“…By comparing Tables 2 , 3 one can see that the genes GSK3β , BDNF , and SLC6A4 (serotonin transporter) seem to be involved bilaterally in poor and good response to lithium in different studies. Some of these studies showed no significant association with lithium response for the following gene variants: BDNF gene, G196A/Val66Met ( Masui et al, 2006 ; Michelon et al, 2006 ; Wang et al, 2014 ) and rs10835210, rs11030101, rs11030102, rs12273363, rs2030324, rs2049045, rs6265”, rs7103411, rs962369, and rs988748 ( Drago et al, 2010 ); SLC6A4 gene, s/s, s/l, and l/l ( Serretti et al, 2004 ; Masoliver et al, 2006 ; Michelon et al, 2006 ; Manchia et al, 2009 ); and GSK3β gene, rs3755557 (-1727A/T) ( Michelon et al, 2006 ; Numajiri et al, 2012 ; Iwahashi et al, 2014 ), rs334558 (-50T/C) ( Szczepankiewicz et al, 2006 ; Iwahashi et al, 2014 ), and rs11921360-A ( Mitjans et al, 2015 ). On the other hand, other studies did find an association of the following variants of GSK3β , BDNF , and SLC6A4 with lithium response in patients with BD: GSK3β gene, rs334558 (−50T/C) ( Adli et al, 2007 ; Benedetti et al, 2012 ; Numajiri et al, 2012 ; Lin et al, 2013 ; Mitjans et al, 2015 , 3), rs6438552 ( McCarthy et al, 2011 ), rs3755557 (-1727A/T) ( Iwahashi et al, 2014 ), rs1732170-rs1192136 ( Mitjans et al, 2015 ); BDNF gene, Val66Met rs6265 ( Rybakowski et al, 2005 ; Dmitrzak-Weglarz et al, 2008 ; Rybakowski et al, 2012 ; Wang et al, 2012 ; Wang et al, 2014 ) and rs988748 ( Dmitrzak-Weglarz et al, 2008 ); and SLC6A4 gene, l/l and s/s ( Serretti et al, 2001 ; Benedetti et al, 2012 ), s allele and 10 repeat allele of STin2 (STin2.10) ( Tharoor et al, 2013 ), and ins/del 44 pz ( Rybakowski et al, 2012 ).…”