31 , 32 , 33 ]. Moreover, weak grip strength was associated with a higher risk of mortality from cardiovascular disease, respiratory disease, and cancer in a prospective cohort study of half a million UK Biobank participants [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study

Kwon,

Cho,

Park

et al. 2024

JCM

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Background: Sarcopenia is defined as the loss of muscle mass and strength and low physical performance, and it is closely related to the risk of cardiovascular disease and mortality. Pulse pressure (PP) is a biomarker of arterial stiffness and compliance. Elevated PP levels increase the risk of cardiovascular diseases and all-cause mortality. Nevertheless, the association between PP and sarcopenia has not yet been clearly established. Methods: Participant data were extracted from the Korea National Health and Nutrition Examination Survey conducted from 2014 to 2020. The study population was classified into three groups (PP < 40 mmHg, 40 mmHg ≤ PP < 60 mmHg, and PP ≥ 60 mmHg). PP was calculated by deducting the diastolic blood pressure from the systolic blood pressure. For handgrip strength, the maximum value measured with a grip dynamometer was adopted (weak handgrip strength: <28 kg for men, <18 kg for woman; normal handgrip strength: ≥28 kg for men, ≥18 kg for women). To determine the relationship between PP and the prevalence of weak handgrip strength, multiple logistic regression analysis was performed after adjusting for possible confounding factors. Results: The higher PP group had a higher age, body mass index; systolic blood pressure, prevalence of hypertension, diabetes, hyperlipidemia, and metabolic syndrome, and maximum handgrip strength. In all models, the prevalence of weak handgrip strength was significantly higher in the group with PP ≥ 60 mmHg compared to the control group (PP < 40 mmHg). Conclusions: Elevated PP was significantly associated with a higher prevalence of weak muscle strength. Thus, PP monitoring may be used to identify individuals at risk of sarcopenia and is helpful in improving health outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study

Kwon,

Cho,

Park

et al. 2024

JCM

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“…These studies showed both lower values of grip strength and higher values of AIx@75% than those obtained in the present study, consistent with their older age and their a diagnosis with two of the chronic pathologies that are commonly associated with an increased arterial stiffness. They observed a negative correlation between HGS/Kg and AIx@75% [ 20 , 33 ]. Another study found a negative correlation between maximum dynamic strength and AIx@75% in individuals with mobility limitations and a mean age of 68 years [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…The methodology and results of the present study do not permit us to determine the physiological and/or molecular mechanisms that describe the influence of HGS on arterial stiffness. However, there are common factors that may contribute to low muscle strength, as well as an increased arterial stiffness, including oxidative stress, insulin resistance, increased body fat percentage, endothelial dysfunction and the presence of higher levels of circulating inflammatory markers (elevated levels of C-reactive protein, interleukin-6, D-dimer, factor VIII) [ 33 , 62 , 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

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Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome

Sánchez-Delgado,

Cohen,

Camacho-López

et al. 2023

Biomedicines

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Background: Metabolic syndrome (MetS) is a disorder associated with an increased risk for the development of diabetes mellitus and its complications. Lower isometric handgrip strength (HGS) is associated with an increased risk of cardiometabolic diseases. However, the association between HGS and arterial stiffness parameters, which are considered the predictors of morbidity and mortality in individuals with MetS, is not well defined. Objective: To determine the association between HGS and HGS asymmetry on components of vascular function in adults with MetS. Methods: We measured handgrip strength normalized to bodyweight (HGS/kg), HGS asymmetry, body composition, blood glucose, lipid profile, blood pressure, pulse wave velocity (PWV), reflection coefficient (RC), augmentation index @75 bpm (AIx@75) and peripheral vascular resistance (PVR) in 55 adults with a diagnosis of MetS between 25 and 54 years old. Results: Mean age was 43.1 ± 7.0 years, 56.3% were females. HGS/kg was negatively correlated with AIx@75 (r = −0.440), p < 0.05, but these associations were not significant after adjusting for age and sex. However, when interaction effects between sex, HGS/kg and age were examined, we observed an inverse relationship between HGS/kg and AIx@75 in the older adults in the sample, whereas in the younger adults, a weak direct association was found. We also found a significant association between HGS asymmetry and PVR (beta = 30, 95% CI = 7.02; 54.2; p <0.012). Conclusions: Our findings suggest that in people with MetS, maintaining muscle strength may have an increasingly important role in older age in the attenuation of age-related increases in AIx@75—a marker of vascular stiffness—and that a higher HGS asymmetry could be associated with a greater vascular resistance.

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Association of skeletal muscle mass and risk of hypertension in Korean adults: secondary analysis of data from the community-based prospective cohort study

2023

Front. Nutr.

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BackgroundCross-sectional studies have revealed a link between low muscle mass and hypertension. However, whether the degree of muscle mass predicts hypertension risk has not been confirmed. This study aimed to verify an association between skeletal muscle mass and incident hypertension in a longitudinal follow-up of middle-aged Korean adults.MethodsThe community-based prospective Korean Genome and Epidemiology Study (KoGES) data from 2,669 participants who were free of hypertension at baseline were prospectively assessed at 2-year intervals for 16 years. The participants were divided into tertiles T1–T3 of relative skeletal muscle mass (RSM) according to their baseline whole-body skeletal muscle mass measured as bioelectrical impedance. Incident hypertension was estimated using multivariate logistic regression with the Cox proportional hazard regression model.ResultsOver the 16-year follow-up, the rates of incident hypertension at RSM T1, T2, and T3 were 18.7, 17.1, and 13.4% in men (P for trend = 0.0002) and 18.8, 14.7, and 12.9% in women (P for trend = 0.0007), respectively. The multivariate adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for the incidence of hypertension for men and women in T1 and T2 were 1.36 (1.11–1.67) and 1.59 (1.31–1.94), and 1.20 (0.99–1.46) and 1.70 (1.41–2.04), respectively, compared with T3 as the reference.ConclusionA low skeletal muscle mass in middle-aged Korean men and women was significantly associated with incident hypertension in later life. Further investigation is needed to comprehend the mechanisms of this relationship and validate the findings in a large cohort.

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Handgrip strength is inversely associated with augmentation index in patients with type 2 diabetes

Cited by 5 publications

References 66 publications

Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study

Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study

Handgrip Strength Is Associated with Specific Aspects of Vascular Function in Individuals with Metabolic Syndrome

Association of skeletal muscle mass and risk of hypertension in Korean adults: secondary analysis of data from the community-based prospective cohort study

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