Haplotype-based, case–control study of myosin phosphatase target subunit 1 (<i>PPP1R12A)</i> gene and hypertensive disorders of pregnancy

Kono, Ai; Sato, Kaori; Nakayama, Tomohiro; Shikata, Elisa; Yamamoto, Tatsuo; Kawana, Kei

doi:10.1080/10641955.2021.1872613

Cited by 2 publications

(2 citation statements)

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“…In our past study, we reported the associations between HDPs and single-nucleotide variants (SNVs) or haplotypes in the human stromal interaction molecule 1 ( STIM1 ) gene that regulates the concentration of Ca 2+ and vascular contraction [ 6 ]. Furthermore, in a haplotype-based case-control study of the PPP1R12A gene, a significant difference was found between the control group and the HDP group [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study of the APELA Gene and Hypertensive Disorders of Pregnancy

et al. 2022

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Hypertensive disorders of pregnancy (HDPs) are believed to comprise a group of multifactorial genetic diseases. Recently, it was reported that APELA-knockout mice exhibited HDP-like symptoms, including proteinuria and elevated blood pressure due to defective placental angiogenesis. The aim of the present study is to determine the associations between HDPs and single-nucleotide variants or haplotypes in the human APELA gene through a case-control study. The subjects were 196 pregnant women with HDPs and a control group of 254 women without HDPs. Six single-nucleotide variants (rs2068792, rs13120303, rs4541465, rs13152225, rs78639146, and rs67448487) were selected from the APELA gene region. Although there were no significant differences for each single-nucleotide polymorphism in the case-control study, the frequency of the T-A haplotypes rs4541465–rs67448487 was significantly higher in the HDP group, especially in those with gestational hypertension, than in the control group. The results suggest that the APELA gene may be a disease-susceptibility gene for HDP.

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Section: Introductionmentioning

confidence: 99%

A Case-Control Study of the APELA Gene and Hypertensive Disorders of Pregnancy

et al. 2022

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“…In pregnancy hypertension, MYPT1-isoform switching is an adaptive response that reduces vascular resistance and maintains uterine blood flow [ 97 ]. Recently, a haplotype-base-control study, using a single nucleotide polymorphism between normal pregnant women and hypertensive disorders pregnant (HDP) women, showed that the disclosure polymorphism of the MYPT1 gene is an HDP disease-susceptibility gene [ 98 ]. These research reveal that the Ca 2+ sensitivity signaling pathway through RhoA/ROCK/MYPT1 contributes to pregnancy hypertension.…”

Section: Ca 2+ Sensitization In Hypertensionmentioning

confidence: 99%

Characterization of Contractile Machinery of Vascular Smooth Muscles in Hypertension

Yang

Hori

2021

Life

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Hypertension is a key risk factor for cardiovascular disease and it is a growing public health problem worldwide. The pathophysiological mechanisms of vascular smooth muscle (VSM) contraction contribute to the development of hypertension. Calcium (Ca2+)-dependent and -independent signaling mechanisms regulate the balance of the myosin light chain kinase and myosin light chain phosphatase to induce myosin phosphorylation, which activates VSM contraction to control blood pressure (BP). Here, we discuss the mechanism of the contractile machinery in VSM, especially RhoA/Rho kinase and PKC/CPI-17 of Ca2+ sensitization pathway in hypertension. The two signaling pathways affect BP in physiological and pathophysiological conditions and are highlighted in pulmonary, pregnancy, and salt-sensitive hypertension.

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Haplotype-based, case–control study of myosin phosphatase target subunit 1 (PPP1R12A) gene and hypertensive disorders of pregnancy

Cited by 2 publications

References 32 publications

A Case-Control Study of the APELA Gene and Hypertensive Disorders of Pregnancy

A Case-Control Study of the APELA Gene and Hypertensive Disorders of Pregnancy

Characterization of Contractile Machinery of Vascular Smooth Muscles in Hypertension

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