Haplotypes of the angiotensin-converting enzyme (ACE) gene are associated with coronary artery disease but not with restenosis after coronary stenting

Martínez-Ríos, Marco Antonio; Álvarez-León, Edith; Totomoch, Armando; Angeles, Javier; Peña‐Duque, Marco Antonio; Delgadillo-Rodríguez, Hilda; Martínez‐Rodríguez, Nancy; Ramírez-Fuentes, Silvestre; Fragoso, José Manuel; Vargas‐Alarcón, Gilberto

doi:10.1016/j.yexmp.2014.06.009

Cited by 11 publications

(8 citation statements)

References 20 publications

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“…The associations between restenosis risk and the analysed polymorphisms were analysed using the following genetic models: dominant, recessive and log-additive for PDGFB , EGF , TGFB1 and VEGF-A and dominant only for bFGF due to the low number of minor homozygotes. Similar to the methodology used by us [ 25 ] and others [ 27 , 28 ], these models were used for patients (n = 265) and adjusted for clinical variables that reached a p-value of <0.3 when comparing patients with and without significant ISR ( Table 2 ). Additionally, following the correction of angiographic data that reached p<0.3 in the group comparison ( Table 3 ), the effect of the considered polymorphisms on LLL (a continuous variable) was analysed.…”

Section: Methodsmentioning

confidence: 99%

The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent

et al. 2016

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BackgroundNeointima forming after stent implantation consists of vascular smooth muscle cells (VSMCs) in 90%. Growth factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A play an important role in VSMC proliferation and migration to the tunica intima after arterial wall injury. The aim of this paper was an analysis of functional polymorphisms in genes encoding TGF-β1, PDGFB, EGF, bFGF and VEGF-A in relation to in-stent restenosis (ISR).Materials and Methods265 patients with a stable coronary artery disease (SCAD) hospitalized in our center in the years 2007–2011 were included in the study. All patients underwent stent implantation at admission to the hospital and had another coronary angiography performed due to recurrence of the ailments or a positive result of the test assessing the coronary flow reserve. Angiographically significant ISR was defined as stenosis >50% in the stented coronary artery segment. The patients were divided into two groups–with angiographically significant ISR (n = 53) and without significant ISR (n = 212). Additionally, the assessment of late lumen loss (LLL) in vessel was performed. EGF rs4444903 polymorphism was genotyped using the PCR-RFLP method whilst rs1800470 (TGFB1), rs2285094 (PDGFB) rs308395 (bFGF) and rs699947 (VEGF-A) were determined using the TaqMan method.ResultsAngiographically significant ISR was significantly less frequently observed in the group of patients with the A/A genotype of rs1800470 polymorphism (TGFB1) versus patients with A/G and G/G genotypes. In the multivariable analysis, LLL was significantly lower in patients with the A/A genotype of rs1800470 (TGFB1) versus those with the A/G and G/G genotypes and higher in patients with the A/A genotype of the VEGF-A polymorphism versus the A/C and C/C genotypes. The C/C genotype of rs2285094 (PDGFB) was associated with greater LLL compared to C/T heterozygotes and T/T homozygotes.ConclusionsThe polymorphisms rs1800470, rs2285094 and rs6999447 of the TGFB1, PDGFB and VEGF-A genes, respectively, are associated with LLL in patients with SCAD treated by PCI with a metal stent implantation.

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Section: Methodsmentioning

confidence: 99%

The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent

et al. 2016

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“…Haplotypes will be examined based on single-nucleotide polymorphisms using the TaqMan 5' exonuclease genotyping assay. 32 However, because significant progress may be achieved in the field of genetic analysis in the coming years, the technologies existing at the time of analysis will be taken into consideration. Currently, the study of gene haplotypes of the renin–angiotensin–aldosterone system and the autonomic nervous system is considered.…”

Section: Methods and Analysismentioning

confidence: 99%

Protocol for a prospective longitudinal study of risk factors for hypertension incidence in a Mexico City population: the Tlalpan 2020 cohort

et al. 2017

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IntroductionSystemic hypertension (HTN) is a common risk factor for cardiovascular disease. In Mexico, HTN prevalence has increased over time and is currently 31%. Nonetheless, information about the country's HTN incidence and its associated risk factors is scarce. Understanding this condition is a priority for identifying the scope of primary prevention. The main objective of this study is to evaluate the effect of traditional and non-traditional risk factors on the incidence of HTN in a cohort of healthy Mexico City residents under biannual follow-up for 10 years.Methods and analysisA prospective longitudinal study is proposed in which clinically healthy residents of Mexico City between 20 and 50 years old will be recruited; the participants will be evaluated every 2 years over a period of 10 years or until they develop HTN. Evaluations regarding sociodemographic, clinical, anthropometric, biochemical, diet, physical activity, stress, sleep quality, alcohol and tobacco consumption factors will be performed. The participants will be recruited from the 16 municipalities of Mexico City through promotional strategies aimed at the community and will be clinically evaluated at a tertiary care institution, Instituto Nacional de Cardiología Ignacio Chávez (National Institute of Cardiology Ignacio Chavez), located in Mexico City, Mexico. Sample size estimated for this study is 3436, and the Cox proportional hazards model will be used to estimate HRs for the association between explanatory variables and HTN using both raw and adjusted data.Ethics and disseminationThis study was approved by the Institutional Bioethics Committee of the Instituto Nacional de Cardiología Ignacio Chávez (National Institute of Cardiology Ignacio Chavez) under number 13-802. Findings from this study will be disseminated through scientific papers and research conferences.

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“…The Chi-square test was used for determination of consistency with the Hardy-Weinberg equilibrium (HWE). Clinical variables were analyzed separately from angiographic variables (265 patients and 322 lesions, respectively), according to the methodology used by other authors [10,11]. As the number of minor homozygotes for each of the studied polymorphisms was relatively low, the analysis of risk of ISR depending on the analyzed polymorphisms was performed based on the dominant model (major homozygotes vs heterozygotes and minor homozygotes).…”

Section: Discussionmentioning

confidence: 99%

Functional Polymorphism Rs710218 in the Gene Coding GLUT1 Protein is Associated With In-Stent Restenosis

et al. 2015

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Haplotypes of the angiotensin-converting enzyme (ACE) gene are associated with coronary artery disease but not with restenosis after coronary stenting

Cited by 11 publications

References 20 publications

The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent

The Relationships between Polymorphisms in Genes Encoding the Growth Factors TGF-β1, PDGFB, EGF, bFGF and VEGF-A and the Restenosis Process in Patients with Stable Coronary Artery Disease Treated with Bare Metal Stent

Protocol for a prospective longitudinal study of risk factors for hypertension incidence in a Mexico City population: the Tlalpan 2020 cohort

Functional Polymorphism Rs710218 in the Gene Coding GLUT1 Protein is Associated With In-Stent Restenosis

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