Handheld multispectral confocal microscope for cervical cancer diagnosis

Rattanavarin, Santi; Sarapukdee, Pongsak; Jarujareet, Ungkarn; Khemthongcharoen, Numfon; Ruangpracha, Athisake; Jolivot, Romuald; Jung, Il Woong; López, Daniel; Mandella, Michael J.; Piyawattanametha, Wibool

doi:10.1109/omems.2012.6318792

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…MEMS scanners were made up of a single SOI layer having the dimension of 3.25mm x 3.25mm, with the thickness of 10 micrometers. The scanner is designed for achieving biaxial degree of freedom and is actuated by electrostatic driving force [2]. Device 1 possesses asymmetric torsional mirror design while device 2 has symmetric torsional mirror design as shown in Fig.…”

Section: Methodsmentioning

confidence: 99%

“…For early diagnosis of the disease, a non-invasive early detection technique for cervical cancer has been developed by using a handheld multispectral confocal microscope employing a two-dimensional (2-D) MEMS scanner as a key scanning element to raster laser beam [2,3,4]. The purpose of this work is to investigate the driving waveforms used to actuate MEMS scanners and determine suitable driving waveforms to raster scan the laser beam to obtain confocal imaging.…”

Section: Introductionmentioning

confidence: 99%

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Characteristics of MEMS scanners with different driving bias

Tantipiriyakij

Sankatumvong

Sarapukdee

et al. 2012

2012 IEEE International Conference on Electron Devices and Solid State Circuit (EDSSC)

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Characteristics of MEMS scanners with different driving bias

Tantipiriyakij

Sankatumvong

Sarapukdee

et al. 2012

2012 IEEE International Conference on Electron Devices and Solid State Circuit (EDSSC)

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“…Many bioimaging researchers use compact and ultracompact cameras in both laboratory settings and clinical settings. Systems have been built for light-field microscopes, 32 , 43 , 47 , 60 confocal imaging microscope, 229 , 230 fundus cameras, 54 , 55 endoscopes, 46 , 48 , 56 , 140 , 200 , 231 laparoscope, 63 , 65 , 66 , 70 colposcope, 51 , 52 and otoscope. 59 Spectral imaging for biomedical purposes has its own specifications that influence the choice of systems.…”

Section: Applications Of Compact Spectral Cameras In Biomedical Imagingmentioning

confidence: 99%

Compact and ultracompact spectral imagers: technology and applications in biomedical imaging

Tran

Fei

2023

J. Biomed. Opt.

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. Significance Spectral imaging, which includes hyperspectral and multispectral imaging, can provide images in numerous wavelength bands within and beyond the visible light spectrum. Emerging technologies that enable compact, portable spectral imaging cameras can facilitate new applications in biomedical imaging. Aim With this review paper, researchers will (1) understand the technological trends of upcoming spectral cameras, (2) understand new specific applications that portable spectral imaging unlocked, and (3) evaluate proper spectral imaging systems for their specific applications. Approach We performed a comprehensive literature review in three databases (Scopus, PubMed, and Web of Science). We included only fully realized systems with definable dimensions. To best accommodate many different definitions of “compact,” we included a table of dimensions and weights for systems that met our definition. Results There is a wide variety of contributions from industry, academic, and hobbyist spaces. A variety of new engineering approaches, such as Fabry–Perot interferometers, spectrally resolved detector array (mosaic array), microelectro-mechanical systems, 3D printing, light-emitting diodes, and smartphones, were used in the construction of compact spectral imaging cameras. In bioimaging applications, these compact devices were used for in vivo and ex vivo diagnosis and surgical settings. Conclusions Compact and ultracompact spectral imagers are the future of spectral imaging systems. Researchers in the bioimaging fields are building systems that are low-cost, fast in acquisition time, and mobile enough to be handheld.

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“…We used a gold coated barbell shaped MEMS scanner ( Fig. 2a) with die size of 3.25 × 3.25 mm 2 designed by Argonne National Laboratory and fabricated at Silex Microsystems Inc. [6]. The MEMS scanner requires 3 different voltages to scan in 2D.…”

Section: A Mems Scanner and Confocal Microscopementioning

confidence: 99%

“…The MEMS scanner can actuate electrostatically in 3 directions. V1 and V2 are used for driving the outer axis while V3 is for the inner axis (V4 is shorted to ground) [6]. The optical rotation from the MEMS scanner is recorded by the PSD via a LabView program.…”

Section: A Mems Scanner and Confocal Microscopementioning

confidence: 99%