Abstract-Anal cancer occurs very rare in our population. Its treatment depends on the advancement of the process. Occasionally, the lesions are removed surgically, but most of advanced lesions are treated by radiotherapy and chemotherapy, also combined with surgical removal. Sometimes the combination therapy is difficult to perform, in cases when there is no possibility to protect the bowels against the direct side effects of radiotherapy due to wide excision. In most complicated and non-healing wounds, negative pressure therapy significantly improves the treatment results. This kind of treatment has also its restrictions: main contraindication is an active malignant process, however, it is reported that in some cases it has achieved positive effects.68 years-old man was admitted to the Proctological Outpatient Office because of perianal genital warts. Histological examination diagnosed them as condylomata acuminata but when the patient reported back to the same Outpatient Office after 2 years, he presented with a giant perianal tumor. Because of severe problems with passing stool, size of the lesions, sphincter infiltration and its full dysfunction, abdominoperineal rectal resection with end colostomy was performed. In the histological examination anal cancer was recognized: stage IIIA: T3N1M0 and further radiotherapy and chemotherapy were indicated. An open, nonhealing wound was a contraindication for radiotherapy. Despite the potential malignancy in the wound, the negative pressure wound therapy (with the continuous pressure -100 mmHg) was introduced. After 20 days of treatment, the wound was closed by granulation. Patient was qualified to the radiation therapy (60 Gy) combined with 5-FU and Mitomycin C, with good results.In our case, applying negative pressure wound therapy resulted in wound closing and allowed to introduce the main way of healing -radiotherapy, suggesting that NPWT can be used as supportive management of neoplastic diseases.