Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Kallio, Eva R.; Begon, Michael; Henttonen, Heikki; Koskela, Esa; Mappes, Johanna; Vaheri, Antti; Vapalahti, Olli

doi:10.1098/rspb.2010.1022

Cited by 50 publications

(69 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal antibodies can have important effects on both individuals and populations (Kallio et al 2006(Kallio et al , 2010. However, since we were interested in the effect of infection on survival and these individuals were not infected, we chose to ignore the maternal antibodies and consider them as antibody negative.…”

Section: Discussionmentioning

confidence: 99%

Sin Nombre hantavirus decreases survival of male deer mice

et al. 2012

View full text Add to dashboard Cite

How pathogens affect their hosts is a key question in infectious disease ecology, and it can have important influences on the spread and persistence of the pathogen. Sin Nombre virus (SNV) is the etiological agent of hantavirus pulmonary syndrome (HPS) in humans. A better understanding of SNV in its reservoir host, the deer mouse, could lead to improved predictions of the circulation and persistence of the virus in the mouse reservoir, and could help identify the factors that lead to increased human risk of HPS. Using mark-recapture statistical modeling on longitudinal data collected over 15 years, we found a 13.4% decrease in the survival of male deer mice with antibodies to SNV compared to uninfected mice (both male and female). There was also an additive effect of breeding condition, with a 21.3% decrease in survival for infected mice in breeding condition compared to uninfected, non-breeding mice. The data identified that transmission was consistent with density-dependent transmission, implying that there may be a critical host density below which SNV cannot persist. The notion of a critical host density coupled with the previously overlooked disease-induced mortality reported here contribute to a better understanding of why SNV often goes extinct locally and only seems to persist at the metapopulation scale, and why human spillover is episodic and hard to predict.

show abstract

Section: Discussionmentioning

confidence: 99%

Sin Nombre hantavirus decreases survival of male deer mice

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The study took place at Konnevesi, Central Finland (62u 349 N 26u 249 E), where PUUV is endemic in bank voles (Kallio et al, 2007(Kallio et al, , 2009(Kallio et al, , 2010Razzauti et al, 2008). The study site is situated in the hospital district of Central Finland, where mean annual NE incidence is 71/100 000, the fourth highest of the 20 hospital districts in Finland (Makary et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Life-long shedding of Puumala hantavirus in wild bank voles (Myodes glareolus)

Voutilainen

Sironen

Tonteri

et al. 2015

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

The knowledge of viral shedding patterns and viraemia in the reservoir host species is a key factor in assessing the human risk of zoonotic viruses. The shedding of hantaviruses (family Bunyaviridae) by their host rodents has widely been studied experimentally, but rarely in natural settings. Here we present the dynamics of Puumala hantavirus (PUUV) shedding and viraemia in naturally infected wild bank voles (Myodes glareolus). In a monthly capture-mark-recapture study, we analysed 18 bank voles for the presence and relative quantity of PUUV RNA in the excreta and blood from 2 months before up to 8 months after seroconversion. The proportion of animals shedding PUUV RNA in saliva, urine and faeces peaked during the first month after seroconversion, but continued throughout the study period with only a slight decline. The quantity of shed PUUV in reverse transcription quantitative PCR (RT-qPCR) positive excreta was constant over time. In blood, PUUV RNA was present for up to 7 months but both the probability of viraemia and the virus load declined with time. Our findings contradict the current view of a decline in virus shedding after the acute phase and a short viraemic period in hantavirus infection -an assumption widely adopted in current epidemiological models. We suggest the life-long shedding as a means of hantaviruses to survive over host population bottlenecks, and to disperse in fragmented habitats where local host and/or virus populations face temporary extinctions. Our results indicate that the kinetics of pathogens in wild hosts may differ considerably from those observed in laboratory settings.

show abstract

“…Host traits, such as maternally derived antibody [20,21] and seasonal birthing [22,23], can affect infection dynamics within populations. Theoretical studies using stochastic epidemiological models with a seasonal birth pulse suggest that increased birthing synchrony increases the necessary population size required for infection persistence (CCS) [23].…”

Section: Introductionmentioning

confidence: 99%

Biannual birth pulses allow filoviruses to persist in bat populations

Hayman

2015

Proc. R. Soc. B.

109

View full text Add to dashboard Cite

Filoviruses Ebolavirus (EBOV) and Marburgvirus (MARV) cause haemorrhagic fevers with high mortality rates, posing significant threats to public health. To understand transmission into human populations, filovirus dynamics within reservoir host populations must be understood. Studies have directly linked filoviruses to bats, but the mechanisms allowing viral persistence within bat populations are poorly understood. Theory suggests seasonal birthing may decrease the probability of pathogen persistence within populations, but data suggest MARV may persist within colonies of seasonally breeding Egyptian fruit bats, Rousettus aegyptiacus. I synthesize available filovirus and bat data in a stochastic compartmental model to explore fundamental questions relating to filovirus ecology: can filoviruses persist within isolated bat colonies; do critical community sizes exist; and how do host-pathogen relationships affect spillover transmission potential? Synchronous annual breeding and shorter incubation periods did not allow filovirus persistence, whereas bi-annual breeding and longer incubation periods, such as reported for Egyptian fruit bats and EBOV in experimental studies, allowed persistence in colony sizes often found in nature. Serological data support the findings, with bats from species with two annual birth pulses more likely to be seropositive (odds ratio (OR) 4.4, 95% confidence interval (CI) 2.5-8.7) than those with one, suggesting that biannual birthing is necessary for filovirus persistence.

show abstract

Hantavirus infections in fluctuating host populations: the role of maternal antibodies

Cited by 50 publications

References 48 publications

Sin Nombre hantavirus decreases survival of male deer mice

Sin Nombre hantavirus decreases survival of male deer mice

Life-long shedding of Puumala hantavirus in wild bank voles (Myodes glareolus)

Biannual birth pulses allow filoviruses to persist in bat populations

Contact Info

Product

Resources

About