Hantavirus Reservoir Hosts Associated with Peridomestic Habitats in Argentina

Abstract

Five species of sigmodontine rodents have been identified in Argentina as the putative reservoirs of six circulating hantavirus genotypes. Two species of Oligoryzomys are associated with the genotypes causing hantavirus pulmonary syndrome, Oligoryzomys flavescens for Lechiguanas and O. longicaudatus for Andes and Oran genotypes. Reports of human cases of hantavirus pulmonary syndrome prompted rodent trapping (2,299 rodents of 32 species during 27,780 trap nights) at potential exposure sites in three disease-endemic areas. Antibody reactive to Sin Nombre virus was found in six species, including the known hantavirus reservoir species. Risk for peridomestic exposure to host species that carry recognized human pathogens was high in all three major disease-endemic areas.

Prevalence of infection with hantavirus in rodent populations of central Argentina

“…The identification of the Pergamino virus in A. azarae also agrees with previous studies (Calderón et al 1999, Padula et al 2000a). The detection of Pergamino virus in one individual of O. flavescens suggests that the virus was transmitted between A. azarae and O. flavescens, but it could had been an incidental infection which not resulted in persistent infection.…”

“…The rates of hantavirus seroprevalence found in A. azarae and O. flavescens in this study were almost three times higher than those recorded by Calderón et al (1999) in localities of Buenos Aires province where cases of HPS have been reported: 9.3, n = 291 versus 2.7%, n = 549 P < 0.0001 for A. azarae and 13.5, n = 37 versus 4.7%, n = 170 P < 0.05 for O. flavescens, for this study and Calderón's study, respectively, test of comparison of two percentages (Bailey 1981). Strong variations in seroprevalences are not only evident when comparing studies conducted by different authors, but also within habitats and times (Abbott et al 1999.…”

“…Strong variations in seroprevalences are not only evident when comparing studies conducted by different authors, but also within habitats and times (Abbott et al 1999. In Argentina and other areas of the Americas seroprevalence range between 3-14% (Calderón et al 1999, Cantoni et al 2001, Yahnke et al 2001. However, the difference in seroprevalence could also be attributed to the different type of antigen used to estimate seroprevalence in each study (Sin Nombre and AND antigens for Calderón et al's and our study, respectively), although Toro et al (1998) did not find differences in serologic results obtained with these two types of antigen.…”

“…Nowadays, the occurrence of cases is concentrated in three geographically isolated areas: North (Salta and Jujuy provinces), Center (Buenos Aires, Santa Fe and Entre Ríos provinces), and Southwest (Neuquén and Río Negro provinces). In an extensive study conducted in sites were HPS cases occurred, many sigmodontine species were found infected with hantavirus, with seroprevalences which varied between 1.5 and 10.2%, depending on the area and species (Calderón et al 1999, Cantoni et al 2001. López et al (1996López et al ( , 1997 described the virus associated to HPS cases in Argentina, Andes virus (AND), as a new type of hantavirus.…”

Mode of Infection of Hokkaido Virus (Genus Hantavirus) among Grey Red‐Backed Voles, Myodes rufocanus, in Hokkaido, Japan

“…The host-virus relationships related to HFRS are Apodemus agrarius-Hantaan virus (HTNV) (32), Rattus norvegicus-Seoul virus (SEOV) (10), Apodemus flavicollisDobrava virus (DOBV) (4), and Myodes glareolusPuumala virus (PUUV) (44,60). The host-virus relationships in HPS are Peromyscus maniculatus-Sin Nombre virus (SNV) (43), Peromyscus leucopus-New York virus (NYV) (53), Sigmondon hispidus-Black Creek Canal virus (BCCV) (50,51), Oryzomys palustris-Bayou virus (BAYV) (29,55), Oligoryzomys longicaudatus-ANDV (8), Oligoryzomys flavescensLechiguanas virus (LECV) (8), Oligoryzomys microtisRio Mamore virus (RMV) (6), and Calomys lauchaLaguna Negra virus (LNV) (21).…”