Hantavirus pulmonary syndrome in the United States

Fabbri, Marilyn; Maslow, Melanie J.

doi:10.1007/s11908-001-0028-1

Cited by 15 publications

(7 citation statements)

References 47 publications

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“…Approximately 300 cases of HCPS are reported each year in North and South America . SNV, which infects deer mouse, is the major cause of HCPS in North America (Fabbri and Maslow, 2001).…”

Section: A Epidemiologymentioning

confidence: 99%

Recent Advances in Hantavirus Molecular Biology and Disease

Hussein

Haseeb

Haque

et al. 2011

Advances in Applied Microbiology

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“…Approximately 300 cases of HCPS are reported each year in North and South America . SNV, which infects deer mouse, is the major cause of HCPS in North America (Fabbri and Maslow, 2001).…”

Section: A Epidemiologymentioning

confidence: 99%

Recent Advances in Hantavirus Molecular Biology and Disease

Hussein

Haseeb

Haque

et al. 2011

Advances in Applied Microbiology

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“…Hantaviruses are broadly classified into New World or Old World based on geographic location. Pathogenic New World hantaviruses cause a hantavirus cardiopulmonary syndrome (HCPS) in the Americas, whereas pathogenic Old World hantaviruses cause a hemorrhagic fever with renal syndrome (HFRS) in Europe and Asia (4,17,29,41,58). Andes virus (ANDV) and Sin Nombre virus (SNV) cause HCPS and are the most pathogenic hantavirus species found in South and North America, respectively, with a case fatality rate between 20 to 40% (32).…”

mentioning

confidence: 99%

Antagonism of Type I Interferon Responses by New World Hantaviruses

Levine¹,

Prescott

Brown

et al. 2010

J Virol

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“…As only a small percentage of known rodent species has been examined for the presence of hantavirus genetic material, this number is likely to increase. In North America, hantaviruses are the cause of hantavirus pulmonary syndrome (HPS), a severe respiratory illness with a greater than 40% mortality rate (6,8,28,43,44). Since the 1993 identification of HPS in the United States (32), many new hantaviruses have been discovered throughout the New World.…”

mentioning

confidence: 99%

Analysis of Hantavirus Genetic Diversity in Argentina: S Segment-Derived Phylogeny

Bohlman¹,

Morzunov

Meissner³

et al. 2002

J Virol

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Nucleotide sequences were determined for the complete S genome segments of the six distinct hantavirus genotypes from Argentina and for two cell culture-isolated Andes virus strains from Chile. Phylogenetic analysis indicates that, although divergent from each other, all Argentinian hantavirus genotypes group together and form a novel phylogenetic clade with the Andes virus. The previously characterized South American hantaviruses Laguna Negra virus and Rio Mamore virus make up another clade that originates from the same ancestral node as the Argentinian/Chilean viruses. Within the clade of Argentinian/Chilean viruses, three subclades can be defined, although the branching order is somewhat obscure. These are made of (i) "Lechiguanas-like" virus genotypes, (ii) Maciel virus and Pergamino virus genotypes, and (iii) strains of the Andes virus. Two hantavirus genotypes from Brazil, Araraquara and Castello dos Sonhos, were found to group with Maciel virus and Andes virus, respectively. The nucleocapsid protein amino acid sequence variability among the members of the Argentinian/Chilean clade does not exceed 5.8%. It is especially low (3.5%) among oryzomyine species-associated virus genotypes, suggesting recent divergence from the common ancestor. Interestingly, the Maciel and Pergamino viruses fit well with the rest of the clade although their hosts are akodontine rodents. Taken together, these data suggest that under conditions in which potential hosts display a high level of genetic diversity and are sympatric, host switching may play a prominent role in establishing hantavirus genetic diversity. However, cospeciation still remains the dominant factor in the evolution of hantaviruses.Hantaviruses, members of the Bunyaviridae family, are enveloped, single-stranded, negative-sense RNA viruses (10). The virus genome consists of three segments, designated large (L), medium (M), and small (S), that are packed into helical nucleocapsids. These segments encode the RNA polymerase (20, 42), a glycoprotein precursor that is cotranslationally processed to yield two envelope glycoproteins (G1 and G2) and a nucleocapsid (N) protein, respectively (38, 42).Each hantavirus is typically predominantly associated with a specific rodent host indigenous to the geographic area from which the hantavirus was characterized (15,21,30,32,33), although there appear to be occasional occurrences of spillover infections in related rodent species (3,5,15,27,28,41). According to most studies, the rodent host appears to be an asymptomatic carrier with a persistent lifetime infection (21, 51). However, recent data indicate that North American SinNombre-like viruses cause some pathology within their reservoir hosts (25, 31). The genus Hantavirus includes approximately 30 distinct virus serotypes/genotypes (20, 38, 39). As only a small percentage of known rodent species has been examined for the presence of hantavirus genetic material, this number is likely to increase. In North America, hantaviruses are the cause of hantavirus pulmonary syndrome (HP...

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Hantavirus pulmonary syndrome in the United States

Cited by 15 publications

References 47 publications

Recent Advances in Hantavirus Molecular Biology and Disease

Recent Advances in Hantavirus Molecular Biology and Disease

Antagonism of Type I Interferon Responses by New World Hantaviruses

Analysis of Hantavirus Genetic Diversity in Argentina: S Segment-Derived Phylogeny

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