Haplotypes of the IL-1 gene cluster are associated with gastroesophageal reflux disease and Barrett’s esophagus

Hollá, Lýdie Izakovičová; Linhartová, Petra Bořilová; Hrdličková, Barbara; Marek, Filip; Dolina, Jiří; Řihák, Vladimír; Kala, Zdeněk

doi:10.1016/j.humimm.2013.06.026

Cited by 15 publications

(12 citation statements)

References 38 publications

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“…Two interleukin variants also appear plausible: rs3212227 ( IL12B ) and rs917997 ( IL18RAP ) [ 23 – 25 ], with the former demonstrated to be independent of all other tested genotypes [ 26 ]. A number of other associations were reported in the IL1 [ 27 , 28 ], IL10 [ 28 ], IL18 [ 29 ], and IL23 [ 30 ] clusters. Of these, however, only wild-type rs917997 ( IL18RAP ) persisted following correction for multiple comparisons [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Genetic Biomarkers of Barrett’s Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis

2015

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Barrett’s esophagus (BE) is a common and important precursor lesion of esophageal adenocarcinoma (EAC). A third of patients with BE are asymptomatic, and our ability to predict the risk of progression of metaplasia to dysplasia and EAC (and therefore guide management) is limited. There is an urgent need for clinically useful biomarkers of susceptibility to both BE and risk of subsequent progression. This study aims to systematically identify, review, and meta-analyze genetic biomarkers reported to predict both. A systematic review of the PubMed and EMBASE databases was performed in May 2014. Study and evidence quality were appraised using the revised American Society of Clinical Oncology guidelines, and modified Recommendations for Tumor Marker Scores. Meta-analysis was performed for all markers assessed by more than one study. A total of 251 full-text articles were reviewed; 52 were included. A total of 33 germline markers of susceptibility were identified (level of evidence II–III); 17 were included. Five somatic markers of progression were identified; meta-analysis demonstrated significant associations for chromosomal instability (level of evidence II). One somatic marker of progression/relapse following photodynamic therapy was identified. However, a number of failings of methodology and reporting were identified. This is the first systematic review and meta-analysis to evaluate genetic biomarkers of BE susceptibility and risk of progression. While a number of limitations of study quality temper the utility of those markers identified, some—in particular, those identified by genome-wide association studies, and chromosomal instability for progression—appear plausible, although robust validation is required.Electronic supplementary materialThe online version of this article (doi:10.1007/s10620-015-3884-5) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Genetic Biomarkers of Barrett’s Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis

2015

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“…However, Muramatsu et al [24] found that the frequency of IL-1B-511 T alleles was significantly higher in GERD. In addition, Lzakovicova et al [23] claimed T allele of IL-1B-511 was not associated with GERD. The relationship between IL-1B-511 polymorphism and risk of GERD remains uncertain, and it was a challenge for a small sample-size study to explore such associations because of low statistical power.…”

Section: Discussionmentioning

confidence: 99%

Association of interleukin-1B gene polymorphisms at site 511 with gastroesophageal reflux disease: a meta-analysis

Xue

Zhang

et al. 2015

Esophagus

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“…The variable number of tandem repeat (VNTR) PCR technique was used for the detection of 86‐bp repetitions in the intron 2 of the IL‐1RN gene . These methods were optimized, and details were presented in our previous study …”

Section: Methodsmentioning

confidence: 99%

“…28 These methods were optimized, and details were presented in our previous study. 29 Single nucleotide analysis of the IL-6 gene (-597G>A rs1800797, -572G>C rs1800796, -174G>C rs1800795) was also based on the PCR-RFLP approach. 13,30 Amplification of DNA fragment containing polymorphism IL-6R (+48892A>C rs2228145) was carried out in reaction volume of 25.0 lL containing 75 ng of genomic DNA, 0.24 lmol/L of each primer, 15…”

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confidence: 99%

Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

Hollá

Valová

Linhartová

et al. 2017

J Oral Pathology Medicine

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Haplotypes of the IL-1 gene cluster are associated with gastroesophageal reflux disease and Barrett’s esophagus

Cited by 15 publications

References 38 publications

Genetic Biomarkers of Barrett’s Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis

Genetic Biomarkers of Barrett’s Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis

Association of interleukin-1B gene polymorphisms at site 511 with gastroesophageal reflux disease: a meta-analysis

Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

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