Hantavirus epidemic In Europe, 1993

Clément, Jan; McKenna, Paula; Colson, Paul W.; Damoiseaux, Ph; Penalba, C; Halin, Pascale; Lombart, D.; Guenno, B. Le; Camprasse, Marie-Alice; Guilbaut, JeanCharles; Lanoux, P.; Hoën, Bruno; P, Rollin; Coudrier, D.; Sureau, P.

doi:10.1016/s0140-6736(94)90841-9

Cited by 51 publications

(26 citation statements)

References 6 publications

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“…Recently we also investigated a patient with Guillain-Barre syndrome in association with HV infection [22]. The predominance of cases in males between 30 and 40 years of age, living in rural or forested areas, is also quite characteristic for NE cases observed in western Europe [6,7,10,18,23]. As in Germany, Belgium and France, NE cases occur throughout the year with a slight increase in the summer months.…”

Section: Discussionmentioning

confidence: 98%

“…Consequently the disease incidence peaks in these seasons. It is difficult to determine whether the recent increase in diagnosed cases of NE in The Netherlands is due to an increased awareness of the disease amongst the medical profession, or to an increased exposure of humans to infected rodents [3,23,25]. The recent outbreak of a previously unrecognized HV disease in the USA with a case fatality rate exceeding 60%, probably due to an increased exposure of humans to infected deer mice [3], stresses the need for a monitoring system for HV infections in humans and potential host animals.…”

Section: Discussionmentioning

confidence: 99%

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Hantavirus infections in The Netherlands: epidemiology and disease

et al. 1995

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SUMMARYA serological survey for the prevalence of hantavirus infections in The Netherlands was carried out on > 10000 sera, from selected human populations, and different feral and domestic animal species. Hantavirus-specific antibodies were found in about 1 % of patients suspected of acute leptospirosis, 10% of patients with acute nephropathia, and in less than 011% haemodialysis and renal transplant patients. Among individuals with a suspected occupational risk, 6 % of animal trappers, 4 % of forestry workers, 2 % of laboratory workers and 0-4 % of farmers were seropositive. The majority of the seropositive individuals lived in rural and forested areas. The main animal reservoir of the infection was shown to be the red bank vole (Clethrionomys glareolus). Epidemiological, clinical and laboratory findings seen in serologically confirmed human cases were similar to those associated with nephropathia epidemica.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Hantavirus infections in The Netherlands: epidemiology and disease

et al. 1995

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“…The renal symptoms begin around the 3rd day of illness, and the peak plasma creatinine level is reached around the end of the 1st week [2]. During the oliguric phase, maximum 6% of the hospitalized patients require transient renal replacement therapy (RRT) [12,13,16,20]. Within 2-3 weeks, oliguria is followed by polyuria and spontaneous recovery is the rule [12,13,14,15].…”

Section: Introductionmentioning

confidence: 99%

Community Acquired Severe Acute Kidney Injury Caused by Hantavirus-Induced Hemorrhagic Fever with Renal Syndrome Has a Favorable Outcome

Outinen¹,

Mäkelä²,

Clément³

et al. 2015

Nephron

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Background: Puumala hantavirus (PUUV) induces an acute tubulointerstitial nephritis and acute kidney injury (AKI). Our aim was to evaluate the prognosis of severe AKI associated with PUUV infection. Methods: We examined 556 patients who were treated at Tampere University Hospital during 1982-2013 for acute, serologically confirmed PUUV infection. Plasma creatinine was measured during hospitalization, convalescence, and 1, 2, and 5 years after the acute infection. Results: Plasma creatinine concentration was elevated (>100 μmol/l) in 459 (83%) patients, while altogether 189 patients (34%) had severe AKI defined as Kidney Disease: Improving Global Outcomes (KDIGO) stage 3, that is, plasma creatinine ≥353.6 μmol/l (4.0 mg/dl) or need of dialysis. There were no fatal cases during the hospitalization or the following 3 months. Fatality rate during the years following PUUV infection did not differ between patients who had suffered from severe AKI versus those without severe AKI. Post-hospitalization plasma creatinine values were available for 188 (34%) patients. One month after the acute infection, patients with prior severe AKI had higher median plasma creatinine concentration (82 µmol/l, range 54-184) than patients without severe AKI (74 µmol/l, range 55-109, p = 0.005). After 1 year, no significant difference existed in median plasma creatinine concentrations between patients with (71 µmol/l, range 36-123) and without prior severe AKI (72 µmol/l, range 34-116, p = 0.711). After 5 years all but 1 patient had normal creatinine levels. Conclusions: In contrast to the worldwide well-accepted KDIGO criteria, severe AKI associated with PUUV infection is not associated with excess fatality but has a very good prognosis, both in the short and long terms.

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“…As far as the temperate broadleaf forests are concerned, and from 1992 on, we noted that most NE cases occurred in the Ardennes (forested South of Belgium), on both sides of the Franco-Belgian border around the river Meuse, and particularly in very limited areas wherein beechnuts were abundant, and not so much acorns. That is, areas with a dense coverage of the same deciduous broad-leaf tree species, the European beech (Fagus sylvatica) seemed to predispose to an abundance of local bank voles, and consequently to outbreaks of NE (Clement et al, 1994b). Later on, with increased assessment of the spread of NE in temperate Europe, it became clear that the W.-European regions with the highest endemicity of NE, were exactly corresponding to the regions with a dense beech tree coverage, i.e.…”

Section: The Rodent Reservoir and Its Biotope: The Role Of The Beechmentioning

confidence: 99%

“…"Mast" is the common denomination for the seeds of deciduous broad-leaf trees, in this case mainly beechnuts, and to a lesser degree also acorns. Mast constitutes the main staple food for bank voles, and it was suggested since 1994 (Clement et al, 1994b) that a higher food supply in autumn (called further in the text "heavy masting") might promote a better winter survival and earlier spring breeding in voles, leading to rodent densities up to 20 times the norm starting at the next spring. Thus, after such a heavy "mast year", human population could be confronted from the next spring on with an ensuing "mice year", leading to NE outbreaks, and explaining also the observed NE cyclicity.…”

mentioning

confidence: 99%