Let p n (x), n = 0, 1, . . . , be the orthogonal polynomials with respect to a given density dµ(x). Furthermore, let dν(x) be a density which arises from dµ(x) by multiplication by a rational function in x. We prove a formula that expresses the Hankel determinants of moments of dν(x) in terms of a determinant involving the orthogonal polynomials p n (x) and associated functions q n (x) = p n (u) dµ(u)/(x − u). Uvarov's formula for the orthogonal polynomials with respect to dν(x) is a corollary of our theorem. Our result generalises a Hankel determinant formula for the case where the rational function is a polynomial that existed somehow hidden in the folklore of the theory of orthogonal polynomials but has been stated explicitly only relatively recently (see [arχiv:2101.04225]). Our theorem can be interpreted in a two-fold way: analytically or in the sense of formal series. We apply our theorem to derive several curious Hankel determinant evaluations.1. Introduction. Recently,in [5] this author discovered a formula that expresses the Hankel determinant of linear combinations of moments of orthogonal polynomials in terms of a determinant involving these orthogonal polynomials. A literature search revealed that this formula existed in a hidden form behind a theorem (cf. [7, Theorem 2.5] or [3, Theorem 2.7.1]) that is commonly attributed to Christoffel [1] (although he had only proved it in a very special case); only recently it had been stated explicitly, by Lascoux in [6, Prop. 8.4.1] (although incorrectly) and by Elouafi [2, Theorem 1] (however with an incomplete proof). Three fundamentally different proofs are given in [5]: one due to this author, one following Lascoux's arguments, and one completing Elouafi's arguments.The purpose of this article is to present and prove a generalisation of the aforementioned formula that is inspired by Uvarov's formula [8,9] for the orthogonal polynomials with