Plant-Derived Natural Products 2009
DOI: 10.1007/978-0-387-85498-4_11
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Handling Dangerous Molecules: Transport and Compartmentation of Plant Natural Products

Abstract: The plant cell faces a dilemma: secondary products provide a multitude of defence and signalling functions, but their biosynthesis poses a severe burden, as it competes for energy sources and building blocks and may generate toxic products. Thus, evolution of recent secondary metabolites is not only driven by their advantageous functions but also selects for strict control mechanisms including the integration of biosynthesis into the cellular ultrastructure. In order to minimize the risk of self-intoxication, … Show more

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Cited by 6 publications
(7 citation statements)
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References 231 publications
(230 reference statements)
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“…How biosynthesis and deposition of flavonoids affect the biogenesis and/or maintenance of vacuoles, and whether vacuoles are filled with flavonoids via tonoplast transporters only or additionally/alternatively by vesicle‐mediated transport mechanisms, remain matters of debate. Both TT12 and TT13 mutants contain carboxy‐DCFDA‐stainable fragmented vacuole structures in ii1 cells instead of large central vacuoles (Baxter et al ., ; Klein and Roos, ), and mutants of both accumulate vanillin‐reactive PAs outside these structures (Kitamura et al ., and Figure ). After their synthesis, TT12 and TT13 proteins probably reside on ER‐derived transport vesicles in endothelium cells (Zhao and Dixon, ).…”
Section: Discussionmentioning
confidence: 99%
“…How biosynthesis and deposition of flavonoids affect the biogenesis and/or maintenance of vacuoles, and whether vacuoles are filled with flavonoids via tonoplast transporters only or additionally/alternatively by vesicle‐mediated transport mechanisms, remain matters of debate. Both TT12 and TT13 mutants contain carboxy‐DCFDA‐stainable fragmented vacuole structures in ii1 cells instead of large central vacuoles (Baxter et al ., ; Klein and Roos, ), and mutants of both accumulate vanillin‐reactive PAs outside these structures (Kitamura et al ., and Figure ). After their synthesis, TT12 and TT13 proteins probably reside on ER‐derived transport vesicles in endothelium cells (Zhao and Dixon, ).…”
Section: Discussionmentioning
confidence: 99%
“…Initial rates of sanguinarine reduction were thus determined with NADPH and in the presence of 2 mM glutathione. The latter compound spontaneously complexes sanguinarine (15) with a K D of 400 M. 3 Under such conditions, the substrate supply is controlled and stabilized by the dissociation of the sanguinarine-glutathione complex. Consequently, the rate of product formation slows down to ϳ10% of the initial rate, and the enzyme displays saturation kinetics without significant product inhibition (supplemental Fig.…”
Section: Methodsmentioning
confidence: 99%
“…A less known but equally important mechanism of protection against self-intoxication is the coordinated expression of stress-protective and detoxifying enzymes. The value of protective and detoxifying enzymes is exemplified well by the management of the cytotoxic benzophenanthridine alkaloids, which are produced mainly in Papaverceae and some Ranunculaceae (1)(2)(3). The induction of biosynthesis of this alkaloid by pathogens and endogenous signals has been best investigated in cultured cells (4 -6).…”
mentioning
confidence: 99%
“…Plants have developed several strategies to keep secondary biosynthesis compatible with the fitness of the producer. Much is known about the compartmentation and channeling of enzymes and metabolites that separate intermediates and products from basic metabolism, as exemplified by precursor pools, metabolons, and intracellular trafficking, e.g., in the biosynthesis of flavonoids or benzylisoquinolines (for a review, see Klein and Roos, 2009). Less information exists about the metabolic detoxification of end products, as exemplified by the recycling of benzophenanthridine alkaloids (Weiss et al, 2006;Müller et al, 2014).…”
Section: Introductionmentioning
confidence: 99%